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[PDF] Top 20 Inhibition of Lon protease by triterpenoids alters mitochondria and is associated to cell death in human cancer cells

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Inhibition of Lon protease by triterpenoids alters mitochondria and is associated to cell death in human cancer cells

Inhibition of Lon protease by triterpenoids alters mitochondria and is associated to cell death in human cancer cells

... Cancer cells produce higher levels of ROS than normal cells [25, ...in cancer progression by stimulating cell growth and genetic ...renders cells highly dependent on antioxidant ... See full document

18

Distinct effects of TRAIL on the mitochondrial network in human cancer cells and normal cells: role of plasma membrane depolarization

Distinct effects of TRAIL on the mitochondrial network in human cancer cells and normal cells: role of plasma membrane depolarization

... malignant cells and normal cells. Live-cell imaging revealed that multiple human cancer cell lines and normal cells exhibited two different modes of mitochondrial ... See full document

17

Original Article Dihydroartemisinin and cisplatinum synergistically induced apoptosis in human lung adenocarcinoma H1299 cells

Original Article Dihydroartemisinin and cisplatinum synergistically induced apoptosis in human lung adenocarcinoma H1299 cells

... of human lung adenocarcinoma is still ...using human lung adenocarcinoma H1299 cells. The cells were treated by DHA, Cis and DHA plus Cis ...Untreated cells were used as control. ... See full document

12

The oncolytic peptide LTX-315 induces cell death and DAMP release by mitochondria distortion in human melanoma cells

The oncolytic peptide LTX-315 induces cell death and DAMP release by mitochondria distortion in human melanoma cells

... lytic cell death in cancer cells, not only by directly attacking the plasma membrane, but also as a result of an injury to vital intracellular organelles, particularly mitochondria, ... See full document

14

Molecular Mechanisms of Cell Migration Inhibition by Synthetic Triterpenoids

Molecular Mechanisms of Cell Migration Inhibition by Synthetic Triterpenoids

... and cell lines. Interestingly, when cells were treated with both CDDO-Im and Cerulenin, a synergistic cytotoxic effect was observed whereby CDDO-Im treated cells could increase their sensitivity ... See full document

313

Original Article Research on mechanism of aramine for inhabitation of lung colonization of breast cancer

Original Article Research on mechanism of aramine for inhabitation of lung colonization of breast cancer

... targeting human SCN5A transcripts were con- structed according to the protocol in previous ...1.5 cell lines with similar luciferase activ- ity in vitro were ... See full document

6

Proapoptotic and antiinvasive activity of Rac1 small molecule inhibitors on malignant glioma cells

Proapoptotic and antiinvasive activity of Rac1 small molecule inhibitors on malignant glioma cells

... on human glioma cell lines LN229 and U-87 ...reduced cell proliferation, arrested cells in G1 phase, and triggered apoptosis in glioma ...affected cell migration and invasion in vitro, ... See full document

13

Botulinum neurotoxin type C protease induces apoptosis in differentiated human neuroblastoma cells

Botulinum neurotoxin type C protease induces apoptosis in differentiated human neuroblastoma cells

... developing cells of the sympathetic nervous system and are the most common form of extra-cranial solid tumour in childhood ...of cancer-related deaths in infants ...neuroblastoma cells can be ... See full document

9

Guibitang, a traditional herbal medicine, induces apoptotic death in A431 cells by regulating the activities of mitogen activated protein kinases

Guibitang, a traditional herbal medicine, induces apoptotic death in A431 cells by regulating the activities of mitogen activated protein kinases

... lung cancer, the molecular mechanisms behind these effect of GBT remain ...of cells resulting from DNA damage, mutations of functional genes, dysregulation of the cell cycle, and loss of apoptotic ... See full document

12

The Comparison Effect of Nickel (II) and Cadmium (II) Complexes with Aqueous Extract of Tecrium polium.L (Ja,adah) Plant on Hepatocellular Carcinoma Cell Line HeP2

Assist. Prof. Iman Hashim Abdulrazzaq

The Comparison Effect of Nickel (II) and Cadmium (II) Complexes with Aqueous Extract of Tecrium polium.L (Ja,adah) Plant on Hepatocellular Carcinoma Cell Line HeP2 Assist. Prof. Iman Hashim Abdulrazzaq

