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[PDF] Top 20 Impaired TLR9 responses in B cells from patients with systemic lupus erythematosus

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Impaired TLR9 responses in B cells from patients with systemic lupus erythematosus

Impaired TLR9 responses in B cells from patients with systemic lupus erythematosus

... BM cells were subjected to density gradient centrifugation to obtain mononuclear cell suspensions and remove dead ...The cells were analyzed on a Gallios flow cytometer (Beckman ...Unaltered TLR9 ... See full document

12

Expression of CXCL12 receptors in B cells from Mexican Mestizos patients with systemic lupus erythematosus

Expression of CXCL12 receptors in B cells from Mexican Mestizos patients with systemic lupus erythematosus

... of B-cell mediated autoimmune diseases including SLE ...including B cells, express CXCR4 and CXCL12 is constitutively pro- duced by stromal, epithelial, and endothelial cells notably in ... See full document

16

Active systemic lupus erythematosus is associated with a reduced cytokine production by B cells in response to TLR9 stimulation

Active systemic lupus erythematosus is associated with a reduced cytokine production by B cells in response to TLR9 stimulation

... of TLR9 stimulation on cytokine production was evaluated by analyzing the concentrations of 28 cytokines and growth factors in the supernatants of B cell cultures from healthy donors and SLE ... See full document

12

Spontaneous immunoglobulin A secretion and lack of mitogen responsive B cells in systemic lupus erythematosus

Spontaneous immunoglobulin A secretion and lack of mitogen responsive B cells in systemic lupus erythematosus

... of systemic lupus erythematosus (SLE) patients, B cell abnormalities such as a lack of mitogen-responsive B cells and a predominance of spontaneous IgA-secreting ... See full document

7

Genetic contribution to mesenchymal stem cell dysfunction in systemic lupus erythematosus

Genetic contribution to mesenchymal stem cell dysfunction in systemic lupus erythematosus

... NZM2410 lupus susceptibility locus Sle1a1, with a deletion of DNA binding exon 6 and Hox binding exon 7 ...stem cells and blocks lineage-specific differentiation ...T cells and increased ... See full document

6

Excessive activation of the TLR9/TGF β1/PDGF B pathway in the peripheral blood of patients with systemic lupus erythematosus

Excessive activation of the TLR9/TGF β1/PDGF B pathway in the peripheral blood of patients with systemic lupus erythematosus

... of TLR9, TGF-β1, or PDGF-B in the kid- neys of SLE ...that TLR9 is not expressed in normal kidneys, but TLR9 develops in podocytes in active LN patients and disappears in remis- sion ... See full document

12

Expression and clinical significance of the NEK7-NLRP3 inflammasome signaling pathway in patients with systemic lupus erythematosus

Expression and clinical significance of the NEK7-NLRP3 inflammasome signaling pathway in patients with systemic lupus erythematosus

... T cells and B cells results in the production of high levels of autoantibodies, inflamma- tory cytokines, and circulating immune complexes, as well as their invasion into tissues and organs, causing ... See full document

12

IL-22 production of effector CD4+ T-cells is altered in SLE patients

IL-22 production of effector CD4+ T-cells is altered in SLE patients

... Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown ...T-cell-dependent B-cell hyperactivity contributes to the inflammatory pathology of SLE ...and B-cells ... See full document

10

Flow cytometric assessment of the signaling status of human B lymphocytes from normal and autoimmune individuals

Flow cytometric assessment of the signaling status of human B lymphocytes from normal and autoimmune individuals

... individual cells has now made it possible to delineate the perturbations that are present in lymphocytes from patients with autoimmune ...human B cells from the Ramos B ... See full document

11

Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus

Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus

... Th17 cells in SLE, a novel finding. Because very few CD8 + T cells produced IL-17 in PBMCs from patients with SLE and healthy controls after 4 hours of PMA and ionomycin stimulation (data not ... See full document

10

Phytohemagglutinin Response in Systemic Lupus Erythematosus: RECONSTITUTION EXPERIMENTS USING HIGHLY PURIFIED LYMPHOCYTE SUBPOPULATIONS AND MONOCYTES

Phytohemagglutinin Response in Systemic Lupus Erythematosus: RECONSTITUTION EXPERIMENTS USING HIGHLY PURIFIED LYMPHOCYTE SUBPOPULATIONS AND MONOCYTES

