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[PDF] Top 20 Identification and characterization of a G protein-coupled receptor homolog encoded by murine cytomegalovirus.

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Identification and characterization of a G protein-coupled receptor homolog encoded by murine cytomegalovirus.

Identification and characterization of a G protein-coupled receptor homolog encoded by murine cytomegalovirus.

... human cytomegalovirus (HCMV) several years ago revealed three homologs of cellular G protein-coupled receptors (GCRs) encoded by the UL33, US27, and US28 genes ...activating G ... See full document

9

Epstein-Barr Virus-Encoded BILF1 Is a Constitutively Active G Protein-Coupled Receptor

Epstein-Barr Virus-Encoded BILF1 Is a Constitutively Active G Protein-Coupled Receptor

... acquired G pro- tein-coupled receptors (GPCRs), some of which are functional chemokine receptors ...e.g., cytomegalovirus (CMV), encode GPCR homologs, it is the general notion that ␥ 1-herpesviruses, ... See full document

11

Activation of Intracellular Signaling Pathways by the Murine Cytomegalovirus G Protein-Coupled Receptor M33 Occurs via PLC-β/PKC-Dependent and -Independent Mechanisms

Activation of Intracellular Signaling Pathways by the Murine Cytomegalovirus G Protein-Coupled Receptor M33 Occurs via PLC-β/PKC-Dependent and -Independent Mechanisms

... strictly G protein coupling (1, 3, 26, ...virally encoded GPCRs are functionally important in vivo in animal models of herpesvirus infection (5, 6, 21, 45, ...GPCR homolog M33, which is highly ... See full document

12

Late expression of a beta chemokine homolog by murine cytomegalovirus.

Late expression of a beta chemokine homolog by murine cytomegalovirus.

... Human cytomegalovirus (HCMV) is a ubiquitous human pathogen which, like other members of the herpesvirus family, establishes a lifelong infection in its ...related murine cytomegalovirus (MCMV) is ... See full document

8

The Murine Cytomegalovirus Chemokine Homolog, m131/129, Is a Determinant of Viral Pathogenicity

The Murine Cytomegalovirus Chemokine Homolog, m131/129, Is a Determinant of Viral Pathogenicity

... Human cytomegalovirus (HCMV), herpesvirus saimiri, human herpesvirus 6 (HHV-6), and HHV-8 each encode a functional chemokine receptor that, like their cellular counter- parts, is coupled to G ... See full document

10

Role of ORF74-Encoded Viral G Protein-Coupled Receptor in Human Herpesvirus 8 Lytic Replication

Role of ORF74-Encoded Viral G Protein-Coupled Receptor in Human Herpesvirus 8 Lytic Replication

... viral G protein- coupled receptors (vGPCRs), structurally related to chemo- kine receptors, some of which are directly orthologous and others of which are evolutionarily distinct (12, 17, ...by ... See full document

6

Deletion of the R78 G Protein-Coupled Receptor Gene from Rat Cytomegalovirus Results in an Attenuated, Syncytium-Inducing Mutant Strain

Deletion of the R78 G Protein-Coupled Receptor Gene from Rat Cytomegalovirus Results in an Attenuated, Syncytium-Inducing Mutant Strain

... exclusively encoded by betaherpesvi- ruses: HCMV UL33 (23), rat cytomegalovirus (RCMV) R33 (9), murine cytomegalovirus (MCMV) M33 (54), and human herpesvirus 6 and 7 (HHV-6 and -7) U12 (33, ... See full document

13

The M33 G Protein-Coupled Receptor Encoded by Murine Cytomegalovirus Is Dispensable for Hematogenous Dissemination but Is Required for Growth within the Salivary Gland

The M33 G Protein-Coupled Receptor Encoded by Murine Cytomegalovirus Is Dispensable for Hematogenous Dissemination but Is Required for Growth within the Salivary Gland

... kinase C (PKC), nuclear factor kappa light-chain enhancer of ac- tivated B cells (NF-␬B), nuclear factor of activated T cells (NF- AT), and cyclic AMP response element binding protein (CREB) (29–32). M33 is not ... See full document

14

The M33 Chemokine Receptor Homolog of Murine Cytomegalovirus Exhibits a Differential Tissue-Specific Role during In Vivo Replication and Latency

The M33 Chemokine Receptor Homolog of Murine Cytomegalovirus Exhibits a Differential Tissue-Specific Role during In Vivo Replication and Latency

... through G proteins (56, ...chemokine homolog (UL147) whose function is not yet known; a viral CC chemokine (UL131) that is critical for infection of macro- phages, endothelial cells, and epithelial cells ... See full document

