[PDF] Top 20 An Immunohistochemical and Molecular Study of Gastrointestinal Stromal Tumours

... An Immunohistochemical and Molecular Study of Gastrointestinal Stromal Tumours ORIGINAL ARTICLE An Immunohistochemical and Molecular Study of Gastrointestinal Stromal Tumours Y T Teong, B Sc *, S T Te[.] ... See full document

... Gastrointestinal stromal tumors (GISTs) are uncommon tumours which have relatively recently been separated from conventional leiomyomas, leiomyoblastomas, and leiomyosarcomas, based on their specific ... See full document

... phyllodes tumours, there is an important spectrum within the phyllodes group between benign and ...malignant tumours at each end of the spectrum can be identified ...the tumours which lie some where ... See full document

... in the balance between cell survival and proliferation away from apoptosis. The frequency of KIT mutations in GISTs varies in different studies, according to the tumour type, and probably because of differences in the ... See full document

... mesenchymal tumours are a group of tumours that originate from the mesenchymal stem cells of the gastrointestinal tract (GIT) and consist of gastrointestinal stromal tumours ... See full document

... of gastric tumors with imatinib in the adjuvant setting. As tumors with certain mutations such as PDGFRA D842V mostly have primary resist- ance to imatinib and sunitinib, patients should be offered participation in ... See full document

... borderline tumours and low-grade invasive carcinoma of the ovary [19, ...borderline tumours of the ovary and seem to be mutually exclusive ...recent study has shown a mutation of BRAF V600E in a ... See full document

... GIST, molecular analy- sis for activating mutations in KIT or PDGFRA may help confirm the ...to molecular-targeted therapy, and also prognostic ...new molecular pathology assess- ments can then be ... See full document

... for gastrointestinal stromal tumor (GIST) with co-pri- mary tumors, the synchronous appearance of a poorly differentiated neuroendocrine carcinoma (NEC) and GIST in the stomach is extremely ...current ... See full document

... of molecular targeted therapy with Imatinib, treatment of metastatic or recurrent GISTs is more effective and the survival rate has improved impressively ... See full document

... After the operation, patients who underwent gastric or duodenal surgery were placed in a semi-recumbent posi- tion, and fasted for 72 h. Gastrointestinal decompression, infection prevention, and acid suppression ... See full document

... The study was approved by the Ethics Committee of Hospital Germans Trias i Pujol (Spain), and was conducted in accordance with the Declaration of Helsinki and Spanish regulative law for Tumor ... See full document

... solid tumours, including ES [11]. In a phase II study including 31 ES patients [11], four showed partial response and two had prolonged stable disease, with a favourable drug ... See full document

... For symptomatic and persistent anaemia associated with imatinib, EPO may therefore be considered. Further studies investigating the impact on other measures, such as quality of life and fatigue are needed to measure the ... See full document

... whether operation is needed when early response is ac- quired in some cases without giving definite time frame in unresectable or locally advanced primary GIST [4]. Both 6 months of preoperative IM [5, 6] and waiting for ... See full document

... the gastrointestinal tract, and they have not been identified in the ...extra-gastrointestinal stromal tumors and con- cluded that with the discovery and characterization of pancreatic TCs, the ... See full document

... The occurrence of GISTs in the adrenal region is very rare and can be difficult to make differential diagnosis from nonfunctional adrenal tumor. The radiological presentation of the close ana- tomical relationship ... See full document

... Figure 2 Histological, immunohistochemical, and molecular fi ndings of E-GBM. (A) Epithelioid and rhabdoid cells were arranged in patches or were in close proximity with rich vasculature with thin walls ... See full document

... Conclusions: Gastrointestinal stromal tumor should be included in the differential diagnoses of intestinal mesenchymal tumors presenting as a single mass in young female ...that gastrointestinal ... See full document

... Management of a case of high risk gastrointestinal stromal tumor in rectum by transanal minimal invasive surgery CASE REPORT Open Access Management of a case of high risk gastrointestinal stromal tumo[.] ... See full document