[PDF] Top 20 Insulin receptor substrate 1 is a substrate of the Pim protein kinases
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Insulin receptor substrate 1 is a substrate of the Pim protein kinases
... of Pim kinase inhibitor. Using this technique, Pim inhibitor treatment was again shown to completely prevent IGF1 stimulated phosphorylation of S1101 on human IRS1 protein (data not ...of ... See full document
14
<p>Variants in the Upstream Region of the Insulin Receptor Substrate-1 Gene Is Associated with Major Depressive Disorder in the Han Chinese Population</p>
... Insulin receptor substrate (IRS) docking proteins are the key downstream signaling molecules in the insulin receptor (IR) signaling ...that insulin can act as a growth factor in ... See full document
7
Insulin receptor substrate 1 variants in non insulin dependent diabetes
... Insulin receptor substrate-1 (IRS-1) plays an important role in insulin-stimulated signaling ...in insulin secretion capacity (estimated by insulin responses in an ... See full document
7
Hepatitis C Virus Core Protein Upregulates Serine Phosphorylation of Insulin Receptor Substrate-1 and Impairs the Downstream Akt/Protein Kinase B Signaling Pathway for Insulin Resistance
... (T2DM). Insulin resistance is a critical component of T2DM ...core protein activates c-Jun N-terminal kinase (JNK) and mitogen-activated protein kinase, we examined the contribution of these pathways ... See full document
7
A carboxy terminal truncated insulin receptor substrate 1 dominant negative protein reverses the human hepatocellular carcinoma malignant phenotype
... Insulin receptor substrate-1 (IRS-1), a substrate of various receptor tyrosine kinases transmits mitogenic signals initi- ated by extracellular ...This ... See full document
10
Modulation of insulin receptor, insulin receptor substrate 1, and phosphatidylinositol 3 kinase in liver and muscle of dexamethasone treated rats
... its receptor resulting in phosphorylation of its cytosolic substrate, insulin receptor substrate-1 (IRS-1), which in turn associates with phosphatidylinositol 3-kinase (PI ... See full document
9
Insulin receptor substrate 1 in osteoblast is indispensable for maintaining bone turnover
... or IL-11(10 ng/mL). For the determination of osteo- clastogenesis, cells were stained for TRAP as mentioned above. To determine the survival of osteoclasts, osteo- clasts formed in 8 days of the coculture were collected ... See full document
10
L Citrulline increases hepatic sensitivity to insulin by reducing the phosphorylation of serine 1101 in insulin receptor substrate 1
... Five-week-old male SPF (Specific pathogen-free) SHRSP.Z- Leprfa/IzmDmcr (SHRSP-fatty) rats were supplied by Japan SLC (Shizuoka, Japan). All rats were housed in a climate-controlled (temperature; 22 ~ 24 °C, humidity; 40 ... See full document
9
Acetylation of insulin receptor substrate-1 is permissive for tyrosine phosphorylation
... Multiple histone acetyltransferases (HATs) and histone deacetylases (HDACs) control the state of histone acetyla- tion and hence play a regulatory role in modulating the structure and function of chromatin [25]. About 20 ... See full document
14
Regulation of insulin receptor substrate 1 in liver and muscle of animal models of insulin resistance
... in insulin signal transmission based on studies with insulin receptor ...of insulin receptor and IRS-1 in liver and muscle after insulin stimulation in vivo in two rat ... See full document
12
MicroRNA-1225-5p behaves as a tumor suppressor in human glioblastoma via targeting of IRS1
... the insulin receptor substrate 1 (IRS1) was a direct functional target of miR-1225-5p in glioblastoma, and the mRNA and protein levels of IRS1 in six human glioblastoma cell lines ... See full document
12
Understanding the mechanisms of aromatase inhibitor resistance
... (insulin receptor substrate 1), SERPINA3, TFF1 and TFF3 (trefoil factors 1 and 3) and proliferation markers (CDC2, Cyclin B1, CKS2, thymidylate synthase (TYMS), proliferating cell ... See full document
11
Tumor necrosis factor alpha and hyperglycemia induced insulin resistance Evidence for different mechanisms and different effects on insulin signaling
... of insulin receptor signaling by high glucose lev- els and by TNF- a was recently observed in different cell sys- ...–induced insulin receptor inhibition and to compare the consequences of ... See full document
8
Acute Hepatic Insulin Resistance Contributes to Hyperglycemia in Rats Following Myocardial Infarction
... unknown. Insulin signaling plays a key role in the regulation of glucose ...of insulin signaling pathways could be a potential contributor to acute hyperglycemia after ...and insulin levels were ... See full document
9
Download Download PDF
... catenin, insulin (IN)/insulin-like growth factor 1 (IGF-1)/ insulin receptor substrate 1 (IRS1)/phosphatidylinositol-3-ki- nase (PI3K)/protein kinase B ... See full document
8
Insulin receptor substrate gene polymorphisms are associated with metabolic syndrome but not with its components
... with insulin resistance, salt sensitivity and non-dipper hypertension ...were 1) to investigate the insulin receptor substrate-1 (IRS-1) and insulin receptor ... See full document
7
Original Article Histone deacetylase 6 promotes insulin resistance via deacetylating phosphatase and tensin homolog (PTEN) in ovarian OVCAR-3 cells
... of insulin signaling is mediat- ed by the serine/threonine kinases Akt/PKB [27, 28] and PKC [29, 30], both of which are activated by PI3-kinase via phosphoinositide- dependent protein kinase-1 ... See full document
9
Expression and function of the insulin receptor substrate proteins in cancer
... MAPK kinases in a variety of cancer model systems ...adaptor protein [33]. Distinct intracellular compart- mentalization of IRS-1 and IRS-2 or differential sensitivi- ties of IRS-1 and IRS-2 ... See full document
15
Insulin receptor substrate signaling suppresses neonatal autophagy in the heart
... Tables 1 and 2). Transcriptional analysis in 1-day-old hearts showed preserved expression of genes involved in fatty acid oxida- tion (FAO), oxidative phosphorylation (OXPHOS), and their tran- scriptional ... See full document
16
Tyrosine kinase signalling in breast cancer: Insulin like growth factors and their receptors in breast cancer
... ‘docking protein’ for other signaling molecules ...Ras–mitogen-activated protein kinase (MAPK) cascade through Grb-2/Sos [29]; Syp phosphatase [30]; as well as other pathways involving adapters Nck and Crk ... See full document
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