[PDF] Top 20 Insulin receptor Thr1160 phosphorylation mediates lipid induced hepatic insulin resistance
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Insulin receptor Thr1160 phosphorylation mediates lipid induced hepatic insulin resistance
... in hepatic insulin resis- tance, is caused by hepatic insulin resistance, or is unrelated to hepatic insulin resistance is actively ...dissociated hepatic ... See full document
12
Prevention of fat induced insulin resistance by salicylate
... which lipid infusion may affect muscle insulin signaling may involve increases in intracellular fatty acid derived metabolites ...5-hour lipid infusion increased muscle triglyceride and long- chain ... See full document
11
Role of resistin in diet induced hepatic insulin resistance
... Diet-induced insulin resistance is a relevant model for the most common forms of insulin resistance in ...of hepatic insulin resistance typically precedes the ... See full document
9
Hepatic CB1 receptor is required for development of diet induced steatosis, dyslipidemia, and insulin and leptin resistance in mice
... and insulin levels. Obesity induced by high-fat diets in mice is associated with changes char- acteristic of the metabolic syndrome, ...plasma lipid profile as well as elevated serum insulin ... See full document
11
L Citrulline increases hepatic sensitivity to insulin by reducing the phosphorylation of serine 1101 in insulin receptor substrate 1
... between insulin signaling and amino ...obese insulin-resistant subjects ...acid-induced insulin resistance was linked to the S6K1-mediated phosphorylation of Ser1101 in IRS-1 ... See full document
9
PKCλ in liver mediates insulin induced SREBP 1c expression and determines both hepatic lipid content and overall insulin sensitivity
... the insulin-induced increase in PI3K activity associat- ed with IRS-1 or IRS-2, respectively ...enhanced insulin-induced tyrosine phosphorylation of the insulin receptor ... See full document
11
Activation of hypothalamic S6 kinase mediates diet induced hepatic insulin resistance in rats
... Hypothalamic overexpression of CA-S6K blunts Akt phosphorylation. After 5 h of fasting, 4 μ U insulin was infused into the MBH, and 15 min later, the MBH was harvested and analyzed. MBH lysates were blotted ... See full document
11
Inhibitory effect of IL-8 on insulin action in human adipocytes via MAP kinase pathway
... of insulin resistance and increased risk for coronary heart disease ...of insulin resistance and abnormalities in lipid ...the phosphorylation of Akt by insulin [6]. ... See full document
6
Studies on the mechanism of insulin resistance in the liver from humans with noninsulin dependent diabetes Insulin action and binding in isolated hepatocytes, insulin receptor structure, and kinase activity
... controls. Insulin binding per cell number was similar in all ...However, insulin binding per surface area was decreased in the two obese groups because their hepatocytes were ...detergent-extractable ... See full document
11
A lipid-rich gestational diet predisposes offspring to nonalcoholic fatty liver disease: a potential sequence of events
... a lipid-rich diet during pregnancy shares many commonalities with that of adult NAFLD, and as illustrated in this review, it predisposes offspring for the later development of ... See full document
9
Inflammatory cytokines in type 2 diabetes mellitus as facilitators of hypercoagulation and abnormal clot formation
... IR: insulin resistance; IRS: insulin receptor substrate; JAK‑STAT : Janus kinase‑Signal Transducer and Activator of Transcription; JNK: c‑Jun N‑terminal kinase; K: clot kinetics; LDL: ... See full document
15
Tumor necrosis factor alpha and hyperglycemia induced insulin resistance Evidence for different mechanisms and different effects on insulin signaling
... of insulin secretion and by insulin resistance of the major target tissues ...particular, insulin resistance of the skeletal muscle appears to play a pivotal role in the pathogenesis of ... See full document
8
A dual role of lipasin (betatrophin) in lipid metabolism and glucose homeostasis: consensus and controversy
... The ANGPTL protein family contains 7 typical members, which are characterized by the presence of a coiled-coil domain at the N-terminus, a fibrinogen like domain at the C-terminus and a signal peptide for protein ... See full document
10
Athletes feature greater rates of muscle glucose transport and glycogen synthesis during lipid infusion
... and insulin. The insulin-mediated translocation of GLUT4 to the sarcolemmal membrane is impaired in patients with T2DM (17, 18) and results in lower intramuscular glucose and in turn lower G6P ... See full document
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ANTIDIABETIC ACTIVITY OF THE AQUEOUS EXTRACT OF ANCHUSA STRIGOSA LAB IN STREPTOZOTOCIN DIABETIC RATS
... The present study designed to evaluate the antidiabetic effect of the aqueous extract of A. strigosa in STZ-diabetic rats. STZ is toxic glucose analogue that preferentially accumulate in pancreatic β-cells via the GLUT2 ... See full document
5
Insulin Resistance in Pregnancy Is Correlated with Decreased Insulin Receptor Gene Expression in Omental Adipose: Insulin Sensitivity and Adipose Tissue Gene Expression in Normal Pregnancy
... increased insulin sensitivity because it is the rate-limiting enzyme in ...increased insulin sensitivity include other TCA and glycolytic pathway genes (Table 1), 1,4-alpha-glucan-branching enzyme 1 (GBE1) ... See full document
12
Intramyocellular lipid kinetics and insulin resistance
... in lipid oxidation such as CS (citrate synthase) and CPT1 (carni- tine palmitoylacyltransferase-1), which are often discrep- ant from actual substrate ...that lipid oxidation by skeletal muscle in obesity ... See full document
8
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... DEX induced fatty changes in the ...as insulin sensitizer through activating PPAR-ϒ and promote movement of lipids from the liver to adipose tissue ...controls lipid and glucose ...The lipid ... See full document
5
Analysis of the gene sequences of the insulin receptor and the insulin sensitive glucose transporter (GLUT 4) in patients with common type non insulin dependent diabetes mellitus
... Insulin resistance is a common feature of non-insulin-dependent diabetes mellitus (NIDDM) and "diabetes susceptibility genes" may be involved in this ...the insulin receptor ... See full document
9
Stochastic and Optimization Programming for Blood Glucose & Insulin Regulatory Systems of Type-2 Diabetes
... and lipid metabolism, and significant influences on protein and mineral ...to insulin deficiency. Non-insulin- dependent diabetes mellitus begins as a syndrome of insulin resistance in ... See full document
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