Top PDF Induction of Natural Killer Cell Responses by Ectromelia Virus Controls Infection
Induction of Natural Killer Cell Responses by Ectromelia Virus Controls Infection
... increased virus titers in va- ginal washings (2, ...of infection. Later in the infection (day 4), a subset of NK cells expressing the activation receptor Ly49H are specifically expanded ...hepatic ...
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Insufficient natural killer cell responses against retroviruses: how to improve NK cell killing of retrovirus infected cells
... immunodeficiency virus (SIV) or MuLV, various nucleic acid intermediates are generated (reviewed in [26]), which might be potential targets for endosomal or cyto- plasmic ...immune responses. During HIV ...
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Dose of Retroviral Infection Determines Induction of Antiviral NK Cell Responses
... ABSTRACT Natural killer (NK) cells are part of the innate immune system and rec- ognize virus-infected cells as well as tumor ...NK cell func- tionality, less is known about how the ...
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PKM2 regulation of metabolism but not transcription is important for natural killer cell responses
... post infection. Early responses to MCMV are generally cytokine mediated, resulting from increased IL-12 and IL-18 and may not be representative of NK cell cytotoxicity ...the virus was still ...
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Distinct KIR/HLA compound genotypes affect the kinetics of human antiviral natural killer cell responses
... for killer cell immunoglobulin-like receptor/HLA (KIR/HLA) compound geno- types in the outcome of viral infections, but functional data to explain these epidemiological observations have not been ...of ...
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Conferral of Enhanced Natural Killer Cell Function by KIR3DS1 in Early Human Immunodeficiency Virus Type 1 Infection
... the killer cell immunoglobulin-like receptors (KIR) in natural killer (NK) cell activity against human immunodeficiency virus type 1 (HIV-1) have yielded widely divergent ...
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Influenza Virus Directly Infects Human Natural Killer Cells and Induces Cell Apoptosis
... NK cell activity, aiming to main- tain a balance between NK cell responses and viral NK escape mechanisms, as each strives for survival (21, 31, ...NK cell immunoevasion is to allow a high ...
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Restoration of TLR3-Activated Myeloid Dendritic Cell Activity Leads to Improved Natural Killer Cell Function in Chronic Hepatitis B Virus Infection
... (CHB) infection is impaired. The underlying mechanism for the impaired NK cell function is still ...healthy controls or 39 CHB patients at baseline and during 6 months of antiviral ...NK cell ...
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Mouse Cytomegalovirus infection overrules T regulatory cell suppression on natural killer cells
... NK cell num- bers and activation in the absence of ...NK cell frequencies in uninfected DEREG mice depleted of Tregs consistent with findings reported in Scurfy mice and FoxP3 DTR knock-in mice ...upon ...
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Innate Immune Response of the Human Host to Exposure with Herpes Simplex Virus Type 1: In Vitro Control of the Virus Infection by Enhanced Natural Killer Activity via Interleukin-15 Induction
... innate responses to herpesviruses (1, 3, 33), we investigated whether in vitro infection of human peripheral blood mononuclear cells (PBMC) with HSV-1 in- creases their NK activity and whether IL-15 plays ...
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KLRG1 Negatively Regulates Natural Killer Cell Functions through the Akt Pathway in Individuals with Chronic Hepatitis C Virus Infection
... of cell surface markers and intracellular cytokine staining were performed essentially as described previously (42, ...secretion. Cell surface markers were stained with specific conjugated antibodies that ...
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Selective Loss of Natural Killer T Cells by Apoptosis following Infection with Lymphocytic Choriomeningitis Virus
... Natural killer T (NKT) cells, a unique subpopulation of T cells, coexpress markers also present on NK cells and recognize the major histocompatibility complex class I-like CD1d1 ...acute virus ...
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Cell-to-Cell Contact with Hepatitis C Virus-Infected Cells Reduces Functional Capacity of Natural Killer Cells
... of infection (MOI) of 10 and an MOI of 1, ...after infection, when NK cell responses peak in general virus infections in vivo (23), supernatant was removed from the culture wells, and ...
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Type 1 Interferon Induction of Natural Killer Cell Gamma Interferon Production for Defense during Lymphocytic Choriomeningitis Virus Infection
... ABSTRACT Natural killer (NK) cells are equipped to innately produce the cytokine gamma interferon (IFN- ␥ ) in part because they basally express high levels of the signal transducer and activator of ...
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Therapeutic Depletion of Natural Killer Cells Controls Persistent Infection
... NK cell depletion improves control of persistent LCMV ...13 infection suggested a possible role for NK cells in the maintenance of viral persistence during infection with a high dose of virus, ...
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Natural Killer Cells Are Involved in Acute Lung Immune Injury Caused by Respiratory Syncytial Virus Infection
... immune responses are required to prevent pathogen infection and to limit their spread in the ...pathogen infection and cancer and prime subsequent adaptive immune ...NK cell responses ...
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Deficient Natural Killer Dendritic Cell Responses Underlay the Induction of Theiler's Virus Induced Autoimmunity
... Viral infection is an important cofactor, along with genetic susceptibility, in the initiation of a variety of organ- specific autoimmune ...how virus infections trigger autoimmunity may lead to novel ways ...
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Natural Killer Cell Dysfunction during Acute Infection with Foot-and-Mouth Disease Virus
... Natural killer (NK) cells provide one of the initial barriers of cellular host defense against pathogens, in particular intracellular ...disease virus (FMDV) infection is ...this ...
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Hepatitis C Virus Impairs Natural Killer Cell-Mediated Augmentation of Complement Synthesis
... HCV infection, and NKG2D expression from ...Therefore, cell-to-cell contact with HCV-infected cells negatively modulates the functional capacity of NK cells, and inhibition of NK cell function ...
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In vitro infection of natural killer cells with different human immunodeficiency virus type 1 isolates.
... Viral replication was demonstrated by detection of p24 antigen intracellularly and in culture supernatants, by the presence of HIV DNA within infected cells, and by the ability of supern[r] ...
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