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[PDF] Top 20 HER2 as a novel therapeutic target for cervical cancer

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HER2 as a novel therapeutic target for cervical cancer

HER2 as a novel therapeutic target for cervical cancer

... personalized cancer treatment [5]. Although a heterotopic cervical cancer PDX models are useful for preclinical evaluation of personalized medicine, they are still limitations in translational ... See full document

12

Sphingosine kinase 1 is a reliable prognostic factor and a novel therapeutic target for uterine cervical cancer

Sphingosine kinase 1 is a reliable prognostic factor and a novel therapeutic target for uterine cervical cancer

... SPHK2 has antiproliferative effects. In contrast to the prosurvival factor SPHK1, overexpression of SPHK2 causes suppression of cell growth and cell cycle arrest [31]. Thus, SPHK1 and SPHK2 are not equivalent in their ... See full document

11

Fatty acid synthase phosphorylation: a novel therapeutic target in HER2 overexpressing breast cancer cells

Fatty acid synthase phosphorylation: a novel therapeutic target in HER2 overexpressing breast cancer cells

... that HER2-mediated FASN phosphorylation plays an important role in breast cancer progression and may be a novel therapeutic tar- get in HER2-overexpressing breast cancer ...and ... See full document

15

Mapping genetic vulnerabilities reveals BTK as a novel therapeutic target in oesophageal cancer

Mapping genetic vulnerabilities reveals BTK as a novel therapeutic target in oesophageal cancer

... Figure 5 Ibrutinib sensitivity in MYC and/or HER2 amplified oesophageal tumour cell lines. (A) Box plot depicting area under the curve values for ibrutinib. Preferential sensitivity to ibrutinib is observed in ... See full document

14

S100A10 in Cancer Progression and Chemotherapy Resistance: A Novel Therapeutic Target against Ovarian Cancer

S100A10 in Cancer Progression and Chemotherapy Resistance: A Novel Therapeutic Target against Ovarian Cancer

... in cancer cells leads to increased levels of plasmin which promote degradation of the extracellular matrix, increased angiogenesis and invasion of the surrounding ...in cancer cells including ovarian ... See full document

11

Original Article MiR-29a regulated FOXO3 expression and promoted the cell proliferation of human cervical cancer

Original Article MiR-29a regulated FOXO3 expression and promoted the cell proliferation of human cervical cancer

... Objective: Cervical cancer is one of the most common cancers and a leading cause of cancer-related mortality in women ...cervical cancer. Materials and methods: The expression of ... See full document

10

NITRIC OXIDE: A NOVEL THERAPEUTIC TARGET

NITRIC OXIDE: A NOVEL THERAPEUTIC TARGET

... superoxide (O2 - ) by diffusing and concentrating into the hydrophobic core of low-density lipoprotein (LDL). NO is involved in a variety of signaling mechanism which results in the alteration of proteins. NO has been ... See full document

13

The polycomb group protein EZH2 is a novel therapeutic target in tongue cancer

The polycomb group protein EZH2 is a novel therapeutic target in tongue cancer

... A total number of 84 patients with primary TSCC (2001 Jan.-2010 Dec.) receiving surgical treatment at the Department of oral and maxillofacial surgery, Nanjing Medical University were enrolled. Patient inclusion criteria ... See full document

18

Cripto-1 as a novel therapeutic target for triple negative breast cancer

Cripto-1 as a novel therapeutic target for triple negative breast cancer

... In this study, we extensively characterized a clinically relevant mouse model, which phenotypically and at the gene-expression level resembles the human TNBC molecular subtype. In this model, we used the JygMC(A) cell ... See full document

20

ER-α36: a novel biomarker and potential therapeutic target in breast cancer

ER-α36: a novel biomarker and potential therapeutic target in breast cancer

... and therapeutic response of breast ...a novel biomarker of great value for diagnosis, prog- nosis, and treatment of breast ...potential therapeutic target for breast cancer patients, ... See full document