... growth cells of hepatocellular Carcinoma cell Line ( HeP2 ...of cancer cell line was used for determination of inhibition rate with three concentrations; ...induced death of ... See full document

8

ABCB1 and ABCC11 confer resistance to eribulin in breast cancer cell lines

ABCB1 and ABCC11 confer resistance to eribulin in breast cancer cell lines

... is associated with a poor response to chemotherapy ...breast cancer cells to anticancer agents [5, 6, 29, ...breast cancer in Japanese ...was associated with a poor prognosis in ... See full document

17

Inhibition of Aromatase and Cell Proliferation of Breast Cancer and Human Placenta Choriocarcinoma by Prunus persica Extracts

Inhibition of Aromatase and Cell Proliferation of Breast Cancer and Human Placenta Choriocarcinoma by Prunus persica Extracts

... Prunus persica has been used as a source of traditional medicine in many countries for the treatment of different diseases in females. In the present study, cytotoxicity and reactive oxygen species scavenging effects of ... See full document

8

Competency of alpha-D-glucopyranosyl Regulates Cells Death and Functions in Senescence Inhibition

Competency of alpha-D-glucopyranosyl Regulates Cells Death and Functions in Senescence Inhibition

... the cell density and as well as the number of ...revealed cells enlargement from the stage 2 to stage5 of treated rose petals , the sizes of cells were outstandingly increased compare to that of ... See full document

12

Original Article Scutellarininduces human hepatocellular carcinoma cells apoptosis through increasing autophagy

Original Article Scutellarininduces human hepatocellular carcinoma cells apoptosis through increasing autophagy

... of human hepatocellular carcinoma cell line ...the cell viability of HepG2 cells as assessed by the CCK-8 ...HepG2 cells dose-dependently, and the inhibitory effect of Scu reached to a ... See full document

10

Nelfinavir is effective against human cervical cancer cells in vivo: a potential treatment modality in resource-limited settings

Nelfinavir is effective against human cervical cancer cells in vivo: a potential treatment modality in resource-limited settings

... 10k cells were seeded directly on to the coverslip and allowed to adhere for 30 minutes at 37 ° ...The cells were incubated at 37 ° C for 24 ...the cells were washed once with PBS, then 2 mL ... See full document

10

Mitochondria: pharmacological manipulation 
of cell death

Mitochondria: pharmacological manipulation of cell death

... Cell death by apoptosis or necrosis is often important in the etiology and treatment of ...Since mitochondria play important roles in cell death pathways, these organelles are ... See full document

9

Ernst, Anne
  

(2016):


	Radiotherapy plus heat shock protein 90 inhibition: sensitizing cancer cells to irradiation-induced cell death and enhancing their immunogenicity.


Dissertation, LMU München: Medizinische Fakultät

Ernst, Anne (2016): Radiotherapy plus heat shock protein 90 inhibition: sensitizing cancer cells to irradiation-induced cell death and enhancing their immunogenicity. Dissertation, LMU München: Medizinische Fakultät

... sarcoma cell lines were performed, and quantitative scores of radioresistance were extracted by principal component ...the Cancer Genome Atlas (TCGA) database displayed upregulated expression of these ... See full document

75

Synergistic Antitumor Activity of Vitamins C and K3 on Human Bladder Cancer Cell Lines

Synergistic Antitumor Activity of Vitamins C and K3 on Human Bladder Cancer Cell Lines

... being approximately 12 - 14 months [7]. Furthermore, addition of new drugs, such as gemcitabine, to the stan- dard cisplatin-based regimens has not improved clinical outcomes [8,9]. In addition, the use of several ... See full document

13

The Different Mechanisms of Cancer Drug Resistance: A Brief Review

The Different Mechanisms of Cancer Drug Resistance: A Brief Review

... normal cells against toxic ...the cancer cells via two manners including ...with cells is the detoxification done by cytochrome ...breast cancer with increasing the activity of ... See full document

10

A caspase independent pathway mediates macrophage cell death in response to Mycobacterium tuberculosis infection

A caspase independent pathway mediates macrophage cell death in response to Mycobacterium tuberculosis infection

... serine protease- dependent macrophage cell ...THP-1 cells and human peripheral blood monocyte-derived macrophages at MOIs of 10 to 20 and assessed nuclear morphology, DNA fragmenta- tion, and ... See full document

11

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