• No results found

[PDF] Top 20 Mammalian Adaptation in the PB2 Gene of Avian H5N1 Influenza Virus

Has 10000 "Mammalian Adaptation in the PB2 Gene of Avian H5N1 Influenza Virus" found on our website. Below are the top 20 most common "Mammalian Adaptation in the PB2 Gene of Avian H5N1 Influenza Virus".

Mammalian Adaptation in the PB2 Gene of Avian H5N1 Influenza Virus

Mammalian Adaptation in the PB2 Gene of Avian H5N1 Influenza Virus

... Mammalian Adaptation in the PB2 Gene of Avian H5N1 Influenza Virus Ji-Young Min, a * Celia Santos, a Adam Fitch, b Alan Twaddle, b Yoshiko Toyoda, b Jay ... See full document

5

PB2 Mutations D701N and S714R Promote Adaptation of an Influenza H5N1 Virus to a Mammalian Host

PB2 Mutations D701N and S714R Promote Adaptation of an Influenza H5N1 Virus to a Mammalian Host

... IMPORTANCE Influenza A/H5N1 viruses are avian pathogens that have pandemic potential, since they are spread over large parts of Asia, Af- rica, and Europe and are occasionally transmitted to ...the ... See full document

8

The avian influenza A/H5N1 virus

The avian influenza A/H5N1 virus

... 1918 influenza pandemic caused an estimated 40–60 mil- lion deaths, possibly 100 million, and 500,000–675,000 in the United ...1918 virus were theo- rized to be due to several factors: the preferred binding ... See full document

18

protein of avian influenza virus H5N1

protein of avian influenza virus H5N1

... of avian influenza, the non-structural (NS) -1 protein of avian influenza virus (AIV) H5N1 has shown promising potential for its ability to effectively stimulate the host ...NS1 ... See full document

10

The Effect of the PB2 Mutation 627K on Highly Pathogenic H5N1 Avian Influenza Virus Is Dependent on the Virus Lineage

The Effect of the PB2 Mutation 627K on Highly Pathogenic H5N1 Avian Influenza Virus Is Dependent on the Virus Lineage

... by PB2 627K in the 50-92 genetic background used here remains ...the PB2 gene independent of its role in the polymerase ...50-92 PB2 by a single nucleotide change, ...the PB2 627 region ... See full document

14

Mammalian Adaptation of an Avian Influenza A Virus Involves Stepwise Changes in NS1

Mammalian Adaptation of an Avian Influenza A Virus Involves Stepwise Changes in NS1

... O/03 virus blocked the induction of ISGs at a pretranscriptional level and that this involved the JAK/STAT pathway, since the JAK/STAT signaling pathway, upon IFN stimulation, leads to the transcription of ISGs ... See full document

21

Mammalian Adaptive Mutations of the PA Protein of Highly Pathogenic Avian H5N1 Influenza Virus

Mammalian Adaptive Mutations of the PA Protein of Highly Pathogenic Avian H5N1 Influenza Virus

... the adaptation of avian influenza viruses to mammalian hosts, no H5N1 virus has yet acquired the ability to transmit effi- ciently between ...of H5N1 highly pathogenic ... See full document

9

H5N1 Avian Influenza Virus Induces Apoptotic Cell Death in Mammalian Airway Epithelial Cells

H5N1 Avian Influenza Virus Induces Apoptotic Cell Death in Mammalian Airway Epithelial Cells

... of H5N1 virulence, such as cytopathicity, in part because of a lack of suitable in vitro infection systems that properly mimic the human airway ...of H5N1 in humans is based on virus-induced ... See full document

14

Emergence of Mammalian Species-Infectious and -Pathogenic Avian Influenza H6N5 Virus with No Evidence of Adaptation

Emergence of Mammalian Species-Infectious and -Pathogenic Avian Influenza H6N5 Virus with No Evidence of Adaptation

... of influenza A viruses. Of the 16 hemagglutinin subtypes of avian influenza viruses, the H6 subtype is commonly perpetuated in its natural hosts and is of concern due to its potential to be a ... See full document

7

Amino Acid Residues 253 and 591 of the PB2 Protein of Avian Influenza Virus A H9N2 Contribute to Mammalian Pathogenesis

Amino Acid Residues 253 and 591 of the PB2 Protein of Avian Influenza Virus A H9N2 Contribute to Mammalian Pathogenesis

