[PDF] Top 20 Importance of antiresorptive therapies for patients with bone metastases from solid tumors

... Abstract: Patients with bone metastases are at risk of skeletal-related events such as pathologic fractures, spinal cord compression, the need for orthopedic surgery to bone, and palliative ... See full document

... Methods Patients and Treatments Details of the three identically designed, blinded, phase III trials comparing denosumab and zoledronic acid in patients with breast cancer ...or solid tumors ... See full document

... cancer patients with bone ...normal bone physiology as well as cancer-induced bone ...in patients with bone metastases from solid ...and bone loss in ... See full document

... of patients have bone metastases at initial diagnosis, and the incidence varies greatly in different countries or regions, which may attribute to the adoption of different prostate- specific antigen ... See full document

... brain metastases with temozolomide describe varying ...brain metastases has not yet been explored in ...brain metastases including those derived from lung (n = 91), breast (n = 72) kidney (n = ... See full document

... intracerebral metastases is characterized by a number of potential ben- efits compared with postoperative ...intracerebral metastases and surround- ing normal tissues leads to a better definition of the ... See full document

... skeletal metastases there is urgent need for inclusion of more sophisticated morphological and functional criteria, ...targeted therapies. These might include quantitative measurements of bone ... See full document

... osteoclast-mediated bone resorption, whereas the non – N-containing, fi rst-generation bisphospho- nates, such as clodronate, etidronate, and tiludronate, induce osteoclast apoptosis via metabolism into cytotoxic ... See full document

... studies, metastases in the skeleton occur at least as frequently as those in the lung ...many patients with pre- dominantly bone metastases [4], while other patients suffer from ... See full document

... in patients with advanced cancers involving bone and have become a recom- mended component of the multidisciplinary treatment of MBD ...However, bone-health benefits have not generally translated into ... See full document

... Bone metastases are common in advanced breast cancer and the 69% incidence of radiologically confirmed skeletal metastases here is in accordance with the 47-85% incidence. reported in au[r] ... See full document

... nodal metastases in thymic carcinoma and thymic neuroendo- crine tumors is lower than that reported in our ...obtained from multiple centers with- out standardization among the pathologists, and each ... See full document

... more patients with malignancies undergo whole body PET/CT, mostly to assess tumor spread in the rest of the body, but not in the ...in patients with solid extracranial ...brain metastases ... See full document

... Methods: A meta-analysis using qualified relevant literature was performed to evaluate the prognostic significance of FOXQ1 in various malignant solid tumors. A search of electronic databases was conducted ... See full document

... cancer patients: the first included only variables available on admission: age, comorbid- ity, performance status, cancer type, metastatic status, SAPS 2 and biological ... See full document

... considered patients HER2-positive if membranes of any tumor cells showed antibody staining by IHC, a threshold for HER2 positivity inconsistent with the ASCO/CAP and NCCN ...of patients from these ... See full document

... of patients with non-small- cell lung cancer or colon cancer has been correlated with the ability of the cells to spread to the lymph nodes ...in patients with colorectal carcinoma ... See full document

... and bone disease-free survival (bDFS) were defined as time from BC diagnosis to date of recurrence or death of any cause, or date of bone- specific recurrence or death of any cause, ...time ... See full document

... a bone cell activity that regulate bone remodeling, bone alkaline phosphatase (PAO), Total Intact Procollagen Type I N- terminal propeptide (TP1NP) for training and tartrate-resistant acid ... See full document

... of bone mineral density (BMD) by dual energy X-ray absorptiometry (DEXA) remains the gold standard for the diagnosis of osteoporosis and is frequently used as a primary end-point in osteoporosis treatment ... See full document