[PDF] Top 20 Increased de novo ceramide synthesis and accumulation in failing myocardium
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Increased de novo ceramide synthesis and accumulation in failing myocardium
... the failing myocardium, and inhibition of de novo ceramide synthesis corrects abnormal ceramide content and ...SPT de novo synthesis reaction, appear ... See full document
20
Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis
... in increased liver ceramide content and ER stress, effects that were exacerbated by the combination PA plus MA, and this outcome was accompanied by lipodystrophy, enhanced liver injury, inflammation and ... See full document
18
TNF-α- and tumor-induced skeletal muscle atrophy involves sphingolipid metabolism
... markedly increased the ceramide content of L6 myotubes, consistent with a role for this sphingolipid mediator in the atrophic ...response. Ceramide accumula- tion was accompanied by a substantial ... See full document
19
Therapeutic effect and autophagy regulation of myriocin in nonalcoholic steatohepatitis
... sistance, ceramide could also inhibit FAO [23], promote triglyceride synthesis, induce hepatic lipid accumulation and lipotoxicity, induce oxidative stress, stimulate cyto- kine expression, induce ... See full document
11
SYNTHESIS OF PHYTASE DURING GERMINATION IN COTYLEDONS OF PUMPKIN SEEDS (CUCURBITA MAXIMA)
... .The experiment thus indicate that increase in phytase activity during germination requires both RNA synthesis and protein synthesis and thus involves its de novo synthesis du[r] ... See full document
6
Increased plasma membrane cholesterol in cystic fibrosis cells correlates with CFTR genotype and depends on de novo cholesterol synthesis
... that de novo cholesterol synthesis contributes sig- nificantly to the regulation of membrane ...in de novo cholesterol ...of increased NPC1 expression in CF cells perhaps in ... See full document
12
Topical effects of N-acetyl-L-hydroxyproline on ceramide synthesis and alleviation of pruritus
... AHYP affected Cer[EOP] content dose-dependently, however Cer[NS] and Cer[AP] content changes did not correspond with it. It is suggested that there are optimum AHYP concentrations for each ceramide ... See full document
7
HDAC4 controls histone methylation in response to elevated cardiac load
... in failing hearts, in agreement with a recent study on adult cardiac myocytes in which reduction of overall H3K4 levels by deletion of PAX interacting protein 1, a key component of the H3K4 complex, did not affect ... See full document
13
Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium
... are increased in hearts of patients with heart failure regardless of etiology, as well as in the hearts of ani- mals with experimental cardiac dysfunction ... See full document
11
Cardiac adenoviral S100A1 gene delivery rescues failing myocardium
... malization of S100 in failing rat hearts. Importantly, however, this normalization of myocardial S100A1 essentially restored to almost normal both the peak rate of LV pressure rise and LVESP, reflecting a rescue ... See full document
15
De Novo Initiation of RNA Synthesis by the RNA-Dependent RNA Polymerase (NS5B) of Hepatitis C Virus
... tion of recombinant systems involving the expression of indi- vidual viral gene products (6, 50). Biochemical studies of the recombinant viral proteins have identified four different virus- specific enzymatic activities. ... See full document
13
Vascular smooth muscle cell hypertrophy vs hyperplasia Autocrine transforming growth factor beta 1 expression determines growth response to angiotensin II
... on de novo protein synthesis and appears to be mediated by activation of protein kinase C ...the synthesis of latent TGF beta 1, but also promotes its conversion to the biologically active ... See full document
7
Brefeldin A Inhibits Cell-Free, De Novo Synthesis of Poliovirus
... binding and -hydrolyzing activities in the cytoplasmic HeLa extract. Accordingly, the extract was incubated in the presence of 1 mM GTPgS (a nonhydrolyzable GTP analog) at 34°C for 20 min, followed by the normal dialysis ... See full document
9
The role of gender and genetic polymorphisms in de novo choline synthesis
... postmenopausal women are resistant to developing organ dysfunction when fed a low choline diet (Fischer et al., 2007). Interestingly, within each gender category, only a subset of subjects were found to be susceptible to ... See full document
144
De Novo GMP Synthesis Is Required for Axon Guidance in Drosophila
... the de novo and salvage pathways. The de novo synthesis of guanine nucleotides involves a number of reactions that assemble the gua- nine ring from precursors, including amino acids, ... See full document
10
Accumulation of lysophosphoglycerides with arrhythmogenic properties in ischemic myocardium
... electrophysiological alterations are compatible with changes implicated in predisposing to dysrhythmia dependent on reentry, a phenomenon potentiated by the presence of zones of decreased conduction. Thus, ... See full document
9
Diminished post rest potentiation of contractile force in human dilated cardiomyopathy Functional evidence for alterations in intracellular Ca2+ handling
... tension increased after a rest interval of 120 s in the nonfailing and was unchanged in the failing myocardium ...of myocardium, and then slowly recovered to pre-rest steady state levels ... See full document
14
Combined “de novo” and “ex novo” lipid fermentation in a mix-medium of corncob acid hydrolysate and soybean oil by Trichosporon dermatis
... “de novo” and “ex novo” lipid ...“de novo” and “ex novo” lipid fermentation, sugar (such as glucose, xylose, fructose, ...“de novo” and “ex novo” lipid ... See full document
11
Regulation of Mitochondrial Function by Bioactive Sphingolipids
... [1]. Ceramide functions as an important second messenger in apoptosis signaling and is generated by de novo synthesis, sphingomyelin hydrolysis, or recycling of sphingolipids ...[dihydro] ... See full document
7
Ceramides as modulators of cellular and whole body metabolism
... sphingolipid synthesis, leading to the accumulation of ceramides and ceramide ...of ceramide accumulation is an alteration in ...These ceramide actions have important ... See full document
10
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