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[PDF] Top 20 Measles virus nucleocapsid protein increases osteoblast differentiation in Paget’s disease

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Measles virus nucleocapsid protein increases osteoblast differentiation in Paget’s disease

Measles virus nucleocapsid protein increases osteoblast differentiation in Paget’s disease

... OB differentiation and whether these effects were blocked by anti-IGF1 or ...OB differentiation to the same extent in MVNP-OCL and MVNP-OB cocultures (Figure ... See full document

12

Osteoclasts expressing the measles virus nucleocapsid gene display a pagetic phenotype

Osteoclasts expressing the measles virus nucleocapsid gene display a pagetic phenotype

... We have shown previously that IL-6 appears to be an autocrine/paracrine factor that stimulates OCL forma- tion in patients with Paget’s disease (19). IL-6 levels are markedly increased in the marrow from patients ... See full document

9

Paget’s disease of bone: an osteoimmunological disorder?

Paget’s disease of bone: an osteoimmunological disorder?

... Paget’s disease of bone is a common metabolic bone disorder, resulting from an excessively increased bone resorption coupled with aberrant bone ...to measles virus nucleocapsid protein ... See full document

13

Paget disease of bone

Paget disease of bone

... infectious virus has not been ...syncytial virus and measles virus nucleocapsid protein (MVNP) ...MVNP protein was present in osteoclasts and/or cultured bone cells from ... See full document

10

Current perspectives on bisphosphonate treatment in Paget’s disease of bone

Current perspectives on bisphosphonate treatment in Paget’s disease of bone

... the effects of symptomatic treatment with intensive bispho- sphonates therapy in 1,324 patients with Paget’s disease of bone, with a median follow-up period of 3 years (ranging from 2 to 5 years). The symptomatic ... See full document

7

FOXOs attenuate bone formation by suppressing Wnt signaling

FOXOs attenuate bone formation by suppressing Wnt signaling

... The high bone-mass phenotype of the mice with the targeted Foxo deletion of the present report was maintained up to 24 months of age, suggesting that the increase in β-catenin/TCF-mediated transcription was maintained ... See full document

12

Emerging strategies and therapies for treatment of Paget’s disease of bone

Emerging strategies and therapies for treatment of Paget’s disease of bone

... Paget’s disease of bone (PDB) is a progressive monostotic or polyostotic metabolic bone disease characterized by focal abnormal bone remodeling, with increased bone resorption and excessive, disorganized, ... See full document

15

Recognition of the Measles Virus Nucleocapsid as a Mechanism of IRF-3 Activation

Recognition of the Measles Virus Nucleocapsid as a Mechanism of IRF-3 Activation

... a protein gradient with the highest production of 3⬘ genes and the lowest for those at the 5⬘-most extremities (L) (step 1, ...N protein itself induces the switch from transcription to replication through ... See full document

12

A Single Codon in the Nucleocapsid Protein C Terminus Contributes to In Vitro and In Vivo Fitness of Edmonston Measles Virus

A Single Codon in the Nucleocapsid Protein C Terminus Contributes to In Vitro and In Vivo Fitness of Edmonston Measles Virus

... Sindbis virus (6), foot-and-mouth disease virus (5), and eastern equine enceph- alitis virus ...N protein and 73 nt of the downstream noncoding sequence (nt 1491 to 1758 of the N gene) ... See full document

9

Mutation of the sequestosome 1 (p62) gene increases osteoclastogenesis but does not induce Paget disease

Mutation of the sequestosome 1 (p62) gene increases osteoclastogenesis but does not induce Paget disease

... Paget disease is the most exaggerated example of abnormal bone remodeling, with the primary cellular abnormality in the ...familial Paget disease and in a minority of patients with sporadic ... See full document

11

Sequence of Events in Measles Virus Replication: Role of Phosphoprotein-Nucleocapsid Interactions

Sequence of Events in Measles Virus Replication: Role of Phosphoprotein-Nucleocapsid Interactions

... a protein harboring the substitution(s) of interest and in rescuing a mutant virus (see, ...complete virus replication (see, ...recombinant virus lacking expression of the P gene in a ... See full document

13

Functional Redundancy in HIV-1 Viral Particle Assembly

Functional Redundancy in HIV-1 Viral Particle Assembly

... the nucleocapsid (NC) domain (the primary RNA-binding domain of the Gag protein) is replaced with a leucine-zipper dimerization domain assemble efficiently in mammalian cells (1, 8, 19, ... See full document

6

LIGHT/TNFSF14 increases osteoclastogenesis and decreases osteoblastogenesis in multiple myeloma-bone disease

LIGHT/TNFSF14 increases osteoclastogenesis and decreases osteoblastogenesis in multiple myeloma-bone disease

... bone disease associated with rheumatoid ...bone disease, LIGHT inhibited the formation of CFU-F and CFU-OB as well as the expression of osteoblastic markers including collagen-I, osteocalcin and bone ... See full document

18

Oligomerization of Uukuniemi virus nucleocapsid protein

Oligomerization of Uukuniemi virus nucleocapsid protein

... N protein localizes in transfected cells and whether there are differences in the staining pattern ...N protein localized in the cytoplasm and formed larger aggregates ...stained protein aggre- ... See full document

13

Baculovirus AC102 Is a Nucleocapsid Protein That Is Crucial for Nuclear Actin Polymerization and Nucleocapsid Morphogenesis

Baculovirus AC102 Is a Nucleocapsid Protein That Is Crucial for Nuclear Actin Polymerization and Nucleocapsid Morphogenesis

... DNA virus that infects lepidopteran insects and is commonly known as a vector for protein expres- sion and cell ...a nucleocapsid protein and a newly recognized member of a complex consisting ... See full document

17

Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant

Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant

... DNA-binding protein 43 kDa (TDP-43), phosphorylated TDP-43, ubiquitin (Ub), p62, and optineurin were identified in the spinal and medullary motoneurons, but not in the ...’ s compared with wild-type ... See full document

14

The Andes Virus Nucleocapsid Protein Directs Basal Endothelial Cell Permeability by Activating RhoA

The Andes Virus Nucleocapsid Protein Directs Basal Endothelial Cell Permeability by Activating RhoA

... Syx, Vav2, and p115RhoGEF) (48–50, 69, 71) are engaged by ANDV infection or N expression to constitutively activate RhoA. ANDV-induced MEC permeability is blocked by inhibition of RhoA. Activation of RhoA directs actin ... See full document

12

Tyrosine phosphorylation of measles virus nucleocapsid protein in persistently infected neuroblastoma cells.

Tyrosine phosphorylation of measles virus nucleocapsid protein in persistently infected neuroblastoma cells.

... human disease of the central nervous system which is a delayed sequel of measles virus (MV) ...the virus and mostly affects young adults between 5 and 14 years old (5, 25, ...this ... See full document

6

Identification and Characterization of a Regulatory Domain on the Carboxyl Terminus of the Measles Virus Nucleocapsid Protein

Identification and Characterization of a Regulatory Domain on the Carboxyl Terminus of the Measles Virus Nucleocapsid Protein

... N protein C-terminal sequences or the MV nucleocapsid was analyzed by using BIAcore3000 (Pharmacia, Uppsala, Sweden), a system for real-time biomolecular interaction analysis that is based upon surface ... See full document

10

Molecular strategies for the detection
of measles virus in
inflammatory bowel disease

Molecular strategies for the detection of measles virus in inflammatory bowel disease

... ... Measles virus is not present ... Measles virus RNA is present but not detectable ... Measles virus and autistic enteropathy .... The increasing incidence of Crohn's disease [r] ... See full document

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