[PDF] Top 20 Interferon-Regulated Pathways That Control Hepatitis B Virus Replication in Transgenic Mice

... HBeAg-matched transgenic mice (four mice per group) that were either heterozygous or homozygous for the indicated null mutation were injected intravenously with a single dose of IFN-␥ (200,000 ... See full document

... ectromelia virus and vaccinia virus as well as herpes simplex virus (HSV) by inducing nitric oxide synthase ...vaccinia virus repli- cation by inducible nitric oxide synthase occurs during ... See full document

... under control of a cytomegalovirus (CMV) ...immunodeficiency virus type 1 (HIV-1 ⌬Vif) proviral clone was previously described ...C57BL/6 mice and corresponds to the most commonly found exon ... See full document

... HBV transgenic mice before and after the adoptive transfer of HBV-specific CTLs or infection with LCMV, which inhibit HBV replication by IFN-␥- and IFN-␣/ ␤-dependent mechanisms, ...HBV ... See full document

... and replication can be inhibited by hepatocyto- tropic DNA viruses, like HBV, providing additional support to the notion that similar antiviral events can limit HBV infection during acute viral hepatitis in ... See full document

... that hepatitis C virus, a member of the Flaviviridae family, induces the upregulation of PP2Ac in vivo (liver biopsy studies of HCV transgenic mice) and in vitro (tetracycline-regulated ... See full document

... different pathways: direct re- versal, mismatch, base excision, and nucleotide-excision-medi- ated ...repair pathways other than ...repair pathways as well (reviewed in references 36, 47, and ... See full document

... The hepatitis B virus (HBV) is an enveloped DNA virus whose ...two pathways is determined by the level of envelope protein synthesis, since envelope-minus mu- tants of the duck ... See full document

... Hepatitis B virus (HBV) is a noncytopathic virus that causes a necroinflammatory liver disease characterized by a lympho- mononuclear inflammatory cell infiltrate and Kupffer cell hy- ... See full document

... HBV replication (38, ...wild-type mice receiving the same ...HBVTg mice and a strong antiviral effect. (A) Treatment scheme. (B) Representative images of liver sections stained with H&E ... See full document

... MxA transgenic mice, MxA protein is able to inhibit a broad spectrum of negative-stranded RNA viruses, including influenza virus, Thogoto virus, vesicular stomatitis virus, measles ... See full document

... To better understand the cellular processes that mediate the antiviral effect, the changes in cellular gene expression that accompany the IFN-mediated inhibition of replication in the livers of the 1.3-HBV ... See full document

... HBV replication in ...HBV replication, we first determined the expression level of the AR in the mouse liver by semiquantitative ...and replication at that ...female mice than in male ...HBV ... See full document

... Tg38 mice carried the X-null HBV ...HBV transgenic mice with ...in control mice, but it was not able to do so in Tg05 and Tg38 mice and, on the contrary, reduced the SOCS3 ... See full document

... hepadnavirus replication in infected ...HBV transgenic mice (4, 5, 11, 14) and in DHBV- and HBV-trans- fected cell lines (15, ...DHBV replication after initial conver- sion of the rcDNA of the ... See full document

... in transgenic-mouse serum was determined by two different quantitative dot blot procedures in our ...filtered transgenic-mouse serum pooled from lineages ...negative control, filtered ... See full document

... gamma interferon (IFN- g ) secretion by T and natural killer cells and to generate normal Th1 ...including hepatitis B virus ...HBV replication in the livers of transgenic ... See full document

... Reagents. Recombinant mIL-18 was kindly provided by Klaus M. Esser (Glaxo-SmithKline, Collegeville, Pa.). In all experiments, groups of three to four transgenic mice were injected subcutaneously with IL-18 ... See full document

... governing hepatitis B virus (HBV) transcription and ...be regulated by HNF4 ␣ under normal physiological conditions, it was of interest to determine the effect of fasting on the levels of HBV ... See full document

... RNA replication from a b -actin promoter in trans- genic ...additional transgenic mice which express HDV RNA from a cDNA dimer driven by a human b-actin promoter were ...this ... See full document