[PDF] Top 20 Herpes Simplex Virus 1 Suppresses the Function of Lung Dendritic Cells via Caveolin-1
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Herpes Simplex Virus 1 Suppresses the Function of Lung Dendritic Cells via Caveolin-1
... for virus- induced pneumonia (4, 43). In agreement with evidence that Cav-1 might facilitate virus replication (29), we observed that the expression of Cav-1 significantly elevated ... See full document
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Herpes Simplex Virus Type 1 Induces CD83 Degradation in Mature Dendritic Cells with Immediate-Early Kinetics via the Cellular Proteasome
... DC function by modulating the CD83 molecule has been reported ...At 1 day postinfection, HCMV-infected mDCs show only very low surface expression of CD83 but the molecule is still expressed intracellularly ... See full document
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Herpes Simplex Virus Type 1 (HSV-1)-Induced Apoptosis in Human Dendritic Cells as a Result of Downregulation of Cellular FLICE-Inhibitory Protein and Reduced Expression of HSV-1 Antiapoptotic Latency-Associated Transcript Sequences
... wild-type virus (strain ...mutant virus were not dif- ferent ...antiapoptotic function of LAT ...mutant virus was due to altered expression of viral lytic genes in iDCs, thus inducing more ... See full document
13
Dendritic Cells Are Required for Optimal Activation of Natural Killer Functions following Primary Infection with Herpes Simplex Virus Type 1
... NK cells, limited to the popliteal lymph nodes (PLN) of mice, had the ability to produce IFN- ␥ and that the absence of DCs led to a marked decrease in IFN- ␥ production by NK ...NK cells in innate ... See full document
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Immature Monocyte-Derived Dendritic Cells Are Productively Infected with Herpes Simplex Virus Type 1
... infected cells. Thus, it is possible that infected DC may continue to function for the first and critical 24 to 48 h after ...UV-inactivated virus did not affect the normal progressive upregulation ... See full document
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Role of Dendritic Cells in Enhancement of Herpes Simplex Virus Type 1 Latency and Reactivation in Vaccinated Mice
... from virus replication in the eye or the establishment of latency in the TGs (47, 52), suggesting that protection against virus replication in the eye and the establishment of latency is harder to ... See full document
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Effective Priming of Herpes Simplex Virus-Specific CD8+ T Cells In Vivo Does Not Require Infected Dendritic Cells
... “second” antigenic hit to HSV-specific CD8 ⫹ T cells initially primed by CD8 ⫹ DC as they egress from the LN. This could be relevant for migrational imprinting, consolidation of effector function, and/or ... See full document
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Imiquimod Suppresses Propagation of Herpes Simplex Virus 1 by Upregulation of Cystatin A via the Adenosine Receptor A1 Pathway
... [R837; 1-(2-methylpropyl)-1H-imidazo[4,5-c]quino- lin-4-amine] and resiquimod [R848; 4-amino-2-(ethoxymethyl)- ␣ , ␣ -dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol], which are immune response modifiers of ... See full document
9
Mature Dendritic Cells Infected with Herpes Simplex Virus Type 1 Exhibit Inhibited T-Cell Stimulatory Capacity
... Here we report that HSV-1-infected mature DC are inhib- ited in their T-cell-stimulatory capacity. Furthermore, we show that mature DC do not generate infectious virus particles. On the transcriptional ... See full document
10
Herpes Simplex Virus Type 1 Suppresses RNA-Induced Gene Silencing in Mammalian Cells
... or virus to silence virus gene expression and the ability of the virus to suppress ...silenced cells, maximum levels of EGFP mRNA were observed 8 to 10 h following HSV-1 infection but ... See full document
12
Herpes Simplex Virus 1 UL41 Protein Suppresses the IRE1/XBP1 Signal Pathway of the Unfolded Protein Response via Its RNase Activity
... in dendritic cells (43). IRE1 could cleave viral mRNA via its endoribonuclease activity into single-stranded fragments that lack markers of self, activating the retinoic acid-inducible gene I (RIG-I) ... See full document
8
Herpes Simplex Virus 1 ICP22 Suppresses CD80 Expression by Murine Dendritic Cells
... 293 cells and Gene Porter 2 (Genlantis, San Diego, CA). Briefly, cells were grown to 70% to 80% confluence in 12-well ...The cells were transfected with either promoterless luciferase plasmid ... See full document
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Dendritic Cell Autophagy Contributes to Herpes Simplex Virus Driven Stromal Keratitis and Immunopathology
... the virus and downstream ...T cells (32). This difference could simply result from different virus and mouse strains used in this study ...T cells, which is dependent on both the type of ... See full document
12
Human Dendritic Cells Transduced with Herpes Simplex Virus Amplicons Encoding Human Immunodeficiency Virus Type 1 (HIV-1) gp120 Elicit Adaptive Immune Responses from Human Cells Engrafted into NOD/SCID Mice and Confer Partial Protection against HIV-1 Challenge
... The virus also infects mucosal surfaces and has the ability to establish latent infection in the host, which is characterized by the prolonged expression of a small subset of viral ...immunostimulatory ... See full document
9
Activation of NF-κB in CD8+ Dendritic Cells Ex Vivo by the γ134.5 Null Mutant Correlates with Immunity against Herpes Simplex Virus 1
... mutant-induced NF- B activation in DCs might be a determinant of protective immunity. To test this hypothesis, we carried out the NF- B inhibition-coupled adoptive transfer assays. Immature CD11c ⫹ DCs were infected ... See full document
10
Amplification of Reiterated Sequences of Herpes Simplex Virus Type 1 (HSV 1) Genome To Discriminate between Clinical HSV 1 Isolates
... detected only three different alleles among 37 unrelated clin- ical HSV-1 isolates, which is not surprising since ReVII is located within a protein-coding region, making it a target for selective pressure. More ... See full document
6
Diagnosis of HSV Encephalitis in suspected Infants by using Real Time PCR at Gauhati Medical College and Hospital, Gauhati
... a virus or foreign protein. Herpes Simplex Virus-1 is one of the major causes of ...the virus at delivery can produce severe disseminated infection and ...India herpes ... See full document
5
A Gene Capable of Blocking Apoptosis Can Substitute for the Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene and Restore Wild-Type Reactivation Levels
... One unexpected result in these studies was that CJLAT caused severe corneal scarring in most of the infected rabbits. The corneal scarring was not apparent until after day 30 p.i., a time well after all primary infection ... See full document
12
Regulation and Function of Phosphorylation on VP8, the Major Tegument Protein of Bovine Herpesvirus 1
... transfected cells developed circular bodies in the nucleus, with WT-VP8 being strongly la- beled on these circular ...infected lung tissue (Fig. 6B). Some cells in the infected tissue developed ... See full document
14
Nerve growth factor inhibits TLR3-induced inflammatory cascades in human corneal epithelial cells
... immunity via TLRs, NGF could promote cell cycle progression of HCECs by regulating D-type cyclins via PI3K/Akt and MAPK/Erk activation [33, ...stem cells proliferation, colony- forming efficiency, ... See full document
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