... of cells over 0-5 days revealed a decrease in [ 3 H]TdR by stimulated lymphocytes from some SLE ...of cells in S, G 2 , and M phases of the cell ...SLE patients who were hypocomplementemic. ... See full document

14

Original Article Decreased expression of TIGIT in NK cells correlates negatively with disease activity in systemic lupus erythematosus

Original Article Decreased expression of TIGIT in NK cells correlates negatively with disease activity in systemic lupus erythematosus

... mune responses in the development of SLE [3]. Natural killer (NK) cells are a subset of mono- nuclear cells, distinguished from B and T lym- phocytes by virtue of their large granular ... See full document

11

Role of endoplasmic reticulum stress in the protective effects of PPARβ/δ activation on endothelial dysfunction induced by plasma from patients with lupus

Role of endoplasmic reticulum stress in the protective effects of PPARβ/δ activation on endothelial dysfunction induced by plasma from patients with lupus

... endothelial cells (HUVECs) incubated in plasma from patients with systemic lupus erythematosus (SLE) with active nephritis (AN) or healthy controls (Ctrol), or in plasma ... See full document

12

Immune function in systemic lupus erythematosus  Impairment of in vitro T cell proliferation and in vivo antibody response to exogenous antigen

Immune function in systemic lupus erythematosus Impairment of in vitro T cell proliferation and in vivo antibody response to exogenous antigen

... mononuclear cells from 46 systemic lupus erythematosus (SLE) patients showed reduced ability to proliferate in vitro in response to the soluble antigen, tetanus toxoid, as ... See full document

9

Enhancement of the impaired autologous mixed leukocyte reaction in patients with systemic lupus erythematosus

Enhancement of the impaired autologous mixed leukocyte reaction in patients with systemic lupus erythematosus

... and from SLE patients were fractionated into low and high density ...SLE patients were found to have an increased proportion of low density to high density non- T cells when compared to normal ... See full document

10

Immune Aging Marker Associated with Periodontitis in Systemic Lupus Erythematosus Patients

Immune Aging Marker Associated with Periodontitis in Systemic Lupus Erythematosus Patients

... Recent study, IL-2 was decreasing related to pocket, which is related to advanced periodontitis, resulting in a greater severity of the disease. Interleukine-2 is a multifunctional cytokine, considered a central ... See full document

7

Reduced number and impaired function of circulating progenitor cells in patients with systemic lupus erythematosus

Reduced number and impaired function of circulating progenitor cells in patients with systemic lupus erythematosus

... endothelial cells which, as a result of vasculitis, might have detached from the vascular ...endothelial-like cells in vitro are CD14+ and because CD14+ cells also contribute to vascular ... See full document

10

Successful use of Ustekinumab in a Patient with Psoriasis,
Psoriatic Arthritis and Systemic Lupus Erythematosus: A Case
report and Review of literature

Successful use of Ustekinumab in a Patient with Psoriasis, Psoriatic Arthritis and Systemic Lupus Erythematosus: A Case report and Review of literature

... Studies have demonstrated the role of TH-17 pathway in the pathogenesis of Systemic Lupus Erythematosus (SLE). Ustekinumab, a monoclonal antibody, binds and inhibits p40 subunit of IL-12 and 23, ... See full document

5

Mortality Patterns in Malaysian Systemic Lupus Erythematosus Patients

Mortality Patterns in Malaysian Systemic Lupus Erythematosus Patients

... Mortality Patterns in Malaysian Systemic Lupus Erythematosus Patients ORIGINAL ARTICLE Mortality Patterns in Malaysian Systemic Lupus Erythematosus Patient~ S S Yeap, MRCP*, S K Chow, MRCP*, M Manivas[.] ... See full document

5

Epratuzumab inhibits the production of the proinflammatory cytokines IL 6 and TNF α, but not the regulatory cytokine IL 10, by B cells from healthy donors and SLE patients

Epratuzumab inhibits the production of the proinflammatory cytokines IL 6 and TNF α, but not the regulatory cytokine IL 10, by B cells from healthy donors and SLE patients

... the B cell surface molecule CD22, is currently being tested in clinical trials for the treatment of SLE, and it has been shown to modu- late the activation of B ...on B cells leads to rapid ... See full document

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