[PDF] Top 20 Icaritin induces lytic cytotoxicity in extranodal NK/T-cell lymphoma

... Icaritin in DMSO (Sigma, Louis, MO, USA) and stored at −20°C. The final concentration of DMSO in the treat- ment medium was controlled below 0.1%. GCV was pur- chased from Hubei Ke Yi Pharmaceutic Co., Ltd (Hubei, ... See full document

... Extranodal NK/T-cell lymphoma nasal type (ENKL) is a rare type of non-Hodgkin lymphoma that more frequently occurs in East Asia and Latin ...cancer cell lines), targeted ... See full document

... Extranodal NK/T-cell lymphoma, nasal type (ENKL) is a subtype associated with Epstein-Barr virus (EBV) infection and commonly involves the upper respiratory tract, such as the nasal ... See full document

... the NK/T-cell type as proven by immu- nohistochemical, flow cytometry, or EBV in situ hybridization ...with extranodal NK/T-cell lymphoma without lymphomatous ... See full document

... Extranodal NK/T-cell lymphoma, nasal type (ENKL), is an uncommon subtype of EBV associated lymphoma usually characterized by aggressive clinical ...and T-cell EBV ... See full document

... as extranodal NK/T- cell lymphoma-associated HLH and treated in Shanghai Cancer Center, China from January 2006 to July 2017, were included in this retrospective ...of ... See full document

... single cell suspension ex vivo: anti-CD4 (Clone RPA-T4), anti-CD25 (BC96), anti-CCR6 (R6H1), an- ti-IL17 (SCPL1362), anti-FOXP3 (236A/E7), anti-IFN (B27), anti-IL-2 (M11-17H12), anti-IL-10 (JES3-19F1), anti-CCR7 ... See full document

... closely associated with EBV infection and abnormal ex- pression of latent membrane protein products encoded by EBV [8-11]. Among these protein products, LMP1 is the most significant oncogenic protein which partici- pates ... See full document

... killer cell leukemia/lymphoma (ANKL) is a highly rare and extremely aggressive malignancy of NK cells initially classified as a type of large granular lymphocytic leukemia in 1986 ...Hodgkin ... See full document

... on lymphoma cells (Figure 2A, ...in lymphoma cells of ENKTL, a previous in vitro study with AIDS-related non-Hodgkin lymphoma cell lines demon- strated migration of lymphoma cells ... See full document

... lymphocytes than normal cells, leading to a decrease in lymphocytes [26–28], which probably explained why the LMR level in high LMR group decreased significantly when treatment response was achieved in the present study, ... See full document

... (stage III/IV), the clinical course is highly aggressive, with frequent CT resistance and poor outcome. CHOP- based therapy [18,19] was often used, but associated without satisfactory results. However, recent combin- ... See full document

... in cell cycle control, apoptotic response and DNA repair, such as checkpoint kinase 2 (Chk2), ...to cell senescence and apoptosis, resulting in delay or prevention of tumorigenesis [26, ... See full document

... distinctive T-/NK-cell lym- phoma characterized by tissue necrosis, frequent angioinvasion, EBV association, expression of cytotoxic molecule (TIA-1), cytoplasmic CD3, and CD56 but lack- ing ... See full document

... B-cell lymphoma is due to genomic amplification [40], no genomic amplifi- cations or translocations of the Xq12 locus have been re- ported in several genome-wide analyses of NK/T-cell ... See full document

... killer lymphoma (PINK), which includes age > 60 years, stage III or IV disease, distant lymph node involvement, and nonnasal disease, is used as a prognostic model for patients with ENKTL ... See full document

... in lymphoma has been examined in several ...B cell-like diffuse large B cell lymphoma (ABC-DLBCL) [92, ...in NK neoplasms as ...-null NK cell lines led to the suppression ... See full document

... with larger sample sizes are urgently required. Currently, we are still recruiting more patients in our center to more accurately evaluate the clinical ef fi cacy and safety of the DDGP regimen. Along with the rapid ... See full document

... peripheral T-cell lymphomas (PTCLs) have been associated with viral infection, particularly infection with Epstein-Barr virus ...and T-cell re- ceptor diversity paradigms across PTCL ... See full document

... of extranodal NK/T-cell lymphoma appear to be genuine NK-cell neo- plasm, while some cases show cytotoxic T-cell ...cytotoxic T-cell lym- phoma ... See full document