[PDF] Top 20 High level of susceptibility to human TRIM5α conferred by HIV 2 capsid sequences
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High level of susceptibility to human TRIM5α conferred by HIV 2 capsid sequences
... which HIV-1 originates (Pan troglodytes troglodytes) is relatively closely related to humans [14], suggesting that little adaptation may have been needed on the part of HIV-1 to resist the anti- viral ... See full document
11
Human TRIM5α mediated restriction of different HIV 1 subtypes and Lv2 sensitive and insensitive HIV 2 variants
... including HIV-1 group O) for the characterization of human TRIM5α mediated restriction, the indicator cell line TZM-bl [20] was stably transduced with a retroviral vector (LNCX2, Clonetech, Germany) ... See full document
7
Strain-Specific Differences in the Impact of Human TRIM5α, Different TRIM5α Alleles, and the Inhibition of Capsid-Cyclophilin A Interactions on the Infectivity of HIV-1
... of human cells by IFN- ␣ increases the expression of TRIM5 ␣ (5, 10, ...the susceptibility of HIV-1 to human TRIM5 ␣ , we first examined the impact of IFN- ␣ on the infectivity of recombinant ... See full document
10
An integrated map of HIV genome wide variation from a population perspective
... genomic sequences from 1705 patients infected with 16 major HIV groups, subtypes and circulating recombinant forms (CRFs) were analyzed along with structural, immunological and peptide inhibitor ...of ... See full document
18
TRIM5α Resistance Escape Mutations in the Capsid Are Transferable between Simian Immunodeficiency Virus Strains
... studying HIV pathogenesis and evaluating HIV vaccine strat- ...the high diversity of circulating HIV-1 pri- mary strains, the most widely used SIV challenge strains are all derived from ... See full document
9
The Human TRIM5α Restriction Factor Mediates Accelerated Uncoating of the N-Tropic Murine Leukemia Virus Capsid
... the level of particulate HIV-1 capsids is observed in the cytosol of cells expressing a restricting TRIM5 ␣ protein ...N-MLV capsid pro- tein, p30, following exposure to viruses with and without en- ... See full document
11
Genetic Diversity and Recombination of Porcine Sapoviruses
... to high titer in the pig host (electron microscopy negative, RT-PCR weakly positive), nor did it spread efficiently in the herd, suggesting a possible alternative host origin, such as from humans, based on the ... See full document
10
Reduced Susceptibility of Human Immunodeficiency Virus Type 1 (HIV-1) from Patients with Primary HIV Infection to Nonnucleoside Reverse Transcriptase Inhibitors Is Associated with Variation at Novel Amino Acid Sites
... reduced susceptibility was apparent from the tree, but there are a small number of clusters with strong bootstrap ...reduced susceptibility. Although supported in 100% of bootstraps, these sequences ... See full document
5
Drug manufacturing and access to medicines: the West African story. A literature review of challenges and proposed remediation
... It is the right of all humans to have access to safe, quality and effective medicines. This article seeks to expound on the problems of drug manufacturing and challenges of accessing medicines in West Africa, and ... See full document
15
Heterologous protection elicited by candidate monomeric recombinant HIV 1 gp120 vaccine in the absence of cross neutralising antibodies in a macaque model
... SF33 HIV-1 envelope ...1, 2, 3 and 4 showed little homology between W61D, IIIB and SF33 sequences and were divided into 3 pools that approxi- mately covered V1/V2, V3 and V4 regions for each enve- ... See full document
14
HLA-associated polymorphisms in the HIV-2 capsid highlight key differences between HIV-1 and HIV-2 immune adaptation.
... acute HIV-2 infection to demonstrate CTL-driven escape, shown extensively in HIV-1 ...of HIV- 2 infection in West Africa, on a background of vastly lower transmission rates than ... See full document
7
A single amino acid substitution of the human immunodeficiency virus type 1 capsid protein affects viral sensitivity to TRIM5α
... with HIV-1 L4/5 (lanes 1 to 4, upper panel), but not in those with SIVmac L4/5 (lanes 5 to 7) indicating that the G-to-E substitution at the 116th amino acid position had no effect on CypA binding of HIV-1 ... See full document
10
The TRIM5α B-Box 2 Domain Promotes Cooperative Binding to the Retroviral Capsid by Mediating Higher-Order Self-Association
... B-box 2 domain of TRIM5 ␣ eliminate its antiretroviral activity (7, 9, 14, 30, ...retroviral capsid can still be recognized by these mutant TRIM5 ␣ proteins; however, because B-box 2 changes often ... See full document
8
Loss of Raltegravir Susceptibility by Human Immunodeficiency Virus Type 1 Is Conferred via Multiple Nonoverlapping Genetic Pathways
... of HIV-1, the development of resistance to RAL is associated with treatment failure, ...the susceptibility and IN-mediated replication capacity (RC) of patient viruses, which provide additional information ... See full document
7
High level of HIV 1 drug resistance among patients with HIV 1 and HIV 1/2 dual infections in Guinea Bissau
... In the context of ART rollout, the most important drug resistance mutations in HIV-1 were single amino-acid mutations that conferred high-level resistance to NNRTIs. This finding was not ... See full document
6
Innovative Algorithms and Evaluation Methods for Biological Motif Finding
... been HIV positive since the early 1980’s and indicated there were distinct differences between sexual risk factors among younger HIV positive MSM and those who had been living with the disease for a number ... See full document
203
Characterization of Human Endogenous Retroviral Elements in the Blood of HIV-1-Infected Individuals
... of HIV-1 and breast cancer patients. Plasma samples from one HIV-1 patient with a low HIV-1 RNA load (A) and another patient with a high HIV-1 RNA load (B) were fractionated by density ... See full document
15
Study of association of <em>PAX6</em> polymorphisms with susceptibility to high myopia in a Japanese population
... The aim of the present study was to assess whether polymor- phisms in the PAX6 gene region affect the development of high/extreme myopia in our Japanese population. Patients with SE,- 9.00 D in at least one eye ... See full document
7
The Interaction between the Major Capsid Protein and the Smallest Capsid Protein of Human Cytomegalovirus Is Dependent on Two Linear Sequences in the Smallest Capsid Protein
... smallest capsid proteins and the major capsid proteins of herpesviruses were initially described by Rixon and colleagues ...major capsid protein VP5 and the smallest capsid protein VP26 ... See full document
6
The Three-Fold Axis of the HIV-1 Capsid Lattice Is the Species-Specific Binding Interface for TRIM5α
... V181A capsid trimer. (a and b) Assemblies of HIV-1 capsid cysteine mutants that mimic the HIV-1 capsid surface and enable cross-linking of NTD-trimer ...V181A HIV-1 ...of ... See full document
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