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[PDF] Top 20 (5R) 5 Hydroxytriptolide (LLDT 8) inhibits osteoclastogenesis via RANKL/RANK/OPG signaling pathway

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(5R) 5 Hydroxytriptolide (LLDT 8) inhibits osteoclastogenesis via RANKL/RANK/OPG signaling pathway

(5R) 5 Hydroxytriptolide (LLDT 8) inhibits osteoclastogenesis via RANKL/RANK/OPG signaling pathway

... calcium signaling downstream of RANK by suppressing the transcription of TREM-2 ...which inhibits osteoclasts for- mation by stimulating osteoblasts to produce OPG ...formation via ... See full document

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<p>Baicalin Ameliorates Dexamethasone-Induced Osteoporosis by Regulation of the RANK/RANKL/OPG Signaling Pathway</p>

<p>Baicalin Ameliorates Dexamethasone-Induced Osteoporosis by Regulation of the RANK/RANKL/OPG Signaling Pathway</p>

... of RANKL, these data further demon- strate that BA ameliorates DEX-induced osteoporosis by regulation of the RANK/RANKL/OPG signaling ... See full document

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Original Article Effect of TNF-α on osteoporosis by regulating the RANKL/OPG signaling pathway

Original Article Effect of TNF-α on osteoporosis by regulating the RANKL/OPG signaling pathway

... for RANKL, OPG can competitively bind to RANKL, thereby inhibiting the binding of RANKL and RANK, resulting in inhibition of osteoclast dif- ferentiation and ...KL/OPG ... See full document

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Original Article The mechanism of quercetin in regulating osteoclast activation and the PAR2/TRPV1 signaling pathway in the treatment of bone cancer pain

Original Article The mechanism of quercetin in regulating osteoclast activation and the PAR2/TRPV1 signaling pathway in the treatment of bone cancer pain

... PAR2/TRPV1 pathway in ...the RANKL, OPG, RANK, PTHrP and IGF-1 proteins in rat bone tissue, the inflammatory mediators IL-8, M-CSF and TNF-α, and the PAR2/TRPV1 pathway-related ... See full document

8

Gene polymorphisms in RANKL/RANK/OPG pathway are associated with ages at menarche and natural menopause in Chinese women

Gene polymorphisms in RANKL/RANK/OPG pathway are associated with ages at menarche and natural menopause in Chinese women

... to RANKL/RANK/OPG signaling pathway. RANKL plays an important role in mammary gland development, indicating its potential role in regu- lating or responding to sex hormone ... See full document

7

Achyranthes bidentata extract exerts osteoprotective effects on steroid induced osteonecrosis of the femoral head in rats by regulating RANKL/RANK/OPG signaling

Achyranthes bidentata extract exerts osteoprotective effects on steroid induced osteonecrosis of the femoral head in rats by regulating RANKL/RANK/OPG signaling

... the RANKL/ RANK/OPG signaling pathway ...[25,26]. RANK and its lig- and RANKL are crucial regulators of osteoclast differenti- ...conditions, RANKL is expressed in ... See full document

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Original Article Punicalagin inhibits RANKL-induced osteoclastogenesis by suppressing NF-κB and MAPK signaling pathways

Original Article Punicalagin inhibits RANKL-induced osteoclastogenesis by suppressing NF-κB and MAPK signaling pathways

... [8]. RANKL is a tumor necrosis factor (TNF) superfamily mem- ber. RANKL-induced activation of cell surface receptor RANK leads to stimulation of TNF receptor-associated factors (TRAF) 1, 2, 3, ... See full document

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Negative regulation of osteoclastogenesis and bone resorption by cytokines and transcriptional repressors

Negative regulation of osteoclastogenesis and bone resorption by cytokines and transcriptional repressors

... Notch signaling pathway regulates cell proliferation, diff erentiation and ...during RANKL-induced osteoclastogenesis ...Notch signaling pathway inhibits ... See full document

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Atorvastatin inhibits osteoclastogenesis by decreasing the expression of RANKL in the synoviocytes of rheumatoid arthritis

Atorvastatin inhibits osteoclastogenesis by decreasing the expression of RANKL in the synoviocytes of rheumatoid arthritis

... of RANKL expression by statins is prevented by ...and RANKL plays an important role in differentiation of osteoclasts from their precursor cells and promotes the activity and survival of these cells, which ... See full document

9

Puerarin inhibits the osteoclastogenesis by inhibiting RANKL dependent and –independent autophagic responses

Puerarin inhibits the osteoclastogenesis by inhibiting RANKL dependent and –independent autophagic responses

... of RANKL, which could be reversed by the overexpression of au- tophagic ...of RANKL, only BECN1 reversed Puerarin-inhibited osteoclast ...of RANKL on OCP autoph- ...effectively inhibits the ... See full document

