[PDF] Top 20 Influence of 2-dimensional organization on peptide conformation
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Influence of 2-dimensional organization on peptide conformation
... the conformation of peptides and proteins in high-molecular- density environments, and biophysical tools are today avail- able for measuring molecular conformation ...exemplar peptide and show that ... See full document
6
EFFECT OF HYDRATION AND MACROMOLECULAR CROWDING ON PEPTIDE CONFORMATION, AGGREGATION AND FOLDING KINETICS
... the conformation that a polypeptide chain assumes is dependent on the particular environment in which the folding process takes ...the conformation of a polypeptide ...the influence of geometrical ... See full document
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Arenavirus Stable Signal Peptide Is the Keystone Subunit for Glycoprotein Complex Organization
... glycoprotein complex that is not recycled within the endoplasmic reticulum but is retained as an essential subunit within purified virions (Fig. 1C). Previous studies have demonstrated a role of basic amino acids within ... See full document
14
Common DNA sequence variation influences 3 dimensional conformation of the human genome
... tin conformation across different cell types [14, 16, 21], different primary tissues [19], different cell states [22], and in response to different genetic and molecular per- turbations [23–27], producing a wealth ... See full document
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6(S) Methyl 3(S) (1 methylethyl)piperazin 2 one
... The title chiral 3,6-disubstituted piperazin-2-one, (I), was obtained during the synthesis of a potential head group mimic of the natural occurring bioactive lipid ceramide. The piperazinone skeleton has been used ... See full document
9
In vivo chromatin organization on native yeast telomeric regions is independent of a cis-telomere loopback conformation
... elements, influence several aspects of telomere functions such as telomere length regulation and tran- scriptional repression induced by telomeres, also known as Telomere Position Effect (TPE) ...chromatin ... See full document
22
Influence of oncogenic transcription factors on chromatin conformation and implications in prostate cancer
... Moreover, in the past decade, the AR signaling path- way has also been shown to play essential roles in altering chromatin conformation, primarily due to its involvement in a majority of chromosomal translocations ... See full document
11
Structural, thermal and enzymatic analysis of naturally occurring and D amino acid substituted peptides
... Approach towards selective inhibition of specific prote- ases is associated with aberrant physiology, and disease emerges as a promising therapeutic strategy. Low speci- ficity of the existing inhibitors explains the ... See full document
9
Investigating the structure of amyloid aggregates using solid state nuclear magnetic resonance
... In the last decade, solid-state NMR spectroscopists have been faced with a signifi- cant task; enable precise long-range contacts (>3 ˚ A) to be obtained on samples that are fully-labelled or, at least, have many ... See full document
228
Antecedents and outcomes of brand management from the perspective of resource based view (RBV) theory
... The conceptual model that guides the present empirical effort is presented in Figure 1. The antecedents of brand management, previously comprised of two internal organizational factors in Chen’s model -top management ... See full document
7
A folded conformation of an ascidiacyclamide derivative: 3 methoxysulfoxide (2R,3R) threoninyl desoxazoline ascidiacyclamide
... ASC conformation and symmetry of the chemical structure have been examined; additionally, we have studied the asymmetric modifications which disturb the C 2 symmetry of ASC and how this affects the ASC ... See full document
13
An investigation into the nano-/micro-architecture of electrospun poly(ε-caprolactone) and self-assembling peptide fibers
... nm) as well. However, this kind of bimodal fiber morphology resulting from the production of a net-like network of nanofibers among the larger submicron fibers has also been linked to the conductivity of the spinning ... See full document
7
Analysis of amyloid nanostructures using photo-cross-linking: in situ comparison of three widely used photo-cross-linkers
... amyloid-like peptide nanostructure as a tightly and speci fi cally packed model environment in which to photolyze the ...packed peptide environment, the data highlight technical limitations of BP and ... See full document
9
Mitotic spindle association of TACC3 requires Aurora‐A‐dependent stabilization of a cryptic α‐helix
... We have resolved why a region 30aa N-terminal to the phosphoryla- tion site is critical for TACC3 binding to Aurora-A. The region of TACC3 that is phosphorylated has low affinity for Aurora-A, and the binding affinity of ... See full document
20
FUNDAMENTAL ANALYSIS OF THREE DIMENSIONAL ‘NEAR FLING’
... This is because the fluid between the two plates is pulled by both the plates. The fluid between two plates, then, is more difficult to move than that surrounding an isolated plate, and the resulting flow causes a larger ... See full document
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The culprit behind amyloid beta peptide related neurotoxicity in Alzheimer's disease: oligomer size or conformation?
... β-sheet conformation (step I in Figure 2) and from this mixture only the β-sheet conformer can accom- modate the formation of low molecular weight, β-sheet- enriched oligomers (step II in Figure 2) ... See full document
14
Novel Aβ peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer's disease
... A hypothesis consistent with the observations in both human AD and transgenic mouse models of AD is that there are at least two, likely overlapping, stages contribut- ing to neuronal dysfunction in AD. Early events ... See full document
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Rational design and synthesis of modified teixobactin analogues: in vitro antibacterial activity against Staphylococcus aureus, Propionibacterium acnes and Pseudomonas aeruginosa
... We next evaluated the antimicrobial utility of our teixobactin analogues against the opportunistic pathogen P. acnes. The majority of the analogues showed a 2-fold higher potency against the three P. acnes strains ... See full document
14
Three-Dimensional Genome Organization and Function in Drosophila
... Indeed, PcG proteins were shown to bind to specific reg- ulatory elements of about 1000 bp. These polycomb response elements (PREs) could recruit PcG proteins also when they were inserted in transgenic constructs, where ... See full document
20
Autonomy, de facto and de jure
... that there are four possible complexes that may form between the molecule of interest and buffer. Therefore the Henry-Yoon-Kim model was then used to address the complex formation that occurred. When conjoining the Henry ... See full document
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