[PDF] Top 20 The 2.2-Kilobase Latency-Associated Transcript of Herpes Simplex Virus Type 2 Does Not Modulate Viral Replication, Reactivation, or Establishment of Latency in Transgenic Mice
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The 2.2-Kilobase Latency-Associated Transcript of Herpes Simplex Virus Type 2 Does Not Modulate Viral Replication, Reactivation, or Establishment of Latency in Transgenic Mice
... LAT transcript, as it is in the context of virus infection and ...primary transcript from the transgene is expected to overlap 1,673 bases of the ICP0 transcript, so that any elements within ... See full document
7
The Latency-Associated Transcript Gene Enhances Establishment of Herpes Simplex Virus Type 1 Latency in Rabbits
... The latency-associated transcript (LAT) gene the only herpes simplex virus type 1 (HSV-1) gene abundantly transcribed during neuronal latency, is essential for ... See full document
7
Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene Promotes Neuronal Survival
... LAT-dependent establishment function we identified in the mouse was mapped to a ...the establishment of latency is not yet ...neurons does not work on rabbit cells (81), and the validity of ... See full document
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Tissue-Specific Splicing of the Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Intron in LAT Transgenic Mice
... Transgenic mice are a useful tool to isolate the effects of individual viral proteins on viral pathogenesis in the initial absence of other viral functions ...HSV transgenic ... See full document
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The Stable 2.0-Kilobase Intron of the Herpes Simplex Virus Type 1 Latency-Associated Transcript Does Not Function as an Antisense Repressor of ICP0 in Nonneuronal Cells
... a viral transcriptional ...is associated with the polyribosome fraction of lytically and latently infected cells (20), and an open reading frame (ORF) within the ...enhances viral growth when ... See full document
15
Downstream regulatory elements increase acute and latent herpes simplex virus type 2 latency-associated transcript expression but do not influence recurrence phenotype or establishment of latency.
... After replication at a site of inoculation, herpes simplex virus (HSV) establishes latency in the sensory ganglia inner- vating that ...the virus may reactivate to cause ... See full document
7
Role of Dendritic Cells in Enhancement of Herpes Simplex Virus Type 1 Latency and Reactivation in Vaccinated Mice
... with herpes simplex virus type 1 (HSV-1) frequently leads to recurrent infection, which is a major cause of corneal ...the establishment of latency should be a primary goal of ... See full document
9
Herpes Simplex Virus Latency-Associated Transcript Sequence Downstream of the Promoter Influences Type-Specific Reactivation and Viral Neurotropism
... During latency, HSV-1 and HSV2-LAT-S1 did not re- activate ...to 2 days, similar in character to recurrences produced by HSV-2, HSV2-LAT-P1, and ...chimeric virus, which contained both the ... See full document
9
Herpes Simplex Virus 2 MicroRNA miR-H6 Is a Novel Latency-Associated Transcript-Associated MicroRNA, but Reduction of Its Expression Does Not Influence the Establishment of Viral Latency or the Recurrence Phenotype
... mutant virus had a normal recur- rence phenotype and displayed the wild-type HSV-2 pheno- type of preferential establishment of latency in KH10-positive neurons, it seems ... See full document
9
Herpes Simplex Virus type 1 lytic viral gene expression during the establishment and maintenance of latency
... DNA replication is not required for the establishment of latency per se but viral replication in the skin increases the number of virus genomes that can gain access to neurons, ... See full document
353
The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency.
... Herpes simplex virus type 1 establishes latent infections in sensory ...During latency only one locus, the latency-associated transcript (LAT), is abundantly ... See full document
9
In vivo and in vitro reactivation impairment of a herpes simplex virus type 1 latency-associated transcript variant in a rabbit eye model.
... From studies of HSV-1 LAT+ and LAT- viruses in the rabbit model using both in vitro and in vivo reactivation techniques, the data support and extend previous conclusions that i LAT expre[r] ... See full document
5
In vivo deletion analysis of the herpes simplex virus type 1 latency-associated transcript promoter.
... other viral constructs not contain- ing the region downstream of the transcription start site turn off during latency (19, ...site does not contribute apparent pro- moter activity, since in the LAT ... See full document
7
Herpes Simplex Virus Type 1 Latency-Associated Transcript Reduces Human Neuroblastoma Cell Proliferation
... any protein, it is able to change its host fate. Many investigations have revealed that it could interfere in cellular pathways. To explore the effect of LAT on neuroblastoma cells, the BE- 2(c) cells were ... See full document
8
Expression of the herpes simplex virus 1 alpha transinducing factor (VP16) does not induce reactivation of latent virus or prevent the establishment of latency in mice.
... We have previously shown 35 that the recombinant virus R314, constructed by insertion of the ot4 promoter and other sequences contained in the BamHI Z fragment of HSV-1 into the BglII si[r] ... See full document
7
Analysis of Protein Expression from within the Region Encoding the 2.0-Kilobase Latency-Associated Transcript of Herpes Simplex Virus Type 1
... Plasmid construction. The plasmid pcDNA-Pst/Mlu (55) containing the PstI- MluI restriction fragment of the HSV-1 strain F LAT gene (Fig. 1) served as the parental construct from which all other clones were derived. A ... See full document
14
The latency-associated transcript gene of herpes simplex virus type 1 (HSV-1) is required for efficient in vivo spontaneous reactivation of HSV-1 from latency.
... In both experiments, the decreased spontaneous reactivation rate of the LAT deletion mutant compared with the parental or rescued virus was statistically significant McKrae versus dLAT29[r] ... See full document
11
Selection of a nonconsensus branch point is influenced by an RNA stem-loop structure and is important to confer stability to the herpes simplex virus 2-kilobase latency-associated transcript.
... The branch RT-PCR method coupled with sequencing, de- scribed previously (58), was used to map the branch points of different mutants. The RT-PCR results are presented in Fig. 9, and the identified branch sites are ... See full document
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Novel Less-Abundant Viral MicroRNAs Encoded by Herpes Simplex Virus 2 Latency-Associated Transcript and Their Roles in Regulating ICP34.5 and ICP0 mRNAs
... less-abundant viral miRNA sequences through 454 HTP sequencing ...23-nt viral sequences (miR-I-5p, miR-II-5p, miR-II-3p, and miR-III) that were not found by manual se- quencing previously (Table ... See full document
10
Physical characterization of the herpes simplex virus latency-associated transcript in neurons.
... 1194 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest RNA transfer Northern blot analysis was used to perform the physical characterization of the transcript expressed i[r] ... See full document
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