[PDF] Top 20 FOXP3 knockdown inhibits the proliferation and reduces NOTCH1 expression of T cell acute lymphoblastic leukemia cells
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FOXP3 knockdown inhibits the proliferation and reduces NOTCH1 expression of T cell acute lymphoblastic leukemia cells
... regulatory T-cells (Tregs). Recent studies have shown that FOXP3 is associated with growth inhibition of cancer ...of FOXP3 in acute T-lymphoblastic leukemia ... See full document
5
Notch1 is required for hypoxia-induced proliferation, invasion and chemoresistance of T-cell acute lymphoblastic leukemia cells
... of T-ALL cells and the mechan- isms by which hypoxia exerts its effects are still not ...clear. Notch1 signalling has been shown to play an oncogenic role in the majority of hematological malig- ... See full document
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Original Article microRNA-204 inhibits cell proliferation in T-cell acute lymphoblastic leukemia by down-regulating SOX4
... miR-204 expression was determined in bone marrow samples from 32 leukemia patients and 32 healthy controls by quantitative real-time PCR ...on cell proliferation was evaluated by CCK8 assay, ... See full document
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Overexpression of CD59 inhibits apoptosis of T-acute lymphoblastic leukemia via AKT/Notch1 signaling pathway
... growth, proliferation, and ...the proliferation, growth and apoptosis of Jurkat ...Bax expression, IL-2 production and ...the expression of Bcl-2 and Bax in the M1 group did not change ... See full document
14
The molecular basis of T cell acute lymphoblastic leukemia
... of T-ALL is further complicated by a number of recurrent cytogenetic and molecular alterations that are common between all molecu- lar subtypes and cause deregulation in specific cellular processes, including ... See full document
9
Butein inhibits cell proliferation and induces cell cycle arrest in acute lymphoblastic leukemia via FOXO3a/p27kip1 pathway
... cellular proliferation of ALL cell lines and primary ALL blasts in a dose-dependent ...induced cell cycle arrest by decreasing the expression of cyclin E and ...the expression of ... See full document
14
Deciphering the untranslated message in T-cell acute lymphoblastic leukemia
... in T-ALL comprised mRNA and lncRNA expression profiles of T-ALL cell lines and primary T-ALL patient samples by means of deep total RNA- ...Direct NOTCH1-regulated lncRNAs were ... See full document
217
Knockdown of homeobox A5 by small hairpin RNA inhibits proliferation and enhances cytarabine chemosensitivity of acute myeloid leukemia cells
... Abnormal expression and functional changes of these genes are closely associated with tumoro- ...programmed cell death ...the expression levels of survivin, and elevated the expression levels ... See full document
6
Original Article MicroRNA-25 promotes T-cell acute lymphoblastic leukemia cell proliferation and invasion by directly targeting EphA8
... ectopic expression of miR-25 significantly promoted the proliferation, migration and invasion of T-ALL cells in ...EphA8. Knockdown of EphA8 promoted proliferation, migration and ... See full document
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Alantolactone inhibits cell autophagy and promotes apoptosis via AP2M1 in acute lymphoblastic leukemia
... NALM6 cells, whereas AP2M1 knockdown significantly reduced this pro-apoptotic effect of ...ALL cells, which was reversed by AP2M1 knockdown ...AP2M1 knockdown reverses the inhibitory ... See full document
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The NOTCH1/CD44 axis drives pathogenesis in a T cell acute lymphoblastic leukemia model
... to T-ALL pathogenesis cannot be retrospectively analyzed in patients and thus remain ill ...to cell transformation and leukemia-initiating cell (LIC) activity are promising therapeutic targets ... See full document
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Molecular And Therapeutic Implications Of Notch1 Signaling In Pediatric T-Cell Acute Lymphoblastic Leukemia
... Contemporary treatment of ALL typically lasts 2 to 2.5 years, and can be divided into 3 periods, remission induction therapy, intensification (consolidation) therapy and continuation (maintenance) therapy 20 . The goal ... See full document
172
Pediatric T-Cell Acute Lymphoblastic Leukemia
... of T-cell ALL have been known for some time, gene expression profiling and various sequencing strategies including exome and whole genome sequencing, as well as transcriptome analysis, have recently ... See full document
14
The molecular basis of T cell acute lymphoblastic leukemia
... stem cell development expressed in hematopoietic progenitors, mast cells, and erythroid and mega- karyocyte progenitors ...Abnormal expression of TAL1 is present in approximately 60% of T-ALL ... See full document
10
CAR T-cell Therapy for Acute Lymphoblastic Leukemia
... CAR T-cell therapy is currently being used as a treatment for patients who have already been treated with other therapies and ...CAR T-cell therapy trial outcomes cannot be compared to first ... See full document
9
Targeting IRAK1 in T-Cell acute lymphoblastic leukemia
... B cell lymphoma (DLBCL) [17, ...transcriptional expression of receptor and receptor-associated kinases in T-ALL by Taqman low density array (TLDA) ...of T-ALL so we sought to further explore ... See full document
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P53 mutation in acute T cell lymphoblastic leukemia is of somatic origin and is stable during establishment of T cell acute lymphoblastic leukemia cell lines
... in peripheral blood nucleated (leukemia) cells of patient H.A., that the mutation was retained by long-term T-ALL cell lines.. grown continuously for > 2 yr from H.A.'s peripheral blo[r] ... See full document
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Aberrant signaling pathways in t-cell acute lymphoblastic leukemia
... [175,176]. NOTCH1, which is mutated in half of T-ALL cases (see Section ...in T-ALL cell lines and in the intracellular NOTCH1 (ICN1)-induced mouse model, either transcriptionally, ... See full document
29
Overcoming steroid resistance in T cell acute lymphoblastic leukemia
... primary T-ALL samples at ...primary T-ALL samples ( Fig 3 ...patient-derived T-ALL xenograft [ 16 ]. Surprisingly, and in contrast with the cell line data, ruxolitinib had a synergistic effect ... See full document
6
Subset derivation of T cell acute lymphoblastic leukemia in man
... blood T cells can be characterized as belonging to either the TH+2 or TH-2 T-cell ...of T cells are TH+2, whereas 80% are TH- 2 utilizing specific ...human T-cell ... See full document
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