[PDF] Top 20 Insight Into Parkinson's Disease Using Yeast as a Model to Evaluate the Role of Autophagy Genes in alpha-Synuclein Toxicity

... prion disease, Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington disease (HD), and Multiple Sclerosis ...the disease causing agent is transmitted between ... See full document

... Parkinson’s disease (PD) ...developed model organism of fission ...α synuclein expression studied was either high or low, the wild-type and A53T familial mutant of α α- α α synuclein followed ... See full document

... a role in regulating neurotransmitter vesicle pools (Jensen et ...α- synuclein leading to PD include misfolding (Winreb et ...α- Synuclein shows a gain in toxic function and expresses PD symptoms and ... See full document

... mouse model encompassing the 22q11 genomic deletion region, the Df1/+ model [108], was found to have elevated levels of α-syn and p62, a key receptor for ...causative genes in this large deletion ... See full document

... at disease risk, disease progression, or ...the disease and to predict the risk for developing the ...a disease usually display a high penetrance (> 80%), and the variability of AAOs of ... See full document

... Figure S1: A. UCSC genome browser custom tracks (genome build GRCh37/hg19, February 2009) for two SNCA triplication cases (red) and one SNCA duplication (blue). B. Illustration of comparative genomic hybridization (CGH) ... See full document

... of alpha-synuclein has not been clearly established, observations related to the protein’s cellular localization have provided clues to its ...a role for al- pha-synuclein have relied on ... See full document

... Parkinson’s disease (PD) is a fatal, incurable, neurodegenerative disease that affects approximately 4 million people ...this disease, dopaminergic neurons selectively die causing symptoms of ... See full document

... AS toxicity are mediated by changes in mitochondrial function, since AS in- hibits mitochondrial respiration and complex I activity [8, ...analysis using the fluorescent Mito- tracker reagent (Additional ... See full document

... of genes, as well as determination of the subcellular localization of their products, as it can easily be transformed with reporter constructs, ...predicted genes of which 43% have human homologs, including ... See full document

... that yeast cells that use oxidative phosphorylation for energy production show increased aSyn toxicity and aggregation (Figure 9, ...increased toxicity and aggregation is not caused merely by higher ... See full document

... Parkinson’s disease, since α-synuclein accumulation has been shown in neurons and neurites in Parkinson’ s disease postmortem brains and we found an elevation of O-GlcNAcylated proteins ... See full document

... parkinson's disease: PD is a chronic progressive degenerative disease of the Central Nervous System (CNS) that affects a region of the brain known as the "Extrapyramidal System", formed by the ... See full document

... in autophagy regulation are the MEK/ERK and the PI3K/AKT/mTOR signaling pathways [33], which are commonly deregulated in CRC [36, ...regulate autophagy in CRC. Here, we demonstrate that KRAS- induced ... See full document

... A total of 404 subjects with early PD were randomized to receive placebo, rasagiline 1 mg/day, or rasagiline 2 mg/day. Subjects had to be over age 35 with at least 2 cardinal signs of PD and disease severity of ... See full document

... the Parkinson ’ s Disease Research, Education, and Clinical Center (PADRECC), VA Greater Los Angeles Healthcare ...’ s programming expertise in the CHAPS care management tool ... See full document

... in model systems. The toxicity associated with GFP in vps34 yeast led to the analysis of another reporter gene; ...vps34 yeast, toxicity due to expression of LacZ is less than the ... See full document

... Numerous clinical studies have by now documented the presence of αSyn pathology in patients with AD, how- ever, little attention has been devoted to αSyn as a po- tential target for AD disease-modification, ... See full document

... MPTP model of PD remains unknown. In the current study, the p- α -Synuclein and p-Tau protein level, and GSK3 β activation in PD mouse model were ...mouse model of PD and proposed the possible ... See full document

... elsewhere. Using the FlexX algorithm, up to 200 poses are generated for each compound and the best pose wise and the compound with the best docking score was selected as a potent inhibitor for ... See full document