9

ATP synthase ecto α subunit: a novel therapeutic target for breast cancer

ATP synthase ecto α subunit: a novel therapeutic target for breast cancer

... breast cancer cell lines, one with high and the other with low metastatic potential, was analyzed using two-dimensional liquid phase chromatographic fractionation (Proteome Lab PF 2D system) followed by ... See full document

15

MAP4K4: an emerging therapeutic target in cancer

MAP4K4: an emerging therapeutic target in cancer

... in cancer and MAP4K4 may represent a novel actionable cancer therapeutic ...in cancer, which could ultimately provide biological and mechanistic justifications for preclinical and ... See full document

9

A novel vaccine for cervical cancer: quadrivalent human papillomavirus (types 6, 11, 16 and 18) recombinant vaccine (Gardasil<sup>®</sup>)

A novel vaccine for cervical cancer: quadrivalent human papillomavirus (types 6, 11, 16 and 18) recombinant vaccine (Gardasil<sup>&reg;</sup>)

... the therapeutic benefi t of the low-risk HPV types vaccines that have been included in ...positive therapeutic effect, a strong cytotoxic T-cell (CTL) response should be ...of cervical cancer ... See full document

6

Original Article miR-98 suppresses tumor cell growth and metastasis by targeting IGF1R in oral squamous cell carcinoma

Original Article miR-98 suppresses tumor cell growth and metastasis by targeting IGF1R in oral squamous cell carcinoma

... potential target of miR-98 using dual luciferase assay, qRT-PCR and western ...inhibits cancer cell growth and metastasis by direct targeting IGF1R, implicating miR-98 as a novel potential ... See full document

8

&lt;p&gt;ER&amp;alpha;36 as a Potential Therapeutic Target for Tamoxifen-Resistant Breast Cancer Cell Line Through EGFR/ERK Signaling Pathway&lt;/p&gt;

<p>ER&alpha;36 as a Potential Therapeutic Target for Tamoxifen-Resistant Breast Cancer Cell Line Through EGFR/ERK Signaling Pathway</p>

... Acquired resistance to tamoxifen is clearly a complex phe- nomenon involving multiple pathways, and the exact molecu- lar mechanism of ER α 36 in regulating acquired tamoxifen resistance has not been elucidated until ... See full document

11

BIOMARKERS FOR THERAPEUTIC RESPONSE IN CERVICAL CANCER

BIOMARKERS FOR THERAPEUTIC RESPONSE IN CERVICAL CANCER

... mammalian target of rapamycin (mTOR) also known as FK506 binding protein 12- rapamycin associated protein 1 (FRAP1) is a protein which in humans is encoded by the FRAP1 ...of cervical cancer patients ... See full document

9

miR-129 as a novel therapeutic target and biomarker in gastrointestinal cancer

miR-129 as a novel therapeutic target and biomarker in gastrointestinal cancer

... There has been growing interest in the potential of miRNAs as cancer biomarkers. Identification of biomarkers has been a significant challenge, and those that are used, such as carci- noembryonic antigen for colon ... See full document

5

Novel approaches to target HER2-positive breast cancer: trastuzumab emtansine

Novel approaches to target HER2-positive breast cancer: trastuzumab emtansine

... of HER2-positive breast cancer is changing ...the target has not changed, our under- standing of the tumor biology and signaling pathways in HER2-positive tumors has increased ...targeting ... See full document

9

NFATC2 is a novel therapeutic target for colorectal cancer stem cells

NFATC2 is a novel therapeutic target for colorectal cancer stem cells

... the target genes of Hippo/YAP signaling pathway in CRC cells (Figure S3C and ...effective therapeutic strategy for human CRC caused by aberrant activation of ... See full document

14

&lt;p&gt;miR-451: A Novel Biomarker and Potential Therapeutic Target for Cancer&lt;/p&gt;

<p>miR-451: A Novel Biomarker and Potential Therapeutic Target for Cancer</p>

... a modest blood-based biomarker for papillary thyroid carcinoma malignancies and LN metastasis. Solomides et al 82 found that miR-451 levels could be used as a biomarker to distinguish normal lung tissues from malignant ... See full document

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