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[PDF] Top 20 Lack of adaptation to human tetherin in HIV 1 Group O and P

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Lack of adaptation to human tetherin in HIV 1 Group O and P

Lack of adaptation to human tetherin in HIV 1 Group O and P

... with tetherin, is predictive of anti-tetherin ...counteract tetherin, the lack of activity of the O26M chimera, which has a robust pre- sence in the TGN compartment, suggests that this is not ... See full document

18

HIV 1 Group P is unable to antagonize human tetherin by Vpu, Env or Nef

HIV 1 Group P is unable to antagonize human tetherin by Vpu, Env or Nef

... HIV-1 Group O, N and P strains are required to exclude the possibility that they may counteract the tetherin restriction through an as yet unknown ...that HIV-1 ... See full document

9

Efficient Vpu-Mediated Tetherin Antagonism by an HIV-1 Group O Strain

Efficient Vpu-Mediated Tetherin Antagonism by an HIV-1 Group O Strain

... that HIV-1 groups M and O evolved two alter- native strategies to counteract the human ortholog of the restriction factor ...While HIV-1 group M switched from Nef to Vpu ... See full document

20

Tetherin Antagonism by HIV-1 Group M Nef Proteins

Tetherin Antagonism by HIV-1 Group M Nef Proteins

... by tetherin, this activity was acquired by the Vpu protein of HIV-1 group M due to the absence of sequences in human tetherin that confer sus- ceptibility to ...that ... See full document

14

Separable Determinants of Subcellular Localization and Interaction Account for the Inability of Group O HIV-1 Vpu To Counteract Tetherin

Separable Determinants of Subcellular Localization and Interaction Account for the Inability of Group O HIV-1 Vpu To Counteract Tetherin

... by human immunodeficiency virus type 1 (HIV-1) group M strains (M-Vpu), those from the nonpandemic HIV-1 group O (O-Vpu) are not able to counteract ... See full document

12

Rapid Assay for Simultaneous Detection and Differentiation of Immunoglobulin G Antibodies to Human Immunodeficiency Virus Type 1 (HIV 1) Group M, HIV 1 Group O, and HIV 2

Rapid Assay for Simultaneous Detection and Differentiation of Immunoglobulin G Antibodies to Human Immunodeficiency Virus Type 1 (HIV 1) Group M, HIV 1 Group O, and HIV 2

... commercial HIV EIA (data not shown). Twelve HIV-1 seroconversion panels were tested to ex- amine the sensitivity of the rapid test for the detection of HIV infections during ...for ... See full document

5

The role of Vpu-mediated tetherin antagonism in HIV-1 fitness

The role of Vpu-mediated tetherin antagonism in HIV-1 fitness

... pandemic HIV-1 group M and closely related but less successful pathogens helps to expose viral vulnerabilities, which can be exploited as targets of new treatment or preventive ...distinguishes ... See full document

104

Splicing Regulatory Elements within tat Exon 2 of Human Immunodeficiency Virus Type 1 (HIV-1) Are Characteristic  of Group M but Not Group O HIV-1 Strains

Splicing Regulatory Elements within tat Exon 2 of Human Immunodeficiency Virus Type 1 (HIV-1) Are Characteristic of Group M but Not Group O HIV-1 Strains

... (group O) viruses, are more extensive, and ESS2 activity in tat exon 2 is not ...present. Group O viruses also lack the rev 3 ⴕ splice site A4b, which is conserved in all group M ... See full document

9

Identification of Amino Acids in the Human Tetherin Transmembrane Domain Responsible for HIV-1 Vpu Interaction and Susceptibility

Identification of Amino Acids in the Human Tetherin Transmembrane Domain Responsible for HIV-1 Vpu Interaction and Susceptibility

... an adaptation by HIV-1 Vpu to recognize ...of tetherin, such as B cell differentiation, the inhibition of virus production, or the regu- lation of interferon release (6, 18, 24, ... See full document

14

Vpu Mediated Counteraction of Tetherin Is a Major Determinant of HIV 1 Interferon Resistance

Vpu Mediated Counteraction of Tetherin Is a Major Determinant of HIV 1 Interferon Resistance

... which human-specific adaptations allowed HIV-1 to cause the AIDS pandemic is of great impor- ...pandemic HIV-1 group M strains from nonpandemic or rare group O, N, ... See full document

10

Cyclophilin A is required for the replication of group M human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus SIV(CPZ)GAB but not group O HIV-1 or other primate immunodeficiency viruses.

