[PDF] Top 20 Hormone-Sensitive Lipase Knockouts

... triacylglycerol lipase activity in WAT was reduced by only 40–50% and triacylglycerol lipase activity in BAT was similar to wild type mice [2,3,5], suggesting the existence of one or more other neutral ... See full document

... kinase hormone- sensitive lipase complex with dibutyryl ...of hormone- sensitive lipase was decreased by approximately 40% in ... See full document

... triglyceride lipase (ATGL) and perilipin, as well as phosphorylation of hormone-sensitive lipase (HSL), AMP-activated protein kinase (AMPK), and mitogen-activated protein kinases (MAPKs) were ... See full document

... The lipase inhibitory activity was assessed using different lipases: Pancreatic lipase (PL),Hormone sensitive lipase(HSL)[13],Monoacylglycerol ...microbial lipase inhibitor and ... See full document

... a lipase that is more efficient at low temperatures, as has commonly been reported for a variety of other enzymes (Somero, 1995), (2) elevated titers of the enzyme in tissues of Antarctic fish or (3) a reduced ... See full document

... six lipase genes listed in order of genetic association significance, as follows: LIPF gastric lipase, LIPC hepatic lipase, LIPG endothelial lipase, LIPE hormone-sensitive ... See full document

... Despite higher or identical mRNA levels in the lean and the obese subjects and in subcutaneous and omental tissues, perilipin protein expression was lower in both depots in the obese ver[r] ... See full document

... nonactivated hormone-sensitive lipase to its activated form, as indicated by a decrease in the activation subsequently obtainable in fractions prepared from such hormone-treated ...of ... See full document

... containing the insert (vector alone) where HSL expression was very low, undifferentiated HSL transfectants had up to a 100-fold increase in HSL activity. Likewise, immunoreactive HSL protein and HSL mRNA levels were ... See full document

... increase in phosphorylation w as not further increased by TZD treatm ent. The same treatm ent led to a reduction in basal HSL activity. These results could explain w hy experim ents carried out in anim al m odels show a ... See full document

... differentiation in rats [30, 31], our findings suggest that progesterone has a role in the regulation of fat mass. Despite evidence that HT (hormone therapy) does not cause weight gain, many women express concern ... See full document

... Among patients with secondary hyperparathyroidism and normal renal function, iPTH was 3- to 8-fold elevated in those with.. rickets, and 1.3- to 2.0-fold above normal in those with.[r] ... See full document

... This study is a retrospective study and, thus, has certain limitations, including a selection bias which might have influenced our results. Our observation period was differ- ent for patients who continued degarelix and ... See full document

... thyroid hormone regulates such a wide range of cellular pro- cesses in so many different ...same hormone stimulate the dif- ferentiation of an embryonic neuroblast but trigger an entirely different response ... See full document

... It is concluded that these subjects with low serum sodium and total solute concentration were sensitive to further changes in tonicity, and that the release of antidiuretic hormone was r[r] ... See full document

... Even minimal disease, such as a single positive pelvic lymph node LN, precluded a definitive therapy, and these patients were treated with androgen-deprivation therapy ADT.8 However, wit[r] ... See full document

... In 2019, trials emerged evaluating androgen receptor inhi- bitors in mHSPC, starting with enzalutamide, which is now used widely in the management of castration- resistant disease. The ARCHES trial evaluated 1150 men ... See full document

... Androgen ablation therapy using GnRH agonist is one of the techniques in achieving medical castration. Leuprolide and goserelin are commonly used GnRH. Its administration is usually staggered (for example, day 1-, 3-, ... See full document

... anti- lipase IgY has an anti-obesity ...pancreatic lipase inhibitor, Orlistat, has been used in clinics for the prevention of obesity [2], and Orlistat has been shown not only to pre- vent body weight gain ... See full document

... the efficacy of docetaxel in addition to ADT compared with ADT alone in patients with hormone-sensitive pros- tate cancer. All enrolled patients in the GETUG-AFU 15 and CHAARTED-E3805 trials had metastases. ... See full document