Reactivation of PAX2 has been frequently observed in clear cell renal cell carcinoma (ccRCC), a tumor type characterized by loss of von Hippel-Lindau (VHL) tumor suppressor

Regulation of VCAM-1 levels through a VHL-PHD-NF κ B-dependent pathway and its role in the immune response against clear-cell renal cell carcinoma.. VHL loss, hypoxia and

We report that in hepatocellular carcinoma and clear cell renal carcinoma cells, increased activity of hypoxia-inducible factors (HIFs) due to hypoxia or VHL

RCC: renal cell carcinoma; ccRCC: clear cell renal cell carcinoma; mRCC: meta- static renal cell carcinoma; VHL: von Hippel–Lindau; HIFs: hypoxia-inducible factors; EGF:

In clear cell renal cell carcinoma (ccRCC), loss of von Hippel-Lindau tumour suppressor ( VHL ), seen in 90% of ccRCCs, leads to the stabilization of hypoxia inducible

Clear cell renal cell carcinoma (ccRCC) is characterized by loss of the tumor suppressor von Hippel-Lindau ( VHL ) and altered cancer cell metabolism.. Here, we assessed how

Extensive work in the grounds has been undertaken and there are lovely mature trees, an attractive Victorian grass tennis court and walled garden, together with river frontage..

BM: Bone metastases; ccRCC: Clear cell renal cell carcinoma; HIF1- α : Hypoxia-inducible factor 1-alpha; mRCC: Metastatic renal cell carcinoma; mTOR: Mammalian target of

A simple fluorescence endomicroscope can be constructed using a fiber bundle, camera, LED and filters, and individual images can be mosaicked as the probe is moved across the

|| Grade 1 and 2 were combined and used as reference in univariate and multivariate analysis. Grade was encoded as an ordinal variable with

We have found that VHL-deficient human renal carcinoma cells have reduced protein and mRNA expression of key HR and MMR genes down-regulated by hypoxia, including

Real-time quantitative PCR results showed that TET1 mRNA levels were significantly lower in RCC than matched adjacent benign tissues, while TET2 expression did not differ between

Recently, a study has demonstrated elegantly that HIF  effects on c-myc could distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma :

Renal-cell carcinomas, Chronic renal failure, End-stage renal disease (ESRD), Hypoxia- inducible factor a (HIFa), Hippel–Lindau tumor suppressor (VHL)

although our goal was to identify a new HIF2α inhibitor, we characterized the expression status of both HIF1α and HIF2α in 15 VHL-deficient clear cell kidney cancer cell lines and

Low CAIX expression and absence of VHL gene mutation are associated with tumor aggressiveness and poor survival of clear cell renal cell carcinoma.. Rioux-Leclercq N, Fergelot

Clear cell carcinoma 70-75% Papillary renal cell carcinoma 10-15% Chromophobe renal cell carcinoma 3-5% Oncocytoma 3-5% Others 1%. Clear cell

Figure 3.2 MYC activation combined with Vhl and Ink4a/Arf loss results in histopathological changes in the kidney resembling human clear cell renal carcinomas