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[PDF] Top 20 The Importance of Intergenic Recombination in Norovirus GII.3 Evolution

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The Importance of Intergenic Recombination in Norovirus GII.3 Evolution

The Importance of Intergenic Recombination in Norovirus GII.3 Evolution

... gastroenteritis. Intergenic recombination between the cap- sid and RNA-dependent RNA polymerase (RdRp) genes is common and results in the acquisition of an alternative RdRp geno- ...the evolution of ... See full document

12

Recombination within the Pandemic Norovirus GII.4 Lineage

Recombination within the Pandemic Norovirus GII.4 Lineage

... novel GII.4 variants has been attributed to rapid evolution and antigenic variation in response to herd immunity; however, the contribution of recombination as a mechanism facilitating emergence is ... See full document

13

Divergent Evolution of Norovirus GII/4 by Genome Recombination from May 2006 to February 2009 in Japan

Divergent Evolution of Norovirus GII/4 by Genome Recombination from May 2006 to February 2009 in Japan

... Japan 3 ; and Sakai City Institute of Public Health, Osaka 590-0953, Japan 4 Received 7 October 2009/Accepted 29 May 2010 Norovirus GII/4 is a leading cause of acute viral gastroenteritis in ...the ... See full document

13

Evolution of norovirus

Evolution of norovirus

... the evolution of ...intragenotype recombination in NoV occur at a single location, the ORF1–ORF2 overlap [49,50], which is also the transcription start site for the viral subgenomic ...secondary ... See full document

5

Characterization of a Novel Conformational GII.4 Norovirus Epitope: Implications for Norovirus-Host Interactions

Characterization of a Novel Conformational GII.4 Norovirus Epitope: Implications for Norovirus-Host Interactions

... IMPORTANCE Human noroviruses are the main cause of viral diarrhea worldwide in people of all ages. Noroviruses can infect individuals who had been previously exposed to the same or different norovirus ... See full document

12

Molecular and evolutionary characterization of norovirus GII 17 in the northern region of Brazil

Molecular and evolutionary characterization of norovirus GII 17 in the northern region of Brazil

... NoV GII.17 strains undergo a dynamic process of evolution, and the num- ber of mutations exposed on their surface may explain amino acid changes in antigenic sites, which may be re- lated to the increase in ... See full document

11

Slow Clearance of Norovirus following Infection with Emerging Variants of Genotype GII 4 Strains

Slow Clearance of Norovirus following Infection with Emerging Variants of Genotype GII 4 Strains

... human GII.4 strains are located in a region of importance to the blocking ability of antibodies, which suggests that evasion of specific immunity is an important driving force for ...GII.4 ... See full document

7

Comparative Evolution of GII.3 and GII.4 Norovirus over a 31-Year Period

Comparative Evolution of GII.3 and GII.4 Norovirus over a 31-Year Period

... the evolution of the major capsid gene from seven archival GII.3 noroviruses collected during a cross-sectional study at the Children’s Hospital in Washington, DC, from 1975 through 1991, together ... See full document

11

The Evolution of GII.4 Norovirus and the Sources and Drivers of Norovirus Pandemics

The Evolution of GII.4 Norovirus and the Sources and Drivers of Norovirus Pandemics

... chapter 3 that node 1 most likely occurred in 2001 (Table ...chapter 3 and the Hunter 2004 common ancestor in Figure 3.1 is therefore node 3, which we inferred to occur in late 2002 (Table ...node ... See full document

257

Identification and Characterization of Antibody-Binding Epitopes on the Norovirus GII.3 Capsid

Identification and Characterization of Antibody-Binding Epitopes on the Norovirus GII.3 Capsid

... virus GII.3 infection during the 1970s or 1980s recognize the epitopes present on ...with GII.3 strains from previous ...that GII.3 an- tibody-binding epitopes are highly ... See full document

11

Emergence of a novel GII.17 norovirus – end of the GII.4 era?

Emergence of a novel GII.17 norovirus – end of the GII.4 era?

... GII.P17-GII.17 norovirus in context of current knowledge on the epidemiology of ...dominant norovirus strain ...of norovirus activity in the next seasons caused by this novel ... See full document

8

Norovirus GII.4 Strain Antigenic Variation

Norovirus GII.4 Strain Antigenic Variation

... significant evolution in the 2008 ...recognize GII.4-2008, it seems likely that much of this evolution is in response to host herd immunity and that a major new pandemic strain may be emerging in the ... See full document

12

Strain-specific interaction of a GII.10 Norovirus with HBGAs

Strain-specific interaction of a GII.10 Norovirus with HBGAs

... Discussion Increasing data suggest that NoV –HBGA interactions correlate with the host susceptibility of NoV infection and illness, making it important to determine HBGA-binding pro files of individual strains for ... See full document

9

Serological Correlates of Protection against a GII.4 Norovirus

Serological Correlates of Protection against a GII.4 Norovirus

... GI.1/ GII.4 norovirus candidate vaccine in a phase 1/2 study induced statistically significant increases in serum antibody levels (total, IgG, IgA, and HBGA blocking) to both vaccine ...from ... See full document

7

Characterization of a Novel Conformational GII.4 Norovirus Epitope: Implications for Norovirus-Host Interactions

Characterization of a Novel Conformational GII.4 Norovirus Epitope: Implications for Norovirus-Host Interactions

... KEY WORDS: Norovirus, GII.4 genotype, epitope, monoclonal antibody, virus-host 45.. interaction, viral variant, antibody escape, receptor 46.[r] ... See full document

42

Full sequence analysis and characterization of the South Korean Norovirus GII 4 variant CUK 3

Full sequence analysis and characterization of the South Korean Norovirus GII 4 variant CUK 3

... with GII-4 variants in neighboring countries, fundamental research for vaccine development, and eventually , for the field of public health through with the provision of new emerging strains of ... See full document

5

Evidence of Recombination in the Norovirus Capsid Gene

Evidence of Recombination in the Norovirus Capsid Gene

... whether norovirus evolution is driven by sequence mutation and/or ...the norovirus capsid ...of norovirus strains accessible in GenBank as well as 25 complete capsid sequences generated from ... See full document

14

Pattern of Circulation of Norovirus GII Strains during Natural Infection

Pattern of Circulation of Norovirus GII Strains during Natural Infection

... Frequency of norovirus infection and duration of RNA shed- ding in feces. Episodes of NoV infection were defined as NoV RNA-positive samples with different genotypes separated by NoV FIG 1 Phylogenetic tree of ... See full document

7

Immunogenetic mechanisms driving norovirus GII.4 antigenic variation

Immunogenetic mechanisms driving norovirus GII.4 antigenic variation

... successful norovirus vaccine regimen will require periodic population sampling to identify future strains for inclusion into the next year’s vaccine formulation not unlike the strategy employed by the Influenza ... See full document

18

Sequential Gastroenteritis Outbreaks in a Single Year Caused by Norovirus Genotypes GII.2 and GII.6 in an Institutional Setting

Sequential Gastroenteritis Outbreaks in a Single Year Caused by Norovirus Genotypes GII.2 and GII.6 in an Institutional Setting

... Background. Norovirus is a leading cause of acute gastroenteritis ...archival norovirus strains associated with gastroenteritis outbreaks that were investigated decades ... See full document

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