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[PDF] Top 20 Human immunodeficiency virus Tat associates with a specific set of cellular RNAs

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Human immunodeficiency virus Tat associates with a specific set of cellular RNAs

Human immunodeficiency virus Tat associates with a specific set of cellular RNAs

... by Tat encode a set of proteins enriched for specific functions including nucleotide bind- ing and tRNA metabolic ...HIV Tat should target these RNAs in particular but similar ... See full document

14

Potentiation of human immunodeficiency virus type 1 Tat by human cellular proteins.

Potentiation of human immunodeficiency virus type 1 Tat by human cellular proteins.

... The Tat protein is a potent activator of human immunodeficiency virus type 1 ...transcription. Tat has been shown to act by increasing both transcription initiation and elongation, but ... See full document

5

Inhibition of Human Immunodeficiency Virus Type 1 Replication in Primary Macrophages by Using Tat- or CCR5-Specific Small Interfering RNAs Expressed from a Lentivirus Vector

Inhibition of Human Immunodeficiency Virus Type 1 Replication in Primary Macrophages by Using Tat- or CCR5-Specific Small Interfering RNAs Expressed from a Lentivirus Vector

... indicator virus containing the luc indicator gene substituted for ...this virus is expressed in the absence of Rev function and is not predicted to contain the tat siRNA target ...indicator ... See full document

9

Amplification of the Inflammatory Cellular Redox State by Human Immunodeficiency Virus Type 1-Immunosuppressive Tat and gp160 Proteins

Amplification of the Inflammatory Cellular Redox State by Human Immunodeficiency Virus Type 1-Immunosuppressive Tat and gp160 Proteins

... . Specific inhibitors of NADPH enzymes seem to support the assumption that this enzyme is one of the main targets of our ...Also, human immunodeficiency virus type 1 (HIV-1) gp160 inhibits the ... See full document

6

Transcriptional trans activation by human immunodeficiency virus type 1 Tat requires specific coactivators that are not basal factors.

Transcriptional trans activation by human immunodeficiency virus type 1 Tat requires specific coactivators that are not basal factors.

... HIV-1 Tat-medi- ated transcriptional activation remains ...of Tat in both the initiation and elongation phases of transcription by RNA Pol ...of cellular factors. Here, we show the first direct ... See full document

10

Cellular tropism of human immunodeficiency virus: Receptors and inhibitors

Cellular tropism of human immunodeficiency virus: Receptors and inhibitors

... IN (xy32) Integrase is cleaved from the C-terminal end of Gag-Pol, and catalyses a series of reactions culminating in the integration of the viral DNA into the host cell genome (section 1.5.2.2). This integrated provirus ... See full document

297

Outcome of Simian-Human Immunodeficiency Virus Strain 89.6p Challenge following Vaccination of Rhesus Macaques with Human Immunodeficiency Virus Tat Protein

Outcome of Simian-Human Immunodeficiency Virus Strain 89.6p Challenge following Vaccination of Rhesus Macaques with Human Immunodeficiency Virus Tat Protein

... region. Tat-specific T-helper responses were detected in 50% of immunized ...addition, Tat-specific gamma interferon responses were detected in CD4 ⴙ and/or CD8 ⴙ T lymphocytes in 11 of 16 ... See full document

10

A Second-Site Mutation That Restores Replication of a Tat-Defective Human Immunodeficiency Virus

A Second-Site Mutation That Restores Replication of a Tat-Defective Human Immunodeficiency Virus

... of Human Retrovirology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands Received 21 September 1998/Accepted 14 December 1998 We previously constructed a large set of ... See full document

9

Endoribonuclease-Prepared Short Interfering RNAs Induce Effective and Specific Inhibition of Human Immunodeficiency Virus Type 1 Replication

Endoribonuclease-Prepared Short Interfering RNAs Induce Effective and Specific Inhibition of Human Immunodeficiency Virus Type 1 Replication

... interfering RNAs (siRNAs) targeting viral or cellular genes can efficiently inhibit human immunodeficiency virus type 1 (HIV-1) ...sequence specific because several irrelevant ... See full document

7

Human immunodeficiency virus Tat transactivation: induction of a tissue-specific enhancer in a nonpermissive cell line.

