[PDF] Top 20 Human Cytomegalovirus Induces Multiple Means To Combat Reactive Oxygen Species

... Free radicals and other reactive oxygen species (ROS) are generated as by-products of many cellular processes, primarily mitochondrial respiration. ROS can be an important modula- tor of cellular ... See full document

... Active oxygen species played a key role in the induction of asbestos-induced apoptosis in mesothelial ...other means that reac- tive oxygen species mediated asbestos-induced apoptosis ... See full document

... Plasmids. The 4.8-kb HindIII N fragment from the HSV-1(F) genome (nu- cleotides 133466 to 138349, containing Us5) was cloned into pBluescript KS( ⫺ ) between the SacI and PstI sites. First, pBluescript KS( ⫺ ) was ... See full document

... propagate along the waveguide and also so that 35 mm Petri dishes could be accommodated within the waveguide. To produce the radiation, a 3 GHz function generator (E4431B; Agilent, Palo Alto, CA) was used to generate a ... See full document

... the human microbiome, residing within multiple body sites, including the skin, oral cavity, gastrointestinal tract, and ...possesses multiple virulence attributes, including filamentous growth, ... See full document

... the means±standard devi- ation. The means were compared to those of untreated control cells using Student ’ s ...Bonferroni multiple comparison post-hoc test was performed when more than two groups ... See full document

... reduce oxygen to superoxide on the leaflet facing the mitochondrial matrix, and contains a Q-binding site, a flavin mononucleotide, and multiple iron- sulfur clusters that directly participate in ROS ... See full document

... a means of introducing plasmids that encode antioxidant cDNAs into T cells, and that this process not only kills cells but also induces large amounts of ROS ... See full document

... The antioxidant capacity was determined using the homogenate brain rat that is rich in phospholipids, these suffer peroxidative processes (catalyzed or not by metals) that can be measured by the increment the levels of ... See full document

... nanomaterials for novel applications is increasing exponentially. To date, the scientific basis for the cytotoxicity and genotoxicity of most manufactured nanomaterials are not understood. The mechanisms underlying the ... See full document

... . The main enzyme system responsible for ROS production from phagocytic cells is the family of nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs) which consist of seven members from NOX (1 to 5) and two ... See full document

... reduce oxygen. Such a reaction is taken to be a hyperbolic function of oxygen concentration and proportional to the concentrations of forms able to donate an ... See full document

... leads to electron leakage in the electron transfer chain and subsequently produces ROS. The Ca 2+ -dependent NADPH oxidase, called NOX5 (encoded by the NOX5 gene) was initially detected in the human testis, but ... See full document

... Data on the basic processes and the compart- ments, involved in formation of reactive oxygen spe - cies (ROS) in plant cells, are generalised. The fea - tures of structure and regulation of NADPH­oxidase as ... See full document

... which has been linked to many pathological processes, including male infertility [1-3]. In the genital tract, low levels of ROS are necessary for normal function of human spermatozoa [4], including their ... See full document

... We were able to localize the defect in Rac2 activation to a plasma membrane-associated component (Figure 4b). Our data do not support a model in which Rac might be sequestered by membrane integrins, as we did not observe ... See full document

... Oxygen is now the most prevalent element in the earth’s crust [15]. It exists in air as a diatomic molecule, O 2 . Except for a small number of anaerobic bacteria, all living organisms use O 2 for energy ... See full document

... Pemetrexed induces caspase-dependent and -independent apoptosis in human melanoma cells through intracellular ROS accumulation, which in turn promotes DNA damage ... See full document

... reacts rapidly with macromolecules in the vicinity of where it is gen- erated, resulting in oxidation that is often referred to as “ damage ” (Apel and Hirt, 2004; Watabe et al., 2007). Much of the oxidative inactiva- ... See full document

... of oxygen species by way of DFT (see ESI† for details), as the energies of the gas phase reactant and product are constants and only the adsorption energy of the oxygen species involved in the ... See full document