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Frequency of CD19+ CD5+ B lymphocytes among Egyptian Patients with Rheumatoid Arthritis and Their Correlation with Disease Activity and Bone Resorption

Frequency of CD19+ CD5+ B lymphocytes among Egyptian Patients with Rheumatoid Arthritis and Their Correlation with Disease Activity and Bone Resorption

... The present study was enrolled 34 RA patients (mean age 41.91 ± 6.75 years ranged from 29 to 52 years; 88.2% females) and 20 age and sex matched healthy controls (mean age 43.25 ± 6.32 years; 80.0% females) p > 0.05. ... See full document

10

Osteoprotective effects of vitamin D(3) in diabetic mice is VDR-mediated and regulated via RANKL/RANK/OPG axis

Osteoprotective effects of vitamin D(3) in diabetic mice is VDR-mediated and regulated via RANKL/RANK/OPG axis

... animals. All studies were conducted on 4-month-old male C56Bl/J6 mice weighing 21 ± 3 g. T1D was induced by multiple (5 times) injections of streptozotocin (STZ, Sigma-Aldrich, USA) at a dose of 40 mg/kg body ... See full document

10

Osteoimmunology at the nexus of arthritis, osteoporosis, cancer, and infection

Osteoimmunology at the nexus of arthritis, osteoporosis, cancer, and infection

... Reduces inflammation; limits bone erosion by decreasing RANKL-mediated osteoclastogenesis Reduces inflammation; limits bone erosion by decreasing RANKL-mediated osteoclastogenesis Reduce[r] ... See full document

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Original Article Eleutherococcus senticosus Inhibits RANKL-induced osteoclast formation by attenuating the NF-κB and MAPKs signaling pathway

Original Article Eleutherococcus senticosus Inhibits RANKL-induced osteoclast formation by attenuating the NF-κB and MAPKs signaling pathway

... the RANKL-RANK axis appears to be essential for osteoclasto- genesis, and costimulatory immunoreceptors lead to robust induction of c-Fos and NFATc1, which are the necessary and sufficient tran- scription ... See full document

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RANKL/RANK/OPG system beyond bone remodeling: involvement in breast cancer and clinical perspectives

RANKL/RANK/OPG system beyond bone remodeling: involvement in breast cancer and clinical perspectives

... same pathway. First, the expression of RANKL and RANK has been documented in breast cancer cell lines and in human breast cancers [23, 24, ...Moreover, RANK expression in tumor tissue has been ... See full document

18

Original Article Berberine suppresses osteoclastogenesis and osteolysis in a mouse model

Original Article Berberine suppresses osteoclastogenesis and osteolysis in a mouse model

... The RANKL/RANK/osteoprotegerin (OPG) sys- tem is an important recent discovery in the osteoclast ...field. RANK combined with RANKL can activate signaling in precursor cells and ... See full document

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Serum levels of osteoprotegerin and receptor activator of nuclear factor -κB ligand in children with early juvenile idiopathic arthritis: a 2-year prospective controlled study

Serum levels of osteoprotegerin and receptor activator of nuclear factor -κB ligand in children with early juvenile idiopathic arthritis: a 2-year prospective controlled study

... of RANKL/OPG in a dose- dependent manner ...increased OPG expression and decreased RANKL expression ...increased OPG/RANKL ratio in DMARDs treated and corticoster- oid treated ... See full document

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Cancer-associated fibroblasts promote bone invasion in oral squamous cell carcinoma

Cancer-associated fibroblasts promote bone invasion in oral squamous cell carcinoma

... TGF-b1 stimulates RANKL expression in primary fibroblasts. We next sought to determine if experimentally derived myofibro- blastic CAF secrete RANKL. Previous work in our laboratory has indicated that ... See full document

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Evaluating the effects of pine bark extract supplementation on bone turnover and the possible mechanisms of OPG/RANKL signaling in postmenopausal osteopenic women: a trial protocol

Evaluating the effects of pine bark extract supplementation on bone turnover and the possible mechanisms of OPG/RANKL signaling in postmenopausal osteopenic women: a trial protocol

... [22]. RANKL and osteoprotegerin (OPG) are cytokines that may modulate bone remodeling via the receptor activator of the NF- κB ...the RANKL/RANK signaling system. Also, this ... See full document

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NF κB p100 limits TNF induced bone resorption in mice by a TRAF3 dependent mechanism

NF κB p100 limits TNF induced bone resorption in mice by a TRAF3 dependent mechanism

... TNF-induced osteoclastogenesis (14) and TRAF5 is involved in both RANKL- and TNF-induced osteoclastogenesis (15), others have found that TRAF2- or TRAF5-deficient OCPs can differentiate into mature ... See full document

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