18 results with keyword: 'loss vhl hypoxia provokes regulation clear renal carcinoma'
Reactivation of PAX2 has been frequently observed in clear cell renal cell carcinoma (ccRCC), a tumor type characterized by loss of von Hippel-Lindau (VHL) tumor suppressor
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Regulation of VCAM-1 levels through a VHL-PHD-NF κ B-dependent pathway and its role in the immune response against clear-cell renal cell carcinoma.. VHL loss, hypoxia and
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We report that in hepatocellular carcinoma and clear cell renal carcinoma cells, increased activity of hypoxia-inducible factors (HIFs) due to hypoxia or VHL
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RCC: renal cell carcinoma; ccRCC: clear cell renal cell carcinoma; mRCC: meta- static renal cell carcinoma; VHL: von Hippel–Lindau; HIFs: hypoxia-inducible factors; EGF:
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In clear cell renal cell carcinoma (ccRCC), loss of von Hippel-Lindau tumour suppressor ( VHL ), seen in 90% of ccRCCs, leads to the stabilization of hypoxia inducible
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Clear cell renal cell carcinoma (ccRCC) is characterized by loss of the tumor suppressor von Hippel-Lindau ( VHL ) and altered cancer cell metabolism.. Here, we assessed how
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Extensive work in the grounds has been undertaken and there are lovely mature trees, an attractive Victorian grass tennis court and walled garden, together with river frontage..
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BM: Bone metastases; ccRCC: Clear cell renal cell carcinoma; HIF1- α : Hypoxia-inducible factor 1-alpha; mRCC: Metastatic renal cell carcinoma; mTOR: Mammalian target of
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A simple fluorescence endomicroscope can be constructed using a fiber bundle, camera, LED and filters, and individual images can be mosaicked as the probe is moved across the
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|| Grade 1 and 2 were combined and used as reference in univariate and multivariate analysis. Grade was encoded as an ordinal variable with
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We have found that VHL-deficient human renal carcinoma cells have reduced protein and mRNA expression of key HR and MMR genes down-regulated by hypoxia, including
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Real-time quantitative PCR results showed that TET1 mRNA levels were significantly lower in RCC than matched adjacent benign tissues, while TET2 expression did not differ between
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Recently, a study has demonstrated elegantly that HIF effects on c-myc could distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma :
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Renal-cell carcinomas, Chronic renal failure, End-stage renal disease (ESRD), Hypoxia- inducible factor a (HIFa), Hippel–Lindau tumor suppressor (VHL)
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although our goal was to identify a new HIF2α inhibitor, we characterized the expression status of both HIF1α and HIF2α in 15 VHL-deficient clear cell kidney cancer cell lines and
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Low CAIX expression and absence of VHL gene mutation are associated with tumor aggressiveness and poor survival of clear cell renal cell carcinoma.. Rioux-Leclercq N, Fergelot
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Clear cell carcinoma 70-75% Papillary renal cell carcinoma 10-15% Chromophobe renal cell carcinoma 3-5% Oncocytoma 3-5% Others 1%. Clear cell
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