[PDF] Top 20 Human herpesvirus–encoded kinase induces B cell lymphomas in vivo
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Human herpesvirus–encoded kinase induces B cell lymphomas in vivo
... in vivo models in which KSHV lytic or latent proteins are expressed support this ...of B cell development results in a high inci- dence of B cell–derived lymphoma ... See full document
17
Human Herpesvirus 8-Encoded Thymidine Kinase and Phosphotransferase Homologues Confer Sensitivity to Ganciclovir
... Human herpesvirus 8 (HHV-8) is a gammaherpesvirus found in Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL), and in some cases of multicentric Castleman’s disease (10, 14, ...of human ... See full document
8
Pre-clinical blocking of PD-L1 molecule, which expression is down regulated by NF-κB, JAK1/JAK2 and BTK inhibitors, induces regression of activated B-cell lymphoma
... of B-cell lymphomas, especially for those with activation of NF- κ ...by B-cell specific CD40 signaling responsible for NF- κ B continuous activation with a spleen monoclonal ... See full document
8
Carboxy Terminus of Human Herpesvirus 8 Latency-Associated Nuclear Antigen Mediates Dimerization, Transcriptional Repression, and Targeting to Nuclear Bodies
... Human herpesvirus 8 (HHV-8; also known as Kaposi’s sarcoma-associated herpesvirus) is the causative agent of Kaposi’s sarcoma and certain B-cell ...(LANA) encoded by open read- ... See full document
9
The Infected Cell Protein 0 Encoded by Bovine Herpesvirus 1 (bICP0) Induces Degradation of Interferon Response Factor 3 and, Consequently, Inhibits Beta Interferon Promoter Activity
... is cell type depen- dent (44), suggesting that in certain cell types HSV-1 produc- tive infection can reduce IRF3 protein levels in an ICP0-de- pendent ...in human or bovine cells. In contrast to ... See full document
10
A Kaposi's Sarcoma-Associated Herpesvirus-Encoded Ortholog of MicroRNA miR-155 Induces Human Splenic B-Cell Expansion in NOD/LtSz-scid IL2Rγnull Mice
... Luciferase assays and reporter construction. miRNA sensor vectors were created using the pGL3 promoter vector from Promega (Madison, WI). Syn- thetic oligonucleotides containing two complete complementary copies of a ... See full document
10
Kaposi's Sarcoma-Associated Herpesvirus Induces Sustained NF-κB Activation during De Novo Infection of Primary Human Dermal Microvascular Endothelial Cells That Is Essential for Viral Gene Expression
... sarcoma-associated herpesvirus (KSHV) infection of primary human dermal microvascu- lar endothelial (HMVEC-d) cells and human foreskin fibroblast (HFF) cells is characterized by the induction of ... See full document
20
Human Herpesvirus 6B Induces Hypomethylation on Chromosome 17p13.3, Correlating with Increased Gene Expression and Virus Integration
... JJhan cell line during productive infection (11), which is in line with the timeline observed in this ...in vivo, DNA extracted from 12 HHV-6B DNA-positive and 11 HHV-6B DNA-negative hippocam- pus samples ... See full document
14
Distinct p53, p53:LANA, and LANA Complexes in Kaposi's Sarcoma-Associated Herpesvirus Lymphomas
... regulate cell proliferation, induce cell transformation, and pre- vent cell ...for human telomerase ...Likewise, B cell-specific expression of LANA in transgenic mice ... See full document
11
The Kaposi's Sarcoma-Associated Herpesvirus G Protein-Coupled Receptor Has Broad Signaling Effects in Primary Effusion Lymphoma Cells
... inflammation, cell cycle regulation, and angiogenesis (12, 14, 60, 74, ...the human interleukin-8 (IL-8) receptors CXCR1 and CXCR2 as well as to the GPCR encoded by herpesvirus saimiri (ECRF3) ... See full document
11
In Vivo Models of Oncoproteins Encoded by Kaposi’s Sarcoma-Associated Herpesvirus
... in vivo, a transgenic mouse model was generated in which the K1 ORF is ubiquitously expressed under the transcriptional control of the simian virus 40 (SV40) promoter ...(79). B and T lymphocytes isolated ... See full document
11
Lipid Rafts of Primary Endothelial Cells Are Essential for Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8-Induced Phosphatidylinositol 3-Kinase and RhoA-GTPases Critical for Microtubule Dynamics and Nuclear Delivery of Viral DNA but Dispensable for Binding and Entry
... target cell infection by herpesviruses is a complex multistep event, which includes the initial attachment to the target cells involving multiple receptors and multiple viral proteins, followed by penetration or ... See full document
19
Human Herpesvirus 8 Induces Polyfunctional B Lymphocytes That Drive Kaposi’s Sarcoma
... of B cells was evident in vivo in relation to ...infected B cells based on expression of ORF59 PF-8 directly in archived MACS samples, we found that B cells of KS positives had a higher ... See full document
11
PLK1 stabilizes a MYC dependent kinase network in aggressive B cell lymphomas
... ex vivo and in vivo. DHL cell lines were treated with ABT-199 or volasertib, singly and in combination, and were subjected to cell viability and clonogenic growth ...DHL cell survival ... See full document
15
CBC Finding and LDH Estimation in Newly Diagnosed Patients with NHL
... also known as non-Hodgkin disease are diverse group of blood cancer that include any kind of lymphoma except Hodgkin's lymphoma .Types of NHL vary significantly in their severity, from slow growing to very aggressive ... See full document
14
Kaposi’s Sarcoma Associated Herpesvirus Encoded circRNAs Are Expressed in Infected Tumor Tissues and Are Incorporated into Virions
... anti-human IgM antibody (catalog no. 2020 – 01; SouthernBiotech) and grown for 4 to 5 days in Techne spinner flasks (Cole-Parmer GmbH, Wertheim, Germany) with 60 rpm agitation. Culture supernatant was collected ... See full document
16
Activation of p90 Ribosomal S6 Kinase by ORF45 of Kaposi's Sarcoma-Associated Herpesvirus and Its Role in Viral Lytic Replication
... h, cell lysates were prepared and analyzed by Western blotting with phosphorylation-specific antibodies to phospho-S221, phospho-T359/S363, phospho-S380, phospho-T573, and anti-Flag ...(B) Kinase ... See full document
13
B cell activation factor (BAFF) induces inflammation in the human fallopian tube leading to tubal pregnancy
... Tubal pregnancy is recognized as one of the most common ectopic pregnancy types [14]. It is well-known in humans, but is rarely diagnosed in animals [15]. The fallopian tubes provide the complex environment required for ... See full document
7
Tetraspanin CD37 protects against the development of B cell lymphoma
... in human B cell ...GC B cells and in DLBCL (53), whereas downregulation of CD9 has been related to lymphoma progression ...in human B cell lym- phomas did not reveal ... See full document
15
Breast implant-associated anaplastic large cell lymphoma in a Li-FRAUMENI patient: a case report
... T cell receptor gene rearrangements in the majority of cases and few cases with polyclonal rearrangements in immunoglobulin chain genes [10, ...atypical cell infil- trate: strong, diffuse expression of ... See full document
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