Cyclophilin A is required for the replication of group M human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus SIV(CPZ)GAB but not group O HIV-1 or other primate immunodeficiency viruses.

... this adaptation must provide a significant replication advantage for the virus in ...for HIV-1 will most likely require elucidation of the function of CyPA in HIV-1 ... See full document

8

Comparative Performance of Three Viral Load Assays on Human Immunodeficiency Virus Type 1 (HIV 1) Isolates Representing Group M (Subtypes A to G) and Group O: LCx HIV RNA Quantitative, AMPLICOR HIV 1 MONITOR Version 1 5, and Quantiplex HIV 1 RNA Version 3

Comparative Performance of Three Viral Load Assays on Human Immunodeficiency Virus Type 1 (HIV 1) Isolates Representing Group M (Subtypes A to G) and Group O: LCx HIV RNA Quantitative, AMPLICOR HIV 1 MONITOR Version 1 5, and Quantiplex HIV 1 RNA Version 3 0

... of HIV-1, it is important that commercial nucleic acid-based tests detect and quantify accurately even the most genetically divergent HIV-1 ...complete lack of detection (2, 8, 10, 18, ... See full document

9

The VP40 Protein of Marburg Virus Exhibits Impaired Budding and Increased Sensitivity to Human Tetherin following Mouse Adaptation

The VP40 Protein of Marburg Virus Exhibits Impaired Budding and Increased Sensitivity to Human Tetherin following Mouse Adaptation

... the human cell lines with restriction by, or resis- tance to, tetherin in mouse ...for tetherin in the impaired maRAVV VP40 bud- ding in human ...of HIV-1 Vpu, EBOV GP, and MARV ... See full document

11

A New World Primate Deficient in Tetherin-Mediated Restriction of Human Immunodeficiency Virus Type 1

A New World Primate Deficient in Tetherin-Mediated Restriction of Human Immunodeficiency Virus Type 1

... gray-necked group of owl monkeys and are more closely related to each other than to ...vociferans tetherin alleles and a single A. lemurinus griseimbra tetherin allele were ...griseimembra ... See full document

10

Determinants of Tetherin Antagonism in the Transmembrane Domain of the Human Immunodeficiency Virus Type 1 Vpu Protein

Determinants of Tetherin Antagonism in the Transmembrane Domain of the Human Immunodeficiency Virus Type 1 Vpu Protein

... helix, lack significant defects in tetherin ...direct tetherin-interacting surface formed upon Vpu ...targeting tetherin as a functional ...wild-type HIV-1 virion release in the ... See full document

13

The Replicative Fitness of Primary Human Immunodeficiency Virus Type 1 (HIV-1) Group M, HIV-1 Group O, and HIV-2 Isolates

The Replicative Fitness of Primary Human Immunodeficiency Virus Type 1 (HIV-1) Group M, HIV-1 Group O, and HIV-2 Isolates

... NSI/R5 HIV-1 group O isolate through phenotypic analyses (see Materials and ...diverse HIV isolates by the neighbor-joining ...several HIV reference strains and 22 HIV ... See full document

12

The Molecular Population Genetics of HIV-1 Group O

The Molecular Population Genetics of HIV-1 Group O

... HIV-1 group O originated through cross-species transmission of SIV from chimpanzees to humans and has established a relatively low prevalence in Central ...of HIV-1 group ... See full document

10

Lack of ADCC Breadth of Human Nonneutralizing Anti-HIV-1 Antibodies

Lack of ADCC Breadth of Human Nonneutralizing Anti-HIV-1 Antibodies

... different HIV-1 strains, including 2 HIV-1 reference strains ...unexpected lack of breadth of nnAbs, a phenomenon that cannot be observed in classical neutralization assays with ... See full document

19

Tetherin restricts direct cell to cell infection of HIV 1

Tetherin restricts direct cell to cell infection of HIV 1

... surface tetherin focused on cell-cell contact zones between infected and uninfected cells, as well as between uninfected cells, where it co-localized with actin (Figure ...Therefore, tetherin is adequately ... See full document

13

Confirmation of Putative HIV-1 Group P in Cameroon

Confirmation of Putative HIV-1 Group P in Cameroon

... identify group P infections; reasons may include high cross-reactivity to non-P peptides, leading to misclassification; masking of group P re- activity due to coinfection with ... See full document

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