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[PDF] Top 20 Malaria in South America: a drug discovery perspective

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Malaria in South America: a drug discovery perspective

Malaria in South America: a drug discovery perspective

... Results Natural products Pharmacognosy is the study of naturally occurring mole- cules with medicinal properties. Plant-derived com- pounds have been the backbone of the anti-malarial class of drugs over the last ... See full document

12

Malaria vectors in South America: current and future scenarios

Malaria vectors in South America: current and future scenarios

... of malaria vector species were associated with that of ...2070 South America, with the distribution of the pathogen covering 35-46 % of the ...of malaria transmission in South ... See full document

13

New Antimalarial drug discovery in India and Future strategy for malaria control

New Antimalarial drug discovery in India and Future strategy for malaria control

... WHO-Global Malaria Programme (21 st May, 2014) Emergence and spread of artemisinin resistance calls for intensified efforts to withdraw oral artemisinin- based monotherapy from the ...antimalarial drug. ... See full document

22

Drug resistance in malaria

Drug resistance in malaria

... the discovery of the first case of chloroquine resistance along the Thai-Combodian border in the late 1950s, Southeast Asia has played an important role as a focus for the development of drug resistance in ... See full document

9

The Impact of Whole Genome Sequence Data on Drug Discovery—A Malaria Case Study

The Impact of Whole Genome Sequence Data on Drug Discovery—A Malaria Case Study

... family perspective can influence tar- get discovery and inhibitor ...lel drug discovery programs where a family of targets is considered, rather than serial programs built on a single ... See full document

13

Discovery: an interactive resource for the rational selection and comparison of putative drug target proteins in malaria

Discovery: an interactive resource for the rational selection and comparison of putative drug target proteins in malaria

... When approaching the search from the ligand perspective, the user may search by ligand keyword, or by drawing a chemical structure using the Marvin applet. Different methods are then available to search with the ... See full document

8

Open source drug discovery with the Malaria Box Compound collection for neglected diseases and beyond

Open source drug discovery with the Malaria Box Compound collection for neglected diseases and beyond

... of America, 6 Departments of Physiology & Biophysics, Neuroscience and Medicine, Albert Einstein College of Medicine, New York, New York, United States of America, 7 Dipartimento Malattie Infettive, ... See full document

23

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

... for Malaria Research, Pennsylvania State University, University Park, Pennsylvania, United States of America, 29 School of Life and Environmental Sciences, University of Sydney, Darlington New South ... See full document

23

Application of multi-target phytotherapeutic concept in malaria drug discovery: a systems biology approach in biomarker identification

Application of multi-target phytotherapeutic concept in malaria drug discovery: a systems biology approach in biomarker identification

... prominent discovery of some vital ...antimalarial drug is atovaquone, a synthetic naphthoquinone based on lapachol, a prenylnaphtoquinone, first isolated from Tabebuia impetiginosa, a South American ... See full document

16

Quinazolinone derivatives as a potential class of compounds in malaria drug discovery

Quinazolinone derivatives as a potential class of compounds in malaria drug discovery

... Potential Drug Targets for Antimalarial Drugs With the technological developments of the past few decades, the ability to search for new drug candidates has rapidly ...novel drug targets and design ... See full document

27

A perspective on multi target drug discovery and design for complex diseases

A perspective on multi target drug discovery and design for complex diseases

... to drug design in recent years, building on the molecular structure deter- minations of previous decades (a process still ongoing for membrane proteins such as ... See full document

14

IP Strategy for Drug Discovery: A Dedicated Research Firm s Perspective

IP Strategy for Drug Discovery: A Dedicated Research Firm s Perspective

... The timing of filing a patent is another important aspect that needs to be taken care of. Typically it would take 7 to 8 years for any drug to hit the market, from the time it enters clinical trials. Hence, the ... See full document

6

ADDME – Avoiding Drug Development Mistakes Early: central nervous system drug discovery perspective

ADDME – Avoiding Drug Development Mistakes Early: central nervous system drug discovery perspective

... of drug transporters on permeability and the effect of drugs on transporter activity can be measured in Caco-2 for the impact on intestinal absorption or using relevant in vitro BBB ...of discovery, but ... See full document

11

When fragments link : a bibliometric perspective on the development of fragment-based drug discovery

When fragments link : a bibliometric perspective on the development of fragment-based drug discovery

... With academia laying out FBDD’s foundations and Big Pharma first demonstrating the technique in 1996, the road was now ready for the field’s valorization. The next decade of key FBDD publications would almost exclusively ... See full document

24

ELRIG Investing in Early Stage Drug Discovery An Investor s Perspective YOURLOGO

ELRIG Investing in Early Stage Drug Discovery An Investor s Perspective YOURLOGO

... enables discovery of novel immuno-oncology therapeutics Platform has already delivered 2 orally bioavailable, compounds into clinical trials Macrophage Therapeutic’s portfolio consists of: – CHR-2845 – targeted ... See full document

21

Drug discovery FAQs: workflows for answering multidomain drug discovery questions

Drug discovery FAQs: workflows for answering multidomain drug discovery questions

... computational drug discovery can be ...turing drug discovery data in a way that helps scientists to understand the relations that exist between concepts in specialized ... See full document

7

Academic Drug Discovery in the Center for Integrative Chemical Biology and Drug Discovery

Academic Drug Discovery in the Center for Integrative Chemical Biology and Drug Discovery

... Center For Integrative Chemical Biology & Drug Discovery CENTER Mission Target Proposals from UNC Faculty “responsive collaborations” ONCOLOGY FOCUS Center Initiated Proj[r] ... See full document

20

Toxins and drug discovery

Toxins and drug discovery

... many drug discovery projects, with some notable ...toxin discovery to approval of a new medicine. Drug discovery and development is an inherently risky business, and the main causes of ... See full document

8

Antibiotic drug discovery

Antibiotic drug discovery

... product discovery has undergone a tremendous develop- ment over the past few ...revolutionizing drug discovery and development techniques, which is initiating a ‘New Age of Antibiotic ... See full document

8

Pyrazoles in Drug Discovery

Pyrazoles in Drug Discovery

... The pyrazole fragment may serve as a bioisostere to replace an arene or a hetarene with improved potency and physiochemical properties such as lipophilicity and aqueous solubility, etc. In addition, as an H-bond donating ... See full document

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