[PDF] Top 20 Immunohistochemical expression of HER 2 NEU, P53 & P63 in urothelial bladder carcinoma and its correlation with clinico-pathological variables

... The HER 2 NEU gene is located on chromosome 17q and encodes for a tyrosine kinase receptor which is thought to control cell growth and development (122,123) .... Its activation increases the ... See full document

... breast carcinoma remains poorly understood as the know- ledge about individual prognostic factors provides limited information ...and HER-2/neu overexpression and their possible ... See full document

... Urothelial carcinoma is the 7th most common cancer worldwide ...sive urothelial tumors have recurrences (or new occurrences), and 10% to 15% of these will progress to invasive cancer ...of ... See full document

... gene expression in vitro [18], DNA strand breakage [19], carcinogenic mutation of human bronchial tissue [20] and genomic instability of human osteoblasts ...the expression of genes involved in these pro- ... See full document

... Microvessel density (MVD) has been considered as an important prognostic factor in many solid tumours and also in carcinomas of bladder. (4) . Immunohistological methods can be used to identify the density of ... See full document

... Sex difference with male preponderance is correlating with others studies owing to risk factors such as smoking and drinkind are common among males. Gastric adeno carcinoma even thogh it is a disease of the 6 th ... See full document

... with bladder cancer present with disease confined to the mucosa or submucosa ...of bladder cancer in developed countries and it is responsible for tripling the risk of developing cancer and increases the ... See full document

... of p53 and p21 expression as biomark- ers to monitor the disease and compare the results with those of ...with bladder carcinoma and ten normal bladder biopsies from forensic ...for ... See full document

... P501S expression in 22/23 (96%) PC ...prostein expression in 111/ 118 (94%) primary and metastatic prostate ...no expression detected in 4,635 normal and malig- nant non-prostatic ...only 2/35 ... See full document

... 28 Her 2 neu is a transmembrane epidermal growth factor receptor protein also known as c ...erb2. Its overexpression was reported to have poorer outcome and it predicts the response to ... See full document

... p16 expression in bladder cancer has been studied pre- viously (Kruger et ...however, its prognostic significance is still un- ...p16 expression was linked to poor prognosis in bladder ... See full document

... co expression of HER-2/neu with oestrogen ...and HER- 2/neu do not response to tamoxifen treatment due to interaction of tyrosine kinase pathway with hormonal pathway ... See full document

... The incidence rates for gastric cancer have undergone a steady decline during the past decades. This downward trend is equally observed among both sexes and in high and low risk areas, but has been more pronounced in ... See full document

... Cox-2 expression didn’t show any significant difference in the survival, either overall or disease free ...Cox-2 expression does not have any prognostic significance in advanced oral and ... See full document

... adjust expression of angiogenesis- and chemotherapy resistance-relevant genes ...excessive expression of AEG-1 results in ex- pression of pro-angiogenic factors like pro- angiogenic factor-1, metal matrix ... See full document

... Krukenberg tumour is the most common form of ovarian metastatic carcinoma in young women often found in fourth decade. (44) It is defined as ovarian neoplasms in which signet ring cells account for atleast 10% of ... See full document

... Plasmacytoid carcinoma of the urinary bladder or plasmacytoid urothelial carcinoma (PUC) is a rare and only recently described histological variant of transitional cell carcinoma ... See full document

... These tumors are identified as carcinoma but further subclassification could not be done due to lack of differentiation. The tumor has diffuse arrangements by large anaplastic cells with minimal glandular pattern. ... See full document

... for HER-2/neu is usually homogenous, tumour heterogeneity is more common in gastric ...displaying HER-2/neu positivity. The heterogeneity of HER-2/neu ... See full document

... normal bladder tis- sues and IDO-positive cells were mostly found in the muscularis layer of bladders ...positive expression of IDO was detected in nor- mal bladder tissues by ... See full document