[PDF] Top 20 A Novel Influenza Virus Hemagglutinin-Respiratory Syncytial Virus (RSV) Fusion Protein Subunit Vaccine against Influenza and RSV

... F protein, the anti-F antibody response to other H1N1 and H3N2 viruses was ...H3N2 virus isolates in vitro but was unable to neutralize H1N1 ...one virus but not the ...reactive against the ... See full document

... that RSV and influenza share a common season- ality and that co-immunization with vaccines developed against both infectious agents is cogent from a logistics and compliance perspective, it was ... See full document

... Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections in infants ...registered vaccine available for this major ...combinant ... See full document

... pediatric respiratory pathogens RSV and ...attenuated RSV and HPIV vaccines for use in virus-naive ...attenuated RSV strains in particular are difficult to develop due to their poor ... See full document

... efficacious RSV LAV could provide vast public health benefits both from the direct prevention of RSV in vaccine recipients and from indirect herd protection of other vulnerable ...the RSV LAV ... See full document

... differentiated respiratory epithelial ...F2 subunit as the sole factor responsible for species-specific entry of RSV, whereas F1 and G do not con- ...the RSV attachment protein G in ... See full document

... Respiratory Syncytial Virus (RSV) What is Respiratory syncytial virus (RSV)? Respiratory syncytial virus (RSV) is a common virus ... See full document

... to influenza virus. Hydrophobic inter- actions between viral fusion proteins and the target membrane seem to be essential for the initiation of the fusion ...of influenza virus ... See full document

... in influenza timing, duration, and seasonal amplitude evidenced in our study are reminiscent of previous reports from Brazil, Europe and Canada showing similar patterns at smaller geographic scales ...in ... See full document

... Esterase-Fusion Protein Emi Takashita, a Yasushi Muraki, b Kanetsu Sugawara, c Hironobu Asao, d Hidekazu Nishimura, e Koji Suzuki, c,f Takashi Tsuji, f,g Seiji Hongo, c Yoshihiro Ohara, b Yoshihiro Kawaoka, ... See full document

... In previous studies, four major antigenic epitopes of influenza B virus HA, the 120-loop, the 150-loop, the 160-loop, and the 190-helix, were identified on the membrane-distal domain o[r] ... See full document

... Specimen collection Specimen collection was performed according to the method reported by Zhang et al. [26] and Tamura et al. [29]. In brief, the first immune serum samples were obtained from each mouse via tail bleeding ... See full document

... lThis alignment requires the introduction (Fig. Computer-generated graphic comparison of the deduced amino acid sequence of the influenza C/Cal/78 virus RNA 4 and the influenza B/Lee/40 [r] ... See full document

... conventional influenza vaccines, HA2 is thought to be masked by the membrane-distal portion of HA, a bulky and highly immunogenic globular head ...a vaccine which would elicit cross-reactive anti-HA2 anti- ... See full document

... at fusion pH represents one of the first atomic-resolution snapshots of putative fusion intermediates for viral envelope proteins (27, ...for fusion in influenza virus HA, it does this ... See full document

... Fusion activity was also assayed by binding and fusing RBC to the surface of CV-1 cells infected with either influenza virus (see above) or simian virus 40 (SV40)-based.. vectors contain[r] ... See full document

... perspective, vaccine produced in this way is highly purified and does not contain ovalbumin or other antigenic proteins present in eggs [11,23] ...universal influenza vaccine would be produced, it ... See full document

... F protein of RSV when CD8 1 cells are ...F protein of RSV generates a Th1-type response and virus-specific CTLs that are an abundant source of IFN- ...formalin-inactivated RSV ... See full document

... annual RSV epidemics is attributable to ...control RSV, 1 and still the mainstay of treatment for RSV infection is supplemental oxygen and ...of RSV infection, 1 has not been demonstrated ... See full document

... lower respiratory tract disease caused by RSV in certain pediatric ...the RSV season to those who would be likely to benefit from immunoprophylaxis based on certain factors, such as gestational age, ... See full document