[PDF] Top 20 Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial function
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Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial function
... Saturated fatty acids activate inflammatory signaling pathways directly through interaction with members of Toll-like receptor (TLR) family and indirectly through the secretion of cytokines including TNF- a ... See full document
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Ameliorative effects of polyunsaturated fatty acids against palmitic acid-induced insulin resistance in L6 skeletal muscle cells
... unsaturated fatty acids, oleic acid has been a focus of many ...other fatty acids would depend, at least in part, on PPARa because of its high affinity for unsatu- rated fatty ... See full document
9
Inactivation of fatty acid transport protein 1 prevents fat induced insulin resistance in skeletal muscle
... member fatty acid translocase/CD36, and members of the fatty acid–binding protein (FABP) family have also been implicated in playing a role in fatty acid uptake into cells (22, 23, 34, ...mediate ... See full document
9
Insulin sensitivity: modulation by nutrients and inflammation
... of skeletal muscle to oxidize fatty acids when fatty acid flux is high (such as in obesity) would lead to an accumulation of fatty acid intermediates; activation of the JNK, IKK, ... See full document
12
Fish oil omega 3 fatty acids partially prevent lipid induced insulin resistance in human skeletal muscle without limiting acylcarnitine accumulation
... within skeletal muscle are a major cause of insulin resistance in sedentary individuals [1, ...impair insulin-stimulated glucose uptake, the mechanisms by which this may occur in ... See full document
21
Conjugated linoleic acid or omega 3 fatty acids increase mitochondrial biosynthesis and metabolism in skeletal muscle cells
... increased fatty acid oxidation ...of fatty acid utilization [23]. Moreover, CLA is purported to reduce fatty acid synthesis in adipocytes, suggesting that CLA discourages fat deposition directly ... See full document
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Skeletal muscle mechanics, energetics and plasticity
... muscle function. Specifically, he identifies the merits of analyzing muscle deformations in three di- mensions (rather than just two), because of the potential decoupling of the parallel elastic ... See full document
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Angiotensin-converting enzyme 2 regulates endoplasmic reticulum stress and mitochondrial function to preserve skeletal muscle lipid metabolism
... stained skeletal muscle ...drial function-related ...the skeletal muscle of the Ad-ACE2-treated mice ...the skeletal muscle lipid metabolism in ... See full document
8
Intracellular localization of diacylglycerols and sphingolipids influences insulin sensitivity and mitochondrial function in human skeletal muscle
... reporting mitochondrial/ER sphingolipid content in humans spanning a range of insulin sensitivity, with C18:0 ceramide inversely related to insulin ...potential mechanisms that could explain ... See full document
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The effect of insulin treatment and exercise modality on skeletal muscle fiber size in streptozotocin-induced type 1 diabetic rats
... on skeletal muscle mass and function, collectively termed diabetic myopathy, has been reported to result in a preferential atrophy of glycolytic muscle fibers compared to oxidative ... See full document
149
Reduced mitochondrial density and increased IRS 1 serine phosphorylation in muscle of insulin resistant offspring of type 2 diabetic parents
... and insulin signaling in muscle biopsy samples obtained from these individuals before and during a hyperinsulinemic-euglycemic ...of insulin-stimulated muscle glucose uptake was approximately ... See full document
8
TAK1 regulates skeletal muscle mass and mitochondrial function
... inhibits muscle wasting in multiple catabolic conditions, including denervation (38, 54, ...denervation-induced muscle atrophy remain ...atrophying skeletal muscle (1, ... See full document
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Manifestation of renal disease in obesity: pathophysiology of obesity-related dysfunction of the kidney
... tensive patients with OSA versus hypertensive patients without OSA by formal polysomnography. Participants were matched for age, sex, smoking status, BMI, 24-hour pulse pressure, with exclusion if impaired glucose ... See full document
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G-PROTEIN COUPLED RECEPTORS FOR FREE FATTY ACIDS AS NOVEL TARGETS FOR TYPE 2 DIABETES
... of fatty acids are different and GPR40 mediates both the ...of fatty acid levels causes increase in release of insulin from β cells, which lead to hyperinsulinemia, hepatic steatosis, glucose ... See full document
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Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans
... to insulin resistance in skeletal muscle, and this represents a major risk factor for type 2 diabetes and cardiovascular ...disease. Mitochondrial dysfunction and oxidative stress have ... See full document
10
Glucose toxicity and the development of diabetes in mice with muscle specific inactivation of GLUT4
... selective muscle insulin resist- ance, we also observed a significant decrease in insulin-stimulated glucose uptake in white and brown adipose tissue, as well as hepatic insulin resist- ance ... See full document
9
The effect of diet and exercise on lipid droplet dynamics in human muscle tissue
... in skeletal muscle are subject to enduring cycles of hydrolysis and ...– mitochondrial contact sites (Bosma et ...of fatty acids from LD lipolysis to the mitochondrial oxidative ... See full document
12
Altered skeletal muscle (mitochondrial) properties in patients with mitochondrial DNA single deletion myopathy
... the mitochondrial and/or nuclear DNA [41, ...of mitochondrial myopathy can be lacking despite presence of a mito- chondrial disease ...of mitochondrial DNA in tissues may demonstrate hetero- plasmic ... See full document
12
Malleability of the motor system: training for maximizing power output
... Mitochondrial volume density in human skeletal muscle following heavy resistance training.. Biochemical adaptation of human.[r] ... See full document
10
Skeletal muscle inflammation and insulin resistance in obesity
... with insulin resis- tance or T2D secrete more cytokines such as TNF-α and chemo- kines such as monocyte chemoattractant protein 1 (MCP-1) than myocytes from lean controls (31, 34, ...induce insulin ... See full document
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