[PDF] Top 20 HIV 1 integrase modulates the interaction of the HIV 1 cellular cofactor LEDGF/p75 with chromatin
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HIV 1 integrase modulates the interaction of the HIV 1 cellular cofactor LEDGF/p75 with chromatin
... to chromatin tethering assay This assay was previously described [13] and is based on the capacity of LEDGF/p75 to tether HIV-1 inte- grase to chromatin ...lack ... See full document
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Characterization of the HIV 1 integrase chromatin and LEDGF/p75 binding abilities by mutagenic analysis within the catalytic core domain of integrase
... the interaction with LEDGF/p75 but were still able to bind ...for LEDGF/p75 also failed to dissociate IN from ...a LEDGF/p75-independent determinant for host ... See full document
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Discovery of a novel 5-carbonyl-1H-imidazole-4-carboxamide class of inhibitors of the HIV-1 integrase–LEDGF/p75 interaction
... of HIV-1 integrase catalysis, clinical resistance mutations have limited the promise of long-term drug ...of integrase activity has emerged as a promising approach to antiretroviral discovery ... See full document
10
Transcriptional Coactivator LEDGF/p75 Modulates Human Immunodeficiency Virus Type 1 Integrase-Mediated Concerted Integration
... type 1 (HIV-1), murine leuke- mia virus (MLV), and avian sarcoma-leukemia virus in human chromosomes (25, 34, 36, 37, ...51). HIV-1 predominantly inte- grates within genes, having a ... See full document
11
LEDGF Dominant Interference Proteins Demonstrate Prenuclear Exposure of HIV-1 Integrase and Synergize with LEDGF Depletion To Destroy Viral Infectivity
... endogenous LEDGF and hence with PIC attachment to the chromatin ...of LEDGF in HIV-1 integration: tethering of the PIC to the chromosomal DNA target (LEDGF as a chromosome ... See full document
14
Transient and Stable Knockdown of the Integrase Cofactor LEDGF/p75 Reveals Its Role in the Replication Cycle of Human Immunodeficiency Virus
... the interaction between the transcriptional coactivator lens epithelium-derived growth factor (LEDGF/p75) and the human immunodeficiency virus type 1 (HIV-1) integrase ... See full document
11
Dual inhibition of HIV 1 replication by integrase LEDGF allosteric inhibitors is predominant at the post integration stage
... IN-LEDGF interaction, given the role of LEDGF in the tethering of IN to chromatin during the integration process of ...the LEDGF- binding pocket of ...the LEDGF-binding pocket of ... See full document
21
Changes in the accessibility of the HIV 1 Integrase C terminus in the presence of cellular proteins
... of HIV-1 integrase by a human homolog of yeast transcription factor ...R: Integrase Mutants Defective for Interaction with LEDGF/p75 Are Impaired in Chromosome Tethering ... See full document
10
Noncovalent SUMO interaction motifs in HIV integrase play important roles in SUMOylation, cofactor binding, and virus replication
... of HIV IN and investigated three putative SIMs of IN: SIM1 72VILV75, SIM2 200IVDI203 and SIM3 ...the interaction between IN and SUMO E2 conjugation enzyme ...with LEDGF/p75 but not with ...on ... See full document
14
Allosteric Integrase Inhibitors Reveal a Role for Integrase During HIV-1 Maturation
... that LEDGF/p75 can be incorporated into the HIV-1 particle through a direct interaction with the Gag-Pol polyprotein ...is LEDGF/p75-independent during the late stages of ... See full document
190
LEDGF/p75 Determines Cellular Trafficking of Diverse Lentiviral but Not Murine Oncoretroviral Integrase Proteins and Is a Component of Functional Lentiviral Preintegration Complexes
... type 1 (HIV-1), feline immunodeficiency virus (FIV), and Moloney murine leukemia virus (MoMLV) integrases were stably expressed to determine their intracellular ...lentiviral integrase ... See full document
14
Biochemical and Functional characterization of the LEDGF/p75-MeCP2 Interaction in Tumor Cells
... this interaction to the activation of stress survival ...Introduction LEDGF/p75 is a stress response protein with relevance to cancer, autoimmunity, inflammation, eye disease, and replication of the ... See full document
204
Identification and Characterization of PWWP Domain Residues Critical for LEDGF/p75 Chromatin Binding and Human Immunodeficiency Virus Type 1 Infectivity
... p75 interaction is understood, while the mechanism of chromatin binding is ...protein interaction modules that together comprise the Tudor ...the LEDGF/p75 PWWP domain were ... See full document
13
1,2,3,4-Tetrahydroisoquinolines as inhibitors of HIV-1 integrase and human LEDGF/p75 interaction
... the LEDGF/p75 binding site on IN ...hydrophobic interaction with one face of the hydrophobic pocket of CCD dimer comprised of residues Q95, T124, T125, A128, while the isoquinoline core of 6d has a ... See full document
12
HIV 1 IN/Pol recruits LEDGF/p75 into viral particles
... Furthermore, LEDGF/p75 has been identified as a Pol interaction ...whether LEDGF/p75 besides acting as a molecular tether in the target cell, also affects late steps of HIV ... See full document
15
Peptides derived from the HIV 1 integrase promote HIV 1 infection and multi integration of viral cDNA in LEDGF/p75 knockdown cells
... 31. Jenkins TM, Engelman A, Ghirlando R, Craigie R: A soluble active mutant of HIV-1 integrase: involvement of both the core and carboxyl-terminal domains in multimerization. J Biol Chem 1996, ... See full document
11
Integration of HIV-1 DNA Is Regulated by Interplay between Viral Rev and Cellular LEDGF/p75 Proteins
... once LEDGF/p75 is removed (see Fig- ure 1B, Figure ...of HIV-1 cDNA integration and of the involvement of LEDGF/p75 and Rev in regulating the integration events is presented in ... See full document
11
HRP 2 determines HIV 1 integration site selection in LEDGF/p75 depleted cells
... 4). HIV-1 integration in wild-type cells is generally disfavored near marks associated with tran- scriptionally silent regions and ...heterochromatin. LEDGF/p75 depletion shifts this phenotype ... See full document
7
Histone deacetylase 1 interacts with HIV 1 Integrase and modulates viral replication
... The identification and characterization of new IN cel- lular cofactors remains an important goal as it provides a more complete understanding of viral integration and can potentially lead to the development of new ... See full document
17
Integrase and integration: biochemical activities of HIV 1 integrase
... infection. Integrase, a retroviral enzyme, catalyses ...length integrase was reported, in vitro, by our group for two retroviral integrases (HIV-1 and PFV- ... See full document
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