[PDF] Top 20 HIF 1 and HIF 2: working alone or together in hypoxia?
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HIF 1 and HIF 2: working alone or together in hypoxia?
... the HIF tran- scriptional cascade is constitutively activat- ed (4, ...of HIF-1α expres- sion in nonneoplastic renal tubules (5) is altered strikingly in favor of HIF-2α expres- ...of HIF-2α ... See full document
5
Hypoxia inducible factor–2 (HIF 2) regulates hepatic erythropoietin in vivo
... of HIF-2 in the regulation of EPO expression does not appear to be restricted to ...germline-transmitted Hif-2α knockout or hypomorph alleles have suggested that renal Epo as well as retinal Epo ... See full document
11
Hypoxia promotes fibrogenesis in vivo via HIF 1 stimulation of epithelial to mesenchymal transition
... epithelial Hif-1α is fibrogenic in a chronic renal injury model and thus exerts a disease-promoting ...that HIF-1 may have a context- and/or cell type–specific biological role with regard to renal ... See full document
12
Regulation of obesity and insulin resistance by hypoxia-inducible factors
... O 2 ) or hypoxia mimetic CoCl 2 treatment significantly reduced phosphorylation of insulin receptor (IR) and protein kinase B in 3T3-L1 and differentiated human ...of HIF-1 α or ... See full document
13
Expression of HIF 1α and HIF 2α correlates to biological and clinical significance in papillary thyroid carcinoma
... between HIF-1 α and HIF-2 α in PTCs. High expression of HIF-1 α and HIF-2 α was associated with high TNM stage and ...targeting hypoxia-associated and ... See full document
7
HIF-1 and TAZ serve as reciprocal co-activators in human breast cancer cells
... that HIF-1, but not HIF- 2, binds directly to the WWTR1 gene encoding the transcriptional co-activator with PDZ-binding motif (TAZ), an effector of Hippo signaling ...expression, HIF- ... See full document
11
ZMYND8 acetylation mediates HIF dependent breast cancer progression and metastasis
... O 2 availability (hypoxia) with median partial pressure of oxygen (PO 2 ) values of 10 mmHg, which is markedly lower than 65 mmHg in normal breast tissues ...moral hypoxia to drive breast ... See full document
20
Development of Inhibitors Targeting Hypoxia Inducible Factor 1 and 2 for Cancer Therapy
... of HIF inhibitors have been synthesized or discov- ered for treating cancer, particularly for advanced and refrac- tory solid ...of HIF-1α, or HIF-2α, or both, through direct and indirect mech- ... See full document
8
Expression of hypoxia inducible factor 1α and 2α and its association with vitamin C level in thyroid lesions
... of HIF-1α and HIF-2α proteins in thyroid lesions, however the studied groups characterized wide variations in both subunits ...of HIF proteins via a combination of tumor genotype and ...with ... See full document
10
Hypoxia-inducible factor-mediated induction of WISP-2 contributes to attenuated progression of breast cancer
... Abstract: Hypoxia and the hypoxia-inducible factor (HIF) signaling pathway trigger the expres- sion of several genes involved in cancer progression and resistance to ...active HIF-1 and ... See full document
11
Hypoxia The role of hypoxia and HIF dependent signalling events in rheumatoid arthritis
... Because hypoxia and HIF activation and angiogenesis are features of RA, it could be suggested that PHD enzymes are in some way downregulated in RA, and such conditional PHD knock- out mice could in the ... See full document
9
Low oxygen tension increases mitochondrial membrane potential and enhances expression of antioxidant genes and implantation protein of mouse blastocyst cultured in vitro
... factor, HIF), HIF targets (vascular endothelial growth factor, VEGF; glucose transporter 3, GLUT-3) and antioxidants (manganese superoxide dismutase, MnSOD; peroxiredoxin 5, PRDX5) were assessed using ... See full document
11
Effects of acute hypoxia exposure with different durations on activation of Nrf2-ARE pathway in mouse skeletal muscle
... After 20 μg total proteins from the muscle samples and 10 μg total proteins from C2C12 cell were separated on a Bolt Bis-Tris plus 4–12% gel (Life Technologies, USA) by electrophoresis, the fractionated proteins were ... See full document
15
Nonhypoxic regulation and role of hypoxia inducible factor 1 in aromatase inhibitor resistant breast cancer
... hypoxic HIF-1 α is inherently expressed in AI-resistant cells, upregulated by HER2-PI3K/Akt-mTOR pathway and is an important factor in letrozole-resistant breast cancer cells, regulating target genes such ... See full document
18
Emerging evidence of the physiological role of hypoxia in mammary development and lactation
... that hypoxia and HIF-1α can induce STAT5 phosphorylation and enhance its DNA-binding activity in mammary epithelial cells and breast cancer cells ...Thus, hypoxia may be involved in mammary ... See full document
11
Erythropoietin and the hypoxic brain
... of HIF-α, blocking interaction with transcriptional coactivators (Lando et ...factor-inhibiting HIF-1 (FIH-1; Hewitson et ...during hypoxia (Fig.·1). The lack of hydroxylation ... See full document
10
Hypoxia inducible factor 1α gene (HIF-1α) splice variants: potential prognostic biomarkers in breast cancer
... Differences among groups of breast tissue specimens (normal/benign tissues vs carcinomas) in terms of their HIF-1 a mRNA levels were assessed using Kruskal-Wallis and Mann-Whitney tests with Bonferroni ... See full document
11
Endothelial cell pseudopods and angiogenesis of breast cancer tumors
... of hypoxia inducible factor 1- α (HIF) reveals the subcortical area of the tumor to contain HIF positive cells while the tumor capsule, cortex and necrotic areas of the tumor demonstrate no ... See full document
5
Inhibitory effect of Samul tang on retinal neovascularization in oxygen induced retinopathy
... this hypoxia strongly stimulates pro-angiogenic factors and results in abnormal neovascularization [23, ...of HIF-1α, SDF-1, CXCR4 and VEGF in OIR ...on HIF pathway- mediated ... See full document
7
Epithelial HIF 1α/claudin 1 axis regulates barrier dysfunction in eosinophilic esophagitis
... claudins 1, 4, and 7 (33), no pre- vious assessment examined a larger panel of transmembrane junctional molecules in the healthy ...claudins 1, 4, and 7 to be the most highly expressed. Further- more, in ... See full document
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