[PDF] Top 20 Hypothalamic resistin induces hepatic insulin resistance

... in insulin-sensi- tive organs ...and insulin, exert some of their gluco-regulatory actions through the activation of hypothalamic ...hormone resistin also exerts some of its metabolic actions ... See full document

... Hypothalamic overexpression of CA-S6K blunts Akt phosphorylation. After 5 h of fasting, 4 μ U insulin was infused into the MBH, and 15 min later, the MBH was harvested and analyzed. MBH lysates were blotted ... See full document

... attenuates insulin-induced sup- pression of hepatic glucose ...carotid-artery insulin infusion under euglycemic clamp condi- ...plasma insulin values of approximately 900 pmol/l (data not ... See full document

... causes insulin resist- ance in human skeletal muscle remains ...fat induces insulin resistance by increasing the NADH/NAD and fatty acyl CoA/CoA ratios, leading to a reduction in pyruvate ... See full document

... of hepatic insulin resistance by dietary stearate remains to be ...stearate induces hepatic insulin resistance independent of food ...induce insulin ... See full document

... age-related insulin resistance ...exquisitely insulin sensitive, even when challenged with HFD or supraphysiologic amounts of ...line induces recombinase activity in the peripheral and central ... See full document

... Insulin resistance manifests itself differentially in vari- ous tissues, which contributes to the overall phenotype of ...example, insulin resistance in: (1) WAT, results in lipolysis, ... See full document

... expressing resistin exhibited impaired insulin-mediated glucose transport ...affecting insulin receptor signalling, therefore acting by reducing the intrinsic activity of cell-surface glucose ... See full document

... That the impairment of insulin signal- ing occurs in the remote organs follow- ing MI is certainly recognized but poorly understood. Since circulating and local inflammatory cytokines are always ele- vated after ... See full document

... and insulin resistance provides the strongest etiological thread ...to insulin resistance is particularly ...7). Resistin is an adipose-derived circulating protein and belongs to a new ... See full document

... complex hepatic hormone that is highly regulated by various metabolic challenges, includ- ing fasting, high-fat, low-carbohydrate, low-protein, and low–essential amino acid diets (1, ...to insulin, as ... See full document

... and hepatic fibrosis in these animals ...in hepatic stellate cells (HSCs) derived from MCD diet-fed rats ...with hepatic pro-inflammatory gene expression as well as grade of steatosis and ... See full document

... and insulin resistance ...displayed insulin resistance without accompanying body weight changes compared with control mice under HFD ...to insulin resistance in Atg7KO mice, ... See full document

... reduce hepatic malonyl-CoA levels in vivo, lower hepatic lipids (long-chain acyl-CoAs, diacylglycerol, and triglycerides), and improve hepatic insulin ...increases hepatic fat oxidation ... See full document

... with insulin resistance, obesity, metabolic syndrome, and ...obesity, insulin resistance, metabolic disorder are related with increased gallbladder disease, as all these factors similarly are ... See full document

... Prednisone-induced insulin resistance may depend on either reduced sensitivity (receptor defect) or reduced response to insulin (postreceptor ...prednisone-induced insulin resistance, a ... See full document

... and resistin may be useful markers for insulin resistance and the variables that can integrate the abnormalities of the metabolic syndrome and cardiometabolic ...of insulin resistance, ... See full document

... Genistein, a soy isoflavone found in soybeans, has received more consistent favorable literature reviews than n-3 PUFAs. When provided concurrently with a maternal HF diet and comprising 0.2% (by weight) of total ... See full document

... by hepatic insulin resis- tance and the metabolic factors which induce ...improve hepatic insulin sensitivity, as catalogued above, could be expected to decrease elevated TMAO–a proposition ... See full document

... ent insulin concentrations and insulin clearance, may play a primary ...their hepatic oxidation provides the energy needed to drive gluconeogenesis, and lower FFA release from hepatic fat ... See full document