12

The Rat Cytomegalovirus R33-Encoded G Protein-Coupled Receptor Signals in a Constitutive Fashion

The Rat Cytomegalovirus R33-Encoded G Protein-Coupled Receptor Signals in a Constitutive Fashion

... The identification of agonists and, in particular, inverse ago- nists of constitutive viral GPCR signaling might provide valu- able tools for elucidation of the role of this constitutive activity in the ... See full document

11

COMPUTATIONAL ANALYSIS OF G PROTEIN COUPLED RECEPTOR SCREENING, DIMERIZATION, AND DESENSITIZATION

COMPUTATIONAL ANALYSIS OF G PROTEIN COUPLED RECEPTOR SCREENING, DIMERIZATION, AND DESENSITIZATION

... that protein dimerization can cause long range ordering within the cell ...membrane, protein-protein interactions are likely to play a key role in establishing this order and dynamically changing ... See full document

206

Complete reversible refolding of a G-protein coupled receptor on a solid support

Complete reversible refolding of a G-protein coupled receptor on a solid support

... C-terminus (after residue Leu367) and contains a C-terminal tag of six histidine residues for purification. A segment, comprising residues 244 – 271, is also deleted. The construct contains eight point mutations: C116L ... See full document

16

Computational Predictions of G Protein Coupled Receptor Structures and Binding Sites

Computational Predictions of G Protein Coupled Receptor Structures and Binding Sites

... AIDS. 3 The mechanics of HIV viral attachment and entry suggest an important role for CXCR4 as a potential drug target to combat the AIDS epidemic. Two main methods to prevent the spread of HIV via targeting CXCR4 have ... See full document

122

Modulation of G Protein-Coupled Receptor Intracellular Trafficking and Signal Transduction

Modulation of G Protein-Coupled Receptor Intracellular Trafficking and Signal Transduction

... factor receptor 1, somatostatin-3 receptor, vasopressin V2 receptor, neurokinin-1 receptor, chemokine CXC receptor-2, m4 muscarinic acetylcholine receptor and protease ... See full document

223

Functional characterisation of the Anopheles leucokinins and
their cognate G protein coupled receptor

Functional characterisation of the Anopheles leucokinins and their cognate G protein coupled receptor

... their receptor in a genus containing major human and animal disease ...leucokinin receptor is found only in the type II (stellate) cells, and (using a transgenic aequorin calcium reporter) the peptide is ... See full document

14

Regulation of bone formation and remodeling by G protein coupled receptor 48

Regulation of bone formation and remodeling by G protein coupled receptor 48

... heterotrimeric G-proteins (binding of GTP) and the regulation of intracellular second messengers, such as cAMP and intracellular Ca 2+ ...(LRR)-containing G-protein-coupled receptor 4 ... See full document

10

Identification of novel arthropod vector G protein coupled receptors

Identification of novel arthropod vector G protein coupled receptors

... terms G-protein coupled receptor activity (GO:0004930), G-protein coupled receptor sig- naling pathway (GO:0007186), and receptor activity (GO:0004872), and ... See full document

15

Identification and Characterization of Novel Variations in Platelet G-Protein Coupled Receptor (GPCR) Genes in Patients Historically Diagnosed with Type 1 von Willebrand Disease

Identification and Characterization of Novel Variations in Platelet G-Protein Coupled Receptor (GPCR) Genes in Patients Historically Diagnosed with Type 1 von Willebrand Disease

... A shortcoming of this study was the lack of availability of index cases for follow up ex vivo assessment of platelet function including RNA and flow cytometric analysis, since this would have allowed confirmation of the ... See full document

15

Human Cytomegalovirus pUS27 G Protein-Coupled Receptor Homologue Is Required for Efficient Spread by the Extracellular Route but Not for Direct Cell-to-Cell Spread

Human Cytomegalovirus pUS27 G Protein-Coupled Receptor Homologue Is Required for Efficient Spread by the Extracellular Route but Not for Direct Cell-to-Cell Spread

... Although we detected pUS27 on the cell surface in the sensitive biotinylation assay, it has been reported that the pro- tein’s localization is dynamic and that it is rapidly internalized. In transient transfection ... See full document

8

Identification and characterization of a filament-associated protein encoded by Amsacta moorei entomopoxvirus.

Identification and characterization of a filament-associated protein encoded by Amsacta moorei entomopoxvirus.

... the protein, analysis of the 430-bp fragment revealed two interest- ing features of the 5 9 end of the FALPE transcript: (i) the presence of a poly(A) tract about 20 nucleotides long at its 5 9 end and (ii) the ... See full document

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