[PDF] Top 20 MR Lesion Load and Cognitive Function in Patients with Relapsing Remitting Multiple Sclerosis

... between MR imaging and the physical man- ifestations of MS as evaluated through the Kurtzke Expanded Disability Status Scale (EDSS) or the Ambulation Index (AI) ...and lesion burden as reported by MR ... See full document

... of MR im- aging findings (eg, burden of disease as determined from T1- or T2-weighted MR images) with clinical outcomes (eg, Kurtzke’s Expanded Disability Sta- tus Scale scores) ...on MR imaging ... See full document

... Forty-nine patients (36 female and 13 male patients) with clinically definite relapsing-remitting multiple sclerosis accord- ing to the Poser criteria (27) were recruited for ... See full document

... The primary outcome measure was mean number of documented relapses per patient per year (mean yearly relapse rate) during weeks 0–96. This endpoint was recorded in the original protocol, but was changed in a later ... See full document

... Multiple sclerosis (MS) is a chronic autoimmune-mediated demyelinating disease of the central nervous system (CNS) that is usually associated with varying degrees of progressive ...most patients the ... See full document

... treat relapsing-remitting multiple sclerosis (RRMS) are expanding as newer, and more potent, disease-modifying treatments become ...have multiple effects on the immune system, including ... See full document

... for patients with RRMS were as follows: 1) mild-to-moderate disability (EDSS #5) to prevent the inclusion of confounding factors; 2) the absence of corticosteroid therapy or clinical relapse for at least 1 month ... See full document

... Neuronal fiber tracts are bundles with an extremely large number of axons that act as a bridge connecting the hip- pocampus to the rest of the brain. This is not unexpected, as reduced anisotropy is likely in the ... See full document

... 20 patients with cognitive impairment were recruited followed by the remaining patients without impairment and 19 HC (with no previous history of neurologic disorders) who were selected to reflect ... See full document

... MS patients with low disability those with high-fatigue show higher white and gray matter atrophy and higher lesion ...MS patients with fatigue and interferon beta-1a treatment pointed out that an ... See full document

... Forty patients, 29 women and 11 men, 20 to 62 years old, with clinically definite MS as defined by Poser criteria (24), were entered into a prospective ...28 patients were recruited from the Comprehensive ... See full document

... The role of prolactin during corticosteroid treatment The parallel time-course of prolactin and Gd-enhancing lesions during both baseline and treatment with repeated steroid infusions is intriguing with respect to a ... See full document

... contrast-enhanced MR images in patients with multiple ...spin-echo MR images obtained in 20 patients with relapsing-remitting mul- tiple sclerosis, with and without ... See full document

... for Multiple Sclerosis: Over the years the diagnostic criteria have evolved to the present revised McDonald’s criteria with greater reliance on imaging and laboratory to diagnose early ... See full document

... general, patients with ≥1 relapse per year, absence of complete recovery from relapses, sustained disability progression of ≥1 and MRI progression, with or without clinical signs, are considered as ‘treatment ... See full document

... By studying a single subject longitudinally, potential data variability and confounding factors such as gender, comorbid conditions, and genetics were removed. With the exception of a single neurosurgical procedure to ... See full document

... of patients with MS in treatment, reducing discomfort and inconvenience and making it easier for patients to adhere to their treatment regimen, thus improving ... See full document

... Female BALB/c mice were injected intraperitoneally with either 0.5 ml pristane (Sigma-Aldrich) or PBS at 7 weeks of age. The medications were administered daily by oral gavage from the starting day until the experi- ... See full document

... DNA hypomethylation at CpGs was distributed at a sur- rounding of transcriptional start sites, while hypermethy- lated CpGs were mainly located in the main body of genes. Among the hypermethylated autosomal genes, ... See full document

... for patients to prevent or abrogate ongoing joint ...eRA patients (n = 34) using the Alu115 and b-actin205 primer sets and performed additional analyses with mate- rial from healthy controls (n = ...esRA ... See full document