Top PDF Lack of ADCC Breadth of Human Nonneutralizing Anti-HIV-1 Antibodies
Lack of ADCC Breadth of Human Nonneutralizing Anti-HIV-1 Antibodies
... ABSTRACT Anti-human immunodeficiency virus type 1 (HIV-1) nonneutralizing anti- bodies (nnAbs) capable of antibody-dependent cellular cytotoxicity (ADCC) have been ...
19
Importance of Fc mediated functions of anti HIV 1 broadly neutralizing antibodies
... numerous anti-HIV-1 BnAbs have been isolated and demonstrated to exhibit enhanced neutralization breadth and potency ...of HIV-1 entry [20]. Inhibition of HIV-1 ...
12
Nonneutralizing HIV-1 gp41 Envelope Cluster II Human Monoclonal Antibodies Show Polyreactivity for Binding to Phospholipids and Protein Autoantigens
... the lack of lipid reactivity of 98-6 would preclude it from engaging efficiently with a transient conformation of gp41, while it would be able to interact stably with the postfusion ...the nonneutralizing ...
8
An HIV-1 gp120 Envelope Human Monoclonal Antibody That Recognizes a C1 Conformational Epitope Mediates Potent Antibody-Dependent Cellular Cytotoxicity (ADCC) Activity and Defines a Common ADCC Epitope in Human HIV-1 Serum
... the HIV-1 Env gp120 MAb A32 binds to the surface of transmitted/founder HIV-1- infected CD4 ⫹ T cells earlier in the course of in vitro infection than the gp120 Env MAbs 17b and ...mediate ...
8
Nonneutralizing Antibodies Are Able To Inhibit Human Immunodeficiency Virus Type 1 Replication in Macrophages and Immature Dendritic Cells
... of anti- Fc␥RI, anti-Fc␥RII, or anti-Fc␥RIII (BD-Pharmingen, San Diego, ...The anti-Fc ␥ R Abs were added to cells before the addition of virus and MAb mixtures using conditions similar to ...
5
Lack of adaptation to human tetherin in HIV 1 Group O and P
... rabbit anti-Vpu antiserum (ARRRP) at a 1:1000 dilution or a rabbit anti-FLAG polycolonal antibody at a 1:500 dilution ...polyclonal anti-TGN46 antibody (Serotec, Oxford, UK) at a ...
18
Improving Neutralization Potency and Breadth by Combining Broadly Reactive HIV-1 Antibodies Targeting Major Neutralization Epitopes
... both HIV-1-infected humanized mice and SHIV-infected monkeys, have shown that MAb combinations provide a greater virologic effect than single MAbs (49, 57, ...MAbs. HIV-1-specific MAbs have ...
13
Fine Mapping of the Interaction of Neutralizing and Nonneutralizing Monoclonal Antibodies with the CD4 Binding Site of Human Immunodeficiency Virus Type 1 gp120
... MAb b12 better than or equally as well as wild-type virus, despite a decrease in b12 binding affinity for monomeric gp120, whereas mutants with very low indices are neutralized worse than wild-type virus, despite an ...
17
Heterogeneity of Envelope Molecules Expressed on Primary Human Immunodeficiency Virus Type 1 Particles as Probed by the Binding of Neutralizing and Nonneutralizing Antibodies
... immobilized antibodies (Abs) capture virus particles, have been used to suggest that nonneutralizing Abs bind effectively to human immunodeficiency virus type 1 (HIV-1) primary ...
13
Nonneutralizing Functional Antibodies: a New “Old” Paradigm for HIV Vaccines
... from HIV-1 CRF01_AE-infected blood donors, nine ADCC epitopes have been localized to the C1 and V2 region of gp120 ...mediating ADCC that can block HIV infection are directed against ...
14
Neutralisation of HIV 1 cell cell spread by human and llama antibodies
... the HIV-1 envelope protein (Env) are targeted by bNabs, however many antibodies target the conserved CD4 binding site on Env which the virus uses to bind CD4 and infect host cells ...That ...
15
Clade C HIV-1 Envelope Vaccination Regimens Differ in Their Ability To Elicit Antibodies with Moderate Neutralization Breadth against Genetically Diverse Tier 2 HIV-1 Envelope Variants
... ization breadth, in addition to standard comparative ...that antibodies that neutralize in vitro using the standard TZM-bl cell assay have consistently shown strong, titer-dependent protection when ...
22
Natural anti CCR5 antibodies in HIV infection and exposure
... in human immunology, and are currently an active field of ...the lack of somatic recombi- nation and to the poor activity of receptor editing, that increases with age ...natural antibodies are IgM ...
11
Potent and synergistic neutralization of human immunodeficiency virus (HIV) type 1 primary isolates by hyperimmune anti-HIV immunoglobulin combined with monoclonal antibodies 2F5 and 2G12.
... potent anti- HIV-1 MAbs, or HIVIG derived from multiple healthy donors, can potently neutralize many, but not all, clade B ...an HIV-1 antibody cocktail that displays a greater ...
9
Quaternary Epitope Specificities of Anti-HIV-1 Neutralizing Antibodies Generated in Rhesus Macaques Infected by the Simian/Human Immunodeficiency Virus SHIVSF162P4
... of antibodies directed against the viral surface envelope (Env) glycoprotein, ...initial anti-Env antibody response is nonneutraliz- ing (28), but within 1 or 2 months after infection, neutralizing ...
11
Broadly Neutralizing Antibodies Display Potential for Prevention of HIV-1 Infection of Mucosal Tissue Superior to That of Nonneutralizing Antibodies
... which antibodies (both nAb and nnAbs) might impact transmission ...known ADCC activity (26), while active in PBMC cultures, were ineffective in mucosal ...resident ADCC effector cells within these ...
16
Anti-HIV-1 ADCC Antibodies following Latency Reversal and Treatment Interruption
... of human immunodeficiency virus type 1 (HIV-1) cure research is to develop agents and strategies that reactivate HIV-1 from latency, induce killing of the reactivated cells, and ...
13
Human semen contains exosomes with potent anti HIV 1 activity
... 293 human embryonic kidney cell line were obtained from the American Tissue Culture Collection ...whole human blood using Ficoll-Hypaque density centrifugation according to the manufacturer’s instruction ...
16
Inhibition of Marburg Virus Budding by Nonneutralizing Antibodies to the Envelope Glycoprotein
... with anti-MARV NP rabbit serum produced by immunization with a synthetic peptide corresponding to amino acid res- idues 591 to 605 (GDILEPIRSPSSPSA) of MARV strain Angola, desig- nated FS0609, followed by a ...
8
Comparison of Heterologous Neutralizing Antibody Responses of Human Immunodeficiency Virus Type 1 (HIV-1)- and HIV-2-Infected Senegalese Patients: Distinct Patterns of Breadth and Magnitude Distinguish HIV-1 and HIV-2 Infections
... loads. HIV-1 plasma viral loads were deter- mined using a commercially available assay (Amplicor HIV-1 monitor test, version ...determine HIV-2 viral loads, an in-house real-time PCR ...
8