Human immunodeficiency virus Tat transactivation: induction of a tissue-specific enhancer in a nonpermissive cell line.

... In the presence of Tat, the JCV enhancer is functional in cells normally nonpermissive for JCV expression; therefore, our results provide unique evidence that HIV type 1 Tat may regulate[r] ... See full document

6

Regulation of Human Immunodeficiency Virus Type 1 Gene Expression by Clade-Specific Tat Proteins

Regulation of Human Immunodeficiency Virus Type 1 Gene Expression by Clade-Specific Tat Proteins

... clade-specific Tat proteins. For the present study, we examined clade-specific interactions between Tat, transactivation-responsive (TAR) element, and P-TEFb proteins and how these ... See full document

12

Molecular determinants for cellular uptake of Tat protein of human immunodeficiency virus type 1 in brain cells.

Molecular determinants for cellular uptake of Tat protein of human immunodeficiency virus type 1 in brain cells.

... extracellular Tat important in deter- mining its role in regulating viral and host function, but this phenomenon could also potentially be exploited to deliver heterologous proteins or drugs into ...full-length ... See full document

5

Structural and functional characterization of human immunodeficiency virus tat protein.

Structural and functional characterization of human immunodeficiency virus tat protein.

... The tat proteins that contained alterations within the cluster of positively charged amino acid residues retained their ability to transactivate gene expression, albeit at markedly reduc[r] ... See full document

8

Modulation of Sp1 Phosphorylation by Human Immunodeficiency Virus Type 1 Tat

Modulation of Sp1 Phosphorylation by Human Immunodeficiency Virus Type 1 Tat

... inactive Tat mutants that compete with wild-type Tat for Sp1 contact and ones that repress HIV-1 replication in cultured T cells ...wild-type Tat-Sp1 contact is physiologically important for pro- ... See full document

15

Human immunodeficiency virus Tat induces functional unresponsiveness in T cells.

Human immunodeficiency virus Tat induces functional unresponsiveness in T cells.

... Soluble Tat proteins secreted by HeLa cells transfected with the tat gene also inhibited antigen-induced proliferation of the T-cell ...clones. Tat inhibited the anti-CD3 monoclonal antibody-induced ... See full document

7

Synergistic activation of the human immunodeficiency virus type 1 promoter by the viral Tat protein and cellular transcription factor Sp1.

Synergistic activation of the human immunodeficiency virus type 1 promoter by the viral Tat protein and cellular transcription factor Sp1.

... We have previously shown that the human immunodeficiency virus type 1 (HIV-1) Tat protein can activate a synthetic promoter containing consensus-binding sites for the cellular transcript[r] ... See full document

5

Factors affecting cellular tropism of human immunodeficiency virus.

Factors affecting cellular tropism of human immunodeficiency virus.

... To evaluate the basis of the slow growth of many human immunodeficiency virus strains in monocytes/ macrophages, various stages of the virus life cycle have been studied for their possib[r] ... See full document

5

Orientation-specific cis complementation by bulge- and loop-mutated human immunodeficiency virus type 1 TAR RNAs.

Orientation-specific cis complementation by bulge- and loop-mutated human immunodeficiency virus type 1 TAR RNAs.

... Structural requirements of trans activation of human immu- nodeficiency virus type 1 long terminal repeat-directed gene expression by tat: importance of base pairing, loop sequences, and[r] ... See full document

5

Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription.

Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription.

... NF-KB is a protein complex which functions in concert with the tat-I gene product to stimulate human immunodeficiency virus (HIV) transcription.. To determine whether specific members of[r] ... See full document

5

Structure and expression of tat-, rev-, and nef-specific transcripts of human immunodeficiency virus type 1 in infected lymphocytes and macrophages.

Structure and expression of tat-, rev-, and nef-specific transcripts of human immunodeficiency virus type 1 in infected lymphocytes and macrophages.

... Southern blots of amplified cDNA from H9 cells chroni- cally infected with the HTLV-IIIB strain of HIV-1 were hybridized with the different probes.. The most prominent band detected with[r] ... See full document

8

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