[PDF] Top 20 Inactivation of fatty acid transport protein 1 prevents fat induced insulin resistance in skeletal muscle
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Inactivation of fatty acid transport protein 1 prevents fat induced insulin resistance in skeletal muscle
... neomycin resistance marker under control of the phosphoglycerate kinase-promoter (PGK-neo) and a lacz gene with a nuclear localization sequence (nls-lacz) located immedi- ately downstream of the 5′ arm, thus ... See full document
9
Glucose toxicity and the development of diabetes in mice with muscle specific inactivation of GLUT4
... with muscle-specific inactivation of the GLUT4 gene (muscle GLUT4 KO) were generated and shown to develop a diabetes ...examined insulin-stimulated glucose uptake and metabolism during ... See full document
9
Coffee intake mitigated inflammation and obesity-induced insulin resistance in skeletal muscle of high-fat diet-induced obese mice
... Caffeic acid (CA) occurs in food mainly as esters known as chlorogenic acids (CGAs) (Rice-Evans et ...body fat dis- tribution and down-regulated fatty acid and cholesterol biosynthesis, but ... See full document
10
Mechanism of free fatty acid induced insulin resistance in humans
... free fatty acid levels under eu- glycemic ( z ...of muscle glycogen synthesis were similar during the first 3 h of lipid and control infu- sion, but thereafter decreased to z 50% of control values ... See full document
8
Ameliorative effects of polyunsaturated fatty acids against palmitic acid-induced insulin resistance in L6 skeletal muscle cells
... Glucose uptake in L6 myotubes was measured using an enzymatic 2DG uptake assay as previously described [23,24], with some modifications. L6 myotubes on a 96- well plate were serum-starved in 0.2% BSA/MEM for 18 h and ... See full document
9
Lipid induced insulin resistance is associated with an impaired skeletal muscle protein synthetic response to amino acid ingestion in healthy young men
... lipid-induced insulin resistance coincides with anabolic resistance is not ...of skeletal muscle protein synthesis in response to feeding, particularly in glycolytic ... See full document
19
Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial function
... saturated fatty acids Evidence has been obtained that fatty acids modulate expression of genes involved in glucose and lipid meta- ...by fatty acids, such as pyruvate dehydrogenase kinase iso- zyme ... See full document
11
The effect of N-stearoylethanolamine on cholesterol content, fatty acid composition and protein carbonylation level in rats with alimentary obesity-induced insulin resistance
... plasma insulin circulation can lead to prolonged, intense nonphysiological expression of the hepatic free cholesterol uptake transporter, low- density lipoprotein receptor and down-regulated cholesterol ... See full document
10
Athletes feature greater rates of muscle glucose transport and glycogen synthesis during lipid infusion
... of muscle glycogen ...in muscle biopsies; from steady state issues and extramuscular glucose metabolism, which affect both glucose disap- pearance rate (Rd) and glucose appearance rate (Ra) in isotopic ... See full document
13
Ablation of AMP-Activated Protein Kinase \(\alpha\)2 Activity Exacerbates Insulin Resistance Induced by High-Fat Feeding of Mice
... of skeletal muscle AMPK ␣ 2 activity exacerbates the development of glucose ...Glucose transport in isolated muscle. We next exam- ined muscle insulin sensitivity for glucose ... See full document
10
Exercise training performed simultaneously to a high-fat diet reduces the degree of insulin resistance and improves adipoR1-2/APPL1 protein levels in mice
... with insulin resistance ...enhanced insulin action on the skeletal muscle glucose transport system, reduced hormonal stimulation of hepatic glucose production, improved blood ... See full document
9
Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat induced insulin resistance
... isolated muscle, DGAT1 deficiency exacerbated insulin resistance caused by fatty acids, whereas DGAT1 overexpression mitigated the detrimental effect of fatty ...heightened ... See full document
12
Overexpression of uncoupling protein 3 in skeletal muscle protects against fat induced insulin resistance
... Insulin resistance is a major factor in the pathogenesis of type 2 diabetes and is strongly associated with ...intracellular fatty acid metabolites have been postulated to interfere with ... See full document
10
Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid–induced insulin resistance
... Muscle protein analysis. Frozen muscle samples were homogenized in ice-cold 0°C lysis buffer (50 mM HEPES, pH ...EDTA, 1% Nonidet P-40, 10% glycerol), which contained appropriate protease ... See full document
10
Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated-skeletal muscle insulin resistance
... palmitoleic acid alone generated CM that was insulin sensitising, as well as increas- ing basal glycogen synthesis, while addition of palmitoleic acid to a palmitic acid incubation is also ... See full document
14
The role of fatty acids in insulin resistance
... in protein and lower in both carbo- hydrate and fat should reduce ...generate insulin resistance in a wide variety of organs ...initiate insulin resistance via endotoxemia as ... See full document
9
Transcriptional analysis reveals a high impact of conjugated linoleic acid on stearoyl-Coenzyme A desaturase 1 mRNA expression in mice gastrocnemius muscle
... for 1 month with a cafeteria diet (a palatable, hypercaloric diet) compared with those fed with a standard-fat diet (unpublished ...not induced to this extent in C2C12 cell ... See full document
12
The effect of insulin treatment and exercise modality on skeletal muscle fiber size in streptozotocin-induced type 1 diabetic rats
... DRE resistance exercise condition but given a high proportion of MHCIIa/IIx (over 20%) and the observation of 2 distinct peaks of cross-sectional area in these hybrids (Fig ...the resistance training ... See full document
149
Effect of insulin on system A amino acid transport in human skeletal muscle
... transmembrane transport of 2-methylaminoisobutyric acid (MeAIB, a nonmetabolizable amino acid analogue, specific for system A amino acid transport) in forearm deep tissues ... See full document
9
Growth Characteristics and Lipid Metabolism of Cultured Migratory Bird Skeletal Muscle Cells
... to this subspecies. Yellow-rumped warblers are relatively small migrants with masses of ~12 grams reaching up to ~15 grams during migration. Yellow-rumped warblers are medium-distance (~2,000km) nocturnal migrants that ... See full document
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