[PDF] Top 20 A long noncoding RNA mediates both activation and repression of immune response genes
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A long noncoding RNA mediates both activation and repression of immune response genes
... innate immune system coordinates host defenses through germ line–encoded pat- tern recognition receptors ...of long noncoding RNAs (lncRNAs) in mammalian genomes (4–9) that regulate gene expression ... See full document
5
Human Papillomavirus 16 E6 and E7 Synergistically Repress Innate Immune Gene Transcription
... This activation promotes recruitment of homologous recombination factors to the viral genome, a process required for HPV16 replication ...The activation of the DDR by external DNA-damaging agents results in ... See full document
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Unique Signatures of Long Noncoding RNA Expression in Response to Virus Infection and Altered Innate Immune Signaling
... of long noncoding RNAs ( ⬎ 200 nt) were compiled from UCSC known genes and three published studies (7, 10, ...using RNA-Seq for protein-coding loci (19), as the gene structures of many ncRNAs ... See full document
9
Identification of lncRNA expression profiles and ceRNA analysis in the spinal cord of morphine-tolerant rats
... that long noncoding RNAs (lncRNAs) might be a novel and promising target in the pathogeneses of ...of Genes and Genomes (GO/KEGG), and predictions for the differentially expressed lncRNAs (DElncRNAs) ... See full document
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Long Noncoding RNA: Recent Updates in Atherosclerosis
... bind both PRC1 and PRC2 to repress its targets ...target genes by acting as a decoy to sequester regulatory factors, ...its repression on Phb2 ...gene activation. Jpx knocking-down inhibits ... See full document
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Long noncoding RNA EWSAT1 mediated gene repression facilitates Ewing sarcoma oncogenesis
... of genes repressed by EWS-FLI1 (8, 16). Direct activation of gene expression by EWS-FLI1 occurs via binding to a consensus motif near promoters or by binding to a distal microsatellite repeat (57, ... See full document
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A novel long noncoding RNA HOXC AS3 mediates tumorigenesis of gastric cancer by binding to YBX1
... regulatory genes, which likely play pivotal roles in gene interactions and regula- tion ...cancer genes, such as p21, FAS, CCND1, and CDK2; real-time PCR con- firmed these genes after knockdown of ... See full document
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Long noncoding RNA expression profiles in sub lethal heat treated hepatoma carcinoma cells
... Long noncoding RNA (lncRNA) is generally defined as a transcript larger than 200 nucleotides that lacks protein-coding ...imprinting, immune response, tumori- genesis, cellular ... See full document
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Long noncoding RNA Malat1 regulates differential activation of macrophages and response to lung injury
... Myeloid ablation of Malat1 promotes bleomycin-induced pulmonary fibrosis. We had shown that Malat1 inhibited the profibrotic macrophage phenotype induced by BALFs from lungs of bleomycin-treated mice in vitro. We also ... See full document
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Long Noncoding RNA ITPRIP-1 Positively Regulates the Innate Immune Response through Promotion of Oligomerization and Activation of MDA5
... that long noncoding RNAs (lncRNAs) regulate various biological processes, especially innate and adaptive ...of both the full length and the 2 caspase activation and recruitment domains of MDA5 ... See full document
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CRISPR Interference of a Clonally Variant GC Rich Noncoding RNA Family Leads to General Repression of var Genes in Plasmodium falciparum
... the activation mechanism of the uniquely expressed var member re- mains ...GC-rich noncoding RNA (ncRNA) gene family has coevolved with Plasmodium species that express var ...transcriptional ... See full document
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Double-stranded RNA innate immune response activation from long-term adeno-associated virus vector transduction
... Adeno-associated virus (AAV) vectors encoding factor IX (FIX) have been successfully applied in clini- cal trials in patients with hemophilia B (1–4). Following AAV-FIX administration, transgene-derived FIX serum levels, ... See full document
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Infiltration-RNAseq: transcriptome profiling of Agrobacterium-mediated infiltration of transcription factors to discover gene function and expression networks in plants
... of genes involved in anthocyanin biosynthe- sis and regulation in ...in genes normally only found in seeds, such as seed storage proteins (legumin, globulin, glutelin) and lipid binding or storage proteins ... See full document
13
Regulation of DNA Double-Strand Break Repair by
... Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in. 780[r] ... See full document
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Prognostic significance of the long noncoding RNAs in nasopharyngeal carcinoma: a systematic review and meta-analysis
... silences genes via interaction with PRC2 and LSD1, and aids protein degradation via interaction with E3 ubiquitin ligases; the knockdown of HOTAIR reduces tumor invasive- ness and disrupts epithelial mesenchymal ... See full document
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<p>Association Between lncRNA HULC rs7763881 Polymorphism and Gastric Cancer Risk</p>
... antisense RNA; HULC, highly upregulated in liver cancer; HWE, Hardy Weinberg equilibrium; LncRNAs, long non-coding RNAs; LNM, lymph node metastasis; MALAT1, metastasis-associated lung adeno- carcinoma ... See full document
6
Dectin 1 Is Expressed in Human Lung and Mediates the Proinflammatory Immune Response to Nontypeable Haemophilus influenzae
... To confirm the regulatory function of Dectin-1 during the in- fection of the NHBE cell monolayer by NTHI, we performed “gain-of-function experiments” by transfecting a Dectin-1- expressing vector in Dectin-1-negative ... See full document
9
Expressions of Long Non Coding RNAs in Carcinogenesis of Cervix: A Review
... Growth arrest-specific transcript 5 (GAS5) lncRNA has many small nucleolar RNAs (snoRNAs), microRNAs (miRNAs) and PIWI-interacting RNAs (piR- NAs) located in the 1q25 chromosomal region which was initially extracted from ... See full document
16
Multiplicity in Long Noncoding RNA in Living Cells
... short-lived long non-coding RNAs as surrogate indicators for chemical ...and long noncoding RNAs ...types. Long noncoding RNA s are an important class of pervasive ... See full document
6
The multidimensional mechanisms of long noncoding RNA function
... lncRNAs as modulators of proteins and enzyme cofactors In most of the known examples, the detailed mecha- nisms by which lncRNAs enhance or inhibit the activity of proteins is not completely understood, but are prob- ... See full document
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