... in PB2 of H9N2/G1 viruses enhance poly- merase activity in minirelicon assays and increase virus repli- cation competence on primary human macrophages, embryo- nated chicken eggs, and well-differentiated ... See full document

5

The NS1 Gene Contributes to the Virulence of H5N1 Avian Influenza Viruses

The NS1 Gene Contributes to the Virulence of H5N1 Avian Influenza Viruses

... of avian influenza viruses in chickens. The GS/GD/2/96 virus replicated without causing death in the allantoic cavity of 10-day-old embryonated embryos and was not able to replicate in chickens after ... See full document

9

An Avian Influenza H5N1 Virus That Binds to a Human-Type Receptor

An Avian Influenza H5N1 Virus That Binds to a Human-Type Receptor

... the virus to transmit from person to person ...an adaptation of H5N1 virus to the human host by receptor binding site modification could and did indeed ... See full document

6

Adaptation of avian influenza virus to a swine host

Adaptation of avian influenza virus to a swine host

... duck influenza virus to swine respiratory ...this adaptation. We compare the in vitro growth dynamics of the adapted virus with those of the original strain as well as all possible ... See full document

11

Virulence Determinants of Avian H5N1 Influenza A Virus in Mammalian and Avian Hosts: Role of the C-Terminal ESEV Motif in the Viral NS1 Protein

Virulence Determinants of Avian H5N1 Influenza A Virus in Mammalian and Avian Hosts: Role of the C-Terminal ESEV Motif in the Viral NS1 Protein

... influenza virus. To examine the role of the PDZ domain ligand motif in avian influenza virus virulence, we generated three recombinants, derived from the prototypic H5N1 ... See full document

11

NP, PB1, and PB2 Viral Genes Contribute to Altered Replication of H5N1 Avian Influenza Viruses in Chickens

NP, PB1, and PB2 Viral Genes Contribute to Altered Replication of H5N1 Avian Influenza Viruses in Chickens

... parental virus’ functional polymerase complexes by exchanging PB1 or PB2 genes decreased viral replication in tissues and consequently the pathogenicity of the ...NP gene greatly increased viral ... See full document

10

Characterization of the Influenza A Virus Gene Pool in Avian Species in Southern China: Was H6N1 a Derivative or a Precursor of H5N1?

Characterization of the Influenza A Virus Gene Pool in Avian Species in Southern China: Was H6N1 a Derivative or a Precursor of H5N1?

... for influenza A viruses, we characterized virus subtypes isolated from these birds in Hong Kong during the H5N1 outbreak to gain information about the gene pool in this area and to investigate ... See full document

7

Mammalian innate resistance to highly pathogenic avian influenza H5N1 virus infection is mediated through reduced proinflammation and infectious virus release

Mammalian innate resistance to highly pathogenic avian influenza H5N1 virus infection is mediated through reduced proinflammation and infectious virus release

... of influenza A virus ...pathogenic avian influenza (HPAI) H5N1 virus (A/turkey/Turkey/1/05) and a moderately patho- genic human influenza H1N1 virus (A/USSR/77), ... See full document

11

Mammalian Innate Resistance to Highly Pathogenic Avian Influenza H5N1 Virus Infection Is Mediated through Reduced Proinflammation and Infectious Virus Release

Mammalian Innate Resistance to Highly Pathogenic Avian Influenza H5N1 Virus Infection Is Mediated through Reduced Proinflammation and Infectious Virus Release

... of influenza A virus ...pathogenic avian influenza (HPAI) H5N1 virus (A/turkey/Turkey/1/05) and a moderately patho- genic human influenza H1N1 virus (A/USSR/77), ... See full document

10

Protection against a Lethal Avian Influenza A Virus in a Mammalian System

Protection against a Lethal Avian Influenza A Virus in a Mammalian System

... potential influenza pandemic has been raised by the recent outbreak caused by an avian H5N1 virus in Hong ...laboratory-adapted H5N1 strain isolated previously from ...the H5N1 ... See full document

7

Rapid emergence of a virulent PB2 E627K variant during adaptation of highly pathogenic avian influenza H7N7 virus to mice

Rapid emergence of a virulent PB2 E627K variant during adaptation of highly pathogenic avian influenza H7N7 virus to mice

... a mammalian host, we passaged an avian H7N7/03 outbreak isolate in mouse lungs and evaluated the phenotype of the mouse-adapted variant in animal models and in ...The virus had a MLD 50 that was ... See full document

11

Show all 10000 documents...