[PDF] Top 20 Interleukin 33 contributes to both M1 and M2 chemokine marker expression in human macrophages
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Interleukin 33 contributes to both M1 and M2 chemokine marker expression in human macrophages
... mouse macrophages [27] indepen- dent of caspase or calpain ...human macrophages. Key observa- tions from the present study included the M1 skewing effect of recombinant IL-33 on naïve ... See full document
10
Cell plasticity in wound healing: paracrine factors of M1/ M2 polarized macrophages influence the phenotypical state of dermal fibroblasts
... invading macrophages are pro-inflammatory (M1) and secrete sev- eral cytokines and chemokines, like chemokine (C-C motif ) ligand 2 (CCL2) (monocyte chemotactic protein-1), CCL7 (monocyte chemotactic ... See full document
17
Differential Effects of Alternative Glycoforms of IgG on Human Monocytes and Macrophages: Sialylated IgG Induces Novel Expression Signatures of Cell Surface Markers, Cytokines, and Chemokines
... in both T cell priming and T cell tolerance [12], and macrophages are strategically located throughout the body tissues, where they ingest and process foreign materials, dead cells and debris, and recruit ... See full document
14
TLR2 stimulation impairs anti inflammatory activity of M2 like macrophages, generating a chimeric M1/M2 phenotype
... maker expression on freshly isolated monocytes and monocyte-derived M1 and M2 macrophages from peripheral blood of HD and patients with ...generate human M1-like and ... See full document
13
Correlation analysis of monocyte subsets and insulin resistance considering fetuin-A involvement in patients with type 2 diabetes
... in both adipocytes and macrophages, signifying that FFA–fetuin-A–TLR4 ternary complex with intracellular activation of NF-κB can provoke systemic insulin resistance by enhanc- ing proinflammatory cytokine ... See full document
7
Parasitic antigens alter macrophage polarization during Schistosoma japonicum infection in mice
... the macrophages to differentiate to M1- or M2-type cells, ...marrow-derived macrophages in an in vitro induction system [30]. M1 macrophages are considered to be ... See full document
9
<p>Mimicking the Endometrial Cancer Tumor Microenvironment to Reprogram Tumor-Associated Macrophages in Disintegrable Supramolecular Gelatin Hydrogel</p>
... However, both of these two models are insuf fi cient to follow the three dimension localization of TAMs with respect to the human ...that both the three-dimensional collagen matrix and cell – cell ... See full document
13
Triggering TLR2, -3, -4, -5, and -8 Reinforces the Restrictive Nature of M1- and M2-Polarized Macrophages to HIV
... The expression level of the CD4 and CCR5 HIV receptor complex was not affected by the different treatments, and so HIV entry does not appear to be a restrictive ...of M1- and M2-polarized ... See full document
13
The macrophages in rheumatic diseases
... The primary small vessel systemic vasculitides are disorders that target small blood vessels, inducing vessel wall inflamma- tion and are associated with development of anti-neutrophil cytoplasmic antibodies (ANCAs). ... See full document
11
Macrophage Polarization in Inflammatory Diseases
... Both M1 and M2 phenotype macrophages are involved in parasite infestation, depending on the subtype and duration of parasite infestation ...general, macrophages undergo a dynamic switch ... See full document
10
Epigenetic regulation of macrophage polarization and inflammation by DNA methylation in obesity
... in macrophages suppresses inflammation and improves insulin sensitivity in cocultured 3T3-L1 ...Raw264.7 macrophages with ...the expression and secretion of TNF-α (Figure 4, ...cytokine ... See full document
21
Natural killer T cell activation increases iNOS+CD206- M1 macrophage and controls the growth of solid tumor
... NK1.1 + NKT cells comprise about 14% of the total infiltrating lymphocytes (Fig. 1a). On day 13, intratumoral NKT cells frequency was significantly reduced (Fig. 1a). Cell adhesion molecules regulate the re- cruitment of ... See full document
13
Inhibitory effects of berberine on proinflammatory M1 macrophage polarization through interfering with the interaction between TLR4 and MyD88
... of macrophages lead to local inflammation, islet β cell dysfunction and insu- lin resistance ...secretion, macrophages can be roughly divided into M1 and M2 macrophages ...the ... See full document
12
Thioredoxin peroxidase secreted by Echinococcus granulosus (sensu stricto) promotes the alternative activation of macrophages via PI3K/AKT/mTOR pathway
... PMs both in vivo and in vitro, and this induction is dependent on the antioxidant activ- ity of this enzyme, which suggests that EgTPx plays dual roles in the survival of cysts in the host by not only resist- ing ... See full document
13
Dimethyl fumarate attenuates experimental autoimmune neuritis through the nuclear factor erythroid-derived 2-related factor 2/hemoxygenase-1 pathway by altering the balance of M1/M2 macrophages
... mRNA expression levels were measured by real-time PCR using the following primers: β-actin (sense, TGG AAT CCT GTG GCA TCC ATG AAA; antisense, TAA AAC GCA GCT CAG TAA CAG TCC G); TNF-α (sense, AAC TAG TGG TGC CAG ... See full document
14
Inhibition of NOX2 reduces locomotor impairment, inflammation, and oxidative stress after spinal cord injury
... A number of NOX inhibitors have been used in the past. These include apocynin, which interferes with the assembly of the active NOX enzyme [18], and dipheny- leneiodonium (DPI), which directly blocks the catalytic ... See full document
11
Original Article Overexpression of IL-12 reverses the phenotype and function of M2 macrophages to M1 macrophages
... Interleukin-12 (IL-12), linking the innate and adaptive immune responses, belongs to the IL-12 family of cytokines. Consisting of the subunit p35 (a light chain) and p40 (a heavy chain) [9], IL-12 is mainly ... See full document
10
Chemokine Expression by Small Sputum Macrophages in COPD
... given chemokine can bind to several receptors and a given receptor can bind several ...the expression of a specific chemokine will lead, via binding to its respective receptors, to im- migration of a ... See full document
9
A nanoparticle-incorporated STING activator enhances antitumor immunity in PD-L1–insensitive models of triple-negative breast cancer
... Various immunotherapies have been advanced for clinical cancer vaccines and therapies, the most prominent are immune checkpoint blockade for solid tumors (4) and chimeric antigen receptor (CAR) T cell therapy for ... See full document
21
Macrophages migrate in an activation-dependent manner to chemokines involved in neuroinflammation
... lesions, macrophages are the dominant ...of macrophages towards the site of injury, for ex- ample, in MS lesions or ...within macrophages/ microglia in white matter MS lesions ... See full document
11
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