[PDF] Top 20 Immune mediated thrombocytopenia of malaria
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Immune mediated thrombocytopenia of malaria
... Thrombocytopenia frequently complicates malarial infections but the mechanism has not been elucidated. We studied 28 patients with malarial infections and noted that 16 of 17 thrombocytopenic patients had elevated ... See full document
6
Anti-RhD immunoglobulin in the treatment of immune thrombocytopenia
... The largest body of evidence exists for the competitive inhibition and blockade of the mononuclear phagocytic system by sensitized red blood cells within the spleen. Evidence to support this as a major mechanism of the ... See full document
6
Hypersensitivity reaction and acute immune-mediated thrombocytopenia from oxaliplatin: two case reports and a review of the literature
... treatment was not resumed because of hypersensitivity reaction with concomitant mild thrombocytopenia; a presentation similar to patient 1. A serum sample for platelet antibody analysis was also sent to the ... See full document
8
Severe immune thrombocytopenia in chronic lymphocytic leukemia (CLL)
... CLL-associated immune dysregulation and leukemic cells are the dominant antigen-presenting cells that activate T-cells with ...severe thrombocytopenia, treatment options are limited and administration of ... See full document
5
Pathogenesis and Therapeutic Mechanisms in Immune Thrombocytopenia (ITP)
... be mediated by the reduced secretion of platelet-derived chemokines and cytokines, including epidermal growth factor (EFG), chemokine C-C motif ligand 5 (CCL5), and chemokine C-X-C motif ligand 5 (CXCL5) ... See full document
21
Romiplostim as a treatment for immune thrombocytopenia: a review
... “Immune thrombocytopenia” (ITP) is an autoimmune disorder that leads to peripheral destruction, as well as a decreased production of ...for thrombocytopenia in adults with ...treat ... See full document
8
Megakaryocytic dysfunction in immune thrombocytopenia is linked to autophagy
... ITP is a common autoimmune-mediated bleeding disease, in which platelet membrane proteins become antigenic, stimulate the immune system to produce anti- bodies, and eventually result in ... See full document
10
Clinical Significance of Positive Platelet Immunofluorescence Assay in Adult Immune Thrombocytopenia: a Cross Sectional Study
... Immune thrombocytopenia (ITP) is a relatively common hematologic disorder manifested by low platelet count due to immune-mediated platelet destruction and/or suppression of platelet ... See full document
8
Long-term safety and efficacy of romiplostim for treatment of immune thrombocytopenia
... and mediated by antiplatelet antibodies is a well- known mechanism causing low platelet counts in immune thrombocytopenia ...treat thrombocytopenia in adults, and most recently, children with ... See full document
8
Immune thrombocytopenia: improving quality of life and patient outcomes
... Abstract: Immune thrombocytopenia (ITP) is an immune-mediated disorder characterized by a reduced platelet count and patients may develop bruising or mucosal ... See full document
16
Role of romiplostim in splenectomized and nonsplenectomized patients with immune thrombocytopenia
... mediated via activation of its receptor, c-Mpl. The cloning and characterization of TPO led immediately to proposals regarding its potential therapeutic use. The first recombinant preparations to be evaluated were ... See full document
7
A rare case report of acyclovir-induced immune thrombocytopenia with tongue hematomas as the first sign, and a literature review
... the thrombocytopenia, DITP can be divided into two main categories, which are suppression of platelet production and increasing in clearance of peripheral ...DITP, immune DITP, and autoimmune DITP ...is ... See full document
5
Original Article Expression of CD11a in lymphocyte subpopulation in immune thrombocytopenia
... maintaining peripheral tolerance by suppress- ing both cell-mediated and antibody-mediated responses [31]. Evidence indicated that levels of circulating Tregs in patients with acute and chronic ITP have ... See full document
10
Clinicopathological Study of Non – Immune Thrombocytopenia
... with thrombocytopenia and ...The thrombocytopenia, apart from the immune mediated platelet destruction, could be aggravated due to dysplasia in megakaryocyte ... See full document
68
Effect of malaria infection on hematological profiles of people living with human immunodeficiency virus in Gambella, southwest Ethiopia
... in malaria infection and they play a major role in malaria ...anemia, thrombocytopenia and leukocytosis or leucopenia ...and thrombocytopenia [8] are commonly re- ported abnormalities ... See full document
8
Immune-mediated thrombocytopenia in horses infected with equine infectious anemia virus.
... Thrombocytopenia has been documented in some humans infected with HIV-1 and associated with immune complex deposition on platelets 17, anti-platelet antibody 42, and active infection of [r] ... See full document
10
T cell immune abnormalities in immune thrombocytopenia
... The induction of autoreactive T cell anergy may reverse T cell-mediated abnormal immunity in ITP. Cytotoxic T lymphocyte associated antigen 4-immunoglobulin (CTLA4-Ig) and/or cyclosporine A (CsA) can induce ... See full document
6
B Cell Activating Factor Characterization and Use as a Biomarker in Dogs with Primary Immune-Mediated Thrombocytopenia.
... or immune-mediated diseases in ...human immune-mediated diseases such as systemic lupus erythematosus and its use as a therapeutic target for that disease (Coquery et ... See full document
94
Thrombocytopenia in patients with melanoma receiving immune checkpoint inhibitor therapy
... Although inhibitors of PD-1 provide significant thera- peutic benefit, many immune-related adverse events (irAEs) have emerged with these therapies. The most common irAEs include dermatologic toxicities and ... See full document
6
Spotlight on romiplostim in the treatment of children with chronic immune thrombocytopenia: design, development, and potential place in therapy
... median age of 11.4 years treated with romiplostim at two institutions. Patients were treated for 6–44 months with 11 patients continuing to receive therapy. The majority of the patients (86%) achieved the endpoints of ... See full document
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