[PDF] Top 20 Limited HIV 1 Superinfection in Seroconverters from the CAPRISA 004 Microbicide Trial
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Limited HIV 1 Superinfection in Seroconverters from the CAPRISA 004 Microbicide Trial
... for superinfection, and they were distinctly different in terms of rates of primary infections and ...the CAPRISA 004 trial ...which limited its ability to identify more subtle ... See full document
5
One Percent Tenofovir Applied Topically to Humanized BLT Mice and Used According to the CAPRISA 004 Experimental Design Demonstrates Partial Protection from Vaginal HIV Infection, Validating the BLT Model for Evaluation of New Microbicide Candidates
... a 1% tenofovir gel twice within a 24-h period, once before and once after sex ...vaginal HIV transmission, and self- reported “high adherers” ( ⬎ 80%) experienced a 54% reduc- tion in incidence of ... See full document
12
Recruitment of high risk women for HIV prevention trials: baseline HIV prevalence and sexual behavior in the CAPRISA 004 tenofovir gel trial
... the CAPRISA 004 trial results with young rural FP women with low coital frequency but social instability resulting from partner’s being migrant workers on one hand and on the other hand, the ... See full document
8
Intravaginal practices and microbicide acceptability in Papua New Guinea: implications for HIV prevention in a moderate prevalence setting
... of HIV, consti- tuting over 50% of all those living with HIV worldwide and nearly 60% in sub-Saharan Africa ...affordable HIV prevention methods that are initiated and controlled by women have ... See full document
14
Dynamics of Viral Evolution and Neutralizing Antibody Response after HIV-1 Superinfection
... the HIV-1 Env quasispecies derived as a population from the patient plasma, so for the neutralization assays a representative sampling of all of the Env variants present in the subject’s plasma were ... See full document
8
Performance of a Rapid and Simple HIV Testing Algorithm in a Multicenter Phase III Microbicide Clinical Trial
... Determine HIV-1/2 test, with a much higher rate ...Determine HIV-1/2 assay with specimens from Uganda has been reported previously (6, 12, ...Determine HIV-1/2 test (12). ... See full document
6
HIV 1 sequence evolution in vivo after superinfection with three viral strains
... of HIV-1 are involved, but as recombination is typical in HIV replication, recombinant viruses are present in any infected ...of HIV-1 as governed by the viral RT is supposed to be more ... See full document
14
Disease progression of HIV-1 infection in symptomatic and asymptomatic seroconverters in Osaka, Japan: a retrospective observational study
... excluded from a history of ...for HIV infection were assigned to the symptomatic recent group, and those who did not were assigned to the asymptomatic recent ...plasma HIV-1 RNA level was ... See full document
8
Intravaginal rings as delivery systems for microbicides and multipurpose prevention technologies
... of microbicide (and MPT) IVRs includes a focus on the effect of the IVR on the subclinical and physical properties of the vaginal mucosa, as well as any systemic ...of HIV-1, likely through frank ... See full document
14
An Equine Infectious Anemia Virus Variant Superinfects Cells through Novel Receptor Interactions
... EIAV infection and replication were assessed by immunostaining infected cell populations for viral antigens as previously described (14). Virus titers were determined on ED cells by serial dilution of stocks followed by ... See full document
8
Latent HIV-1 Can Be Reactivated by Cellular Superinfection in a Tat-Dependent Manner, Which Can Lead to the Emergence of Multidrug-Resistant Recombinant Viruses
... ongoing HIV-1 replication during suppressive HAART (83, 84), the general consensus is that ongoing replication does not occur in most HAART-treated patients ...arises from reactivation of latent ... See full document
13
A Caulobacter crescentus Microbicide Protects from Vaginal Infection with HIV-1JR-CSF in Humanized Bone Marrow-Liver-Thymus Mice
... ender V, Mgodi NM, Matovu Kiweewa F, Nair G, Mhlanga F, Siva S, Bekker LG, Jeenarain N, Gaffoor Z, Martinson F, Makanani B, Pather A, Naidoo L, Husnik M, Richardson BA, Parikh UM, Mellors JW, Marzinke MA, Hendrix CW, van ... See full document
16
Inactivation of HIV 1 in breast milk by treatment with the alkyl sulfate microbicide sodium dodecyl sulfate (SDS)
... of HIV-1 is pre- ventable with highly active antiretroviral therapy com- bined with total avoidance of ...the HIV/AIDS ...of HIV-1 through breast milk are in demand to act in synergy ... See full document
10
Analysis of infectious virus clones from two HIV 1 superinfection cases suggests that the primary strains have lower fitness
... of HIV-1 superinfection in vivo is relatively new ...productive superinfection have increased fitness over the primary infecting strain (see [13,14] and references ...described ... See full document
15
Restriction of V3 region sequence divergence in the HIV 1 envelope gene during antiretroviral treatment in a cohort of recent seroconverters
... in HIV population diver- sity are apparent at primary infection and here we arbi- trarily assigned individuals into 3 diversity groups (low, medium and high) based on Shannon ...of HIV sequence diversity ... See full document
15
In Vitro Reactivation of Replication-Competent and Infectious HIV-1 by Histone Deacetylase Inhibitors
... long-lived HIV-1-infected resting memory CD4 T cells is thought to be the primary obstacle to HIV-1 eradica- ...reverse HIV-1 latency, inhibitors of histone deacetylases (HDACis) ... See full document
14
Punica granatum(Pomegranate) juice provides an HIV 1 entry inhibitor and candidate topical microbicide
... kit from Promega (Madison, WI) in an Ultra 384 luminometer (Tecan, Research Triangle Park, ...for 1 h at 37°C. The wells were washed 5 × with TS. Biotinyl-CD4 (1 µg/ml) in TS-1% gelatin was ... See full document
12
Application and removal of polyanionic microbicide compounds enhances subsequent infection by HIV 1
... The present results, as well as the results of previously published studies, indicate that enhancement under these conditions is also dependent on the identity of the compound. This same assay design was previously used ... See full document
13
Assessment of Ambiguous Base Calls in HIV 1 pol Population Sequences as a Biomarker for Identification of Recent Infections in HIV 1 Incidence Studies
... of HIV-1 genotyping, including RNA extrac- tion, cDNA synthesis, PCR, sequencing, and sequence ...different HIV-1 subtypes, can introduce a bias to specific virus ...of seroconverters ... See full document
7
Intrasubtype B HIV-1 Superinfection Correlates with Delayed Neutralizing Antibody Response
... Neutralization susceptibility of superinfecting viral strains. To test the neutral- ization susceptibility of the superinfecting virus, two env clones were selected that represented the superinfecting viral lineage (Fig. ... See full document
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