[PDF] Top 20 Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans
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Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans
... in net hepatic glycogenolysis and stimulation of net hepatic glycogen synthesis exclusively through activation of glycogen synthase flux (protocol II versus ...to inhibit ... See full document
8
Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling
... or glucose-supplemented ...obesity, glucose intolerance, and hepatomegaly as compared to glucose-supplemented HFD mice, despite similar caloric ...and glucose supplementation also had distinct ... See full document
17
The physiological regulation of glucose flux into muscle in vivo
... of hepatic glucose production in the sedentary state (Liljenquist et ...of glucose production necessary to maintain blood glucose (Wasserman, ...whereas insulin secretion from the ... See full document
9
No Dose Response Relationship in the Effects of Commonly Consumed Sugars on Risk Factors for Diabetes across a Range of Typical Human Consumption Levels
... biologic mechanism for the relationship between fructose containing sugars and obesity, diabetes, and other cardiometabolic ...including insulin resistance, hypertension, obesity, and dyslipidemia ... See full document
12
Skeletal muscle glycogenolysis is more sensitive to insulin than is glucose transport/phosphorylation Relation to the insulin mediated inhibition of hepatic glucose production
... rats. Insulin was infused for 120 min at rates of ...endogenous insulin release was inhibited by SRIF infusion and plasma glucose was maintained at the basal ...muscle glucose-6-phosphate ... See full document
13
Effects of free fatty acids on glucose transport and IRS 1–associated phosphatidylinositol 3 kinase activity
... muscle glucose metabolism was asso- ciated with a >90% reduction in the insulin-stimulated increase in glucose-6-phosphate ...concentrations inhibit insulin activation of ... See full document
8
Effect of dexamethasone on hepatic glucose and insulin metabolism after oral glucose in conscious dogs
... of insulin or also involves altered fractional hepatic extraction, oral glucose (1 g/kg body wt) was administered to dogs with or without dexamethasone treatment (2 mg/d for 2 ...basal glucose ... See full document
8
Effect of prior exercise on the partitioning of an intestinal glucose load between splanchnic bed and skeletal muscle
... and glucose-stimulated (2, 4, 5, 8) insulin levels are often ...circulating insulin at the muscle (9). However, it is unclear whether hepatic sensitivity to insulin or any other ... See full document
12
Direct muscarinic cholinergic inhibition of hepatic glucose production in humans
... concentration (101 +/- 8 to 75 +/- 8 mg/dl, P less than 0.05). When compared with separate clamp control studies (with placebo rather than bethanechol injection) both the rate of glucose production and the ... See full document
6
Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats Implications for the pathophysiology of fasting hyperglycemia in diabetes
... plasma glucose concentration (PG) and the pathways of hepatic glucose production (HGP), five groups of conscious rats were studied after a 6-h fast: (a) control rats (PG = ...and insulin ... See full document
10
CHLORPROPAMIDE INDUCED LEUCINE HYPOGLYCEMIA
... It is suggested that L-leucine acts similarly in all situations to inhibit hepatic glucose output and that the resultant fall in blood glucose concentration will vary considerably, depen[r] ... See full document
10
PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans
... of insulin secretion has also been reported in two studies using PKCδ transgenic mouse models (36, 37), but the results of the latter were conflicting as to the direction of ...in glucose infusion rate ... See full document
15
Assessment of insulin action and glucose effectiveness in diabetic and nondiabetic humans
... euglycemia, insulin increased glucose disposal in nondiabetic but not diabetic subjects indicating marked extrahepatic ...contrast, insulin- induced suppression of glucose release was only ... See full document
9
Adrenergic blockade alters glucose kinetics during exercise in insulin dependent diabetics
... on glucose homeostasis during exercise in six normal subjects and in seven Type I diabetic ...dose insulin infusion (0.07 mU/kg X min) designed to maintain plasma glucose at approximately 150 ... See full document
12
Oral Anti-Diabetic Agents-Review and Updates
... inadequate insulin secretion, failure of insulin to elicit normal level of response in insulin sensitive tissue (insulin resistance), or both ... See full document
26
Glucose and free fatty acid metabolism in non insulin dependent diabetes mellitus Evidence for multiple sites of insulin resistance
... and net lipid oxidation (measured by indirect calorimetry) correlated positively with the rate of HGP in the basal state and during the insulin ...that insulin resistance is a general characteristic ... See full document
10
The role of hepatic insulin receptors in the regulation of glucose production
... allow insulin to reduce HGP to some ...that insulin clear- ance did not change despite the change in hepatic insulin receptor ...liver insulin receptors in insulin degradation ... See full document
5
Glucose Disposal during Insulinopenia in Somatostatin Treated Dogs: THE ROLES OF GLUCOSE AND GLUCAGON
... of glucose on the ...the insulin level basal (7±1 µU/ml) and the glucagon levels reduced (16±2 pg/ml), hyperglycemia (mean increment of 130 mg/dl) promoted marked net hepatic glucose ... See full document
6
<p>A Recent Achievement In the Discovery and Development of Novel Targets for the Treatment of Type-2 Diabetes Mellitus</p>
... including glucose-lowering agents like which suppress hepatic glucose production and increase glucose uptake, insulin secretagogues, like sulphonylureas and meglitinides, ... See full document
15
Importance of the route of intravenous glucose delivery to hepatic glucose balance in the conscious dog
... 90-min glucose infusion ...randomized. Insulin and glucagon were held at constant basal levels using somatostatin and intraportal insulin and glucagon infusions during the control, portal, and ... See full document
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