[PDF] Top 20 Mechanistic regulation of HMGB1 function in drug-induced liver injury

... of HMGB1. A detailed review of HMGB1 post-translational modifications is given in section ...of HMGB1 is to facilitate transcription through manipulation of nucleosome complexes (Sutrias-Grau et ... See full document

... of drug-induced cardiotoxicity – a primary cause of drug ...of drug-induced cardiotoxicity, in contrast with the rather pleiotropic and diverse manifestations of hepatotoxicity, at the ... See full document

... Mrp2 function, ...investigate drug-drug interactions mediated by inhibition of hepatobiliary excretion, and to elucidate the consequences of protein induction (Annaert et ...up- regulation of ... See full document

... minimise injury and its ...when liver injury manifests (called positive rechallenge), [58] the consequences could be serious including mortality in 2% to 13% of cases [59, ... See full document

... ii Drug induced liver injury (DILI) is a major cause of patient morbidity and mortality inferring considerable burdens onto healthcare and pharmaceutical ...from induced pluripotent ... See full document

... are identified in table 1.3. However, covalent binding is not always indicative of toxicity and recently studies have been undertaken to try and gain a greater understanding of the relationship between covalent binding ... See full document

... Polymorphonuclear leukocytes (PMNs) were prepared from peripheral blood or CSF and a cytospin was used to immobilize them on slides. After cytospin centrifuga- tion, slides were fixed for 15 min. Polymorphonuclear ... See full document

... Toxicity frequently occurs in the liver, because this organ is responsible for breaking down many xenobiotic compounds. Although many models have been developed for toxicity pathways, currently there are only a ... See full document

... A-induced liver injury, we first evaluated the difference in liver function tests among Con A and Con A + MGL administered ...the liver injury score was also improved in ... See full document

... example, it protects against free radicals produced by xenobiotics or their metabolites. It is capable of binding to potentially harmful electrophilic compounds through two mechanisms: first, it can protect protein ... See full document

... antisocial drug is the vital in preventing a reappearance of the Drug Induced Liver ...adverse drug reaction as the cause of liver disease may allow an initially minor reaction ... See full document

... An issue raised by several previous studies is that COX-2 is also involved in anti-inflammatory properties, although COX-2 is generally thought to have an important role in the induction of inflammatory response and has ... See full document

... developing specific agents to identify which chemical entities are entirely safe” with animal testing and other rigorous methods are the most important steps in drug development. The reasons include differences in ... See full document

... the complication of VBDS have been reported by far and all were children. The first case was reported by Alam at el in 1996, which indicated that VBDS was temporally as- sociated with ibuprofen [8]. Subsequently, Kim et ... See full document

... Drug-induced liver injury is a rare event. We report on a 15-year old girl de- veloping jaundice and a maculopapular rash with pruritus after oral cefu- roxime therapy. Liver enzymes as ... See full document

... of more efficient and less traumatic oxygenators and blood pumps. The centrifugal pumps, particularly the newer second generation pumps (Rotaflow, Cobe Revolu- tion) were reported to result in reduced transfusion re- ... See full document

... kidney injury provoked by ferric nitrilotriacetate, 31 cisplatin, 3 aristolochic acid, 32 and ischemia reperfusion 19 has only been demonstrated following repeated daily dosing of the triterpenoids, implying that ... See full document

... the liver enzymes remained elevated with an ALT of 334 U/L, AST 229 U/L, and a total bilirubin of ...A liver biopsy was performed which prompted a referral to the liver center at the University of ... See full document

... with liver diseases and other serious life-threatening comorbidities 12-14 ...accelerate liver toxicity and limit their benefits. Hence, drug prescription for severe psoriasis treatment requires ... See full document

... In liver injury enzymes were leaked into blood because of enhanced permeability, injury and necrosis of hepatocytes. Hence SGPT, SGOT and ALP levels are elevating in liver toxicity. [25] In ... See full document