[PDF] Top 20 Metabolic biomarkers for response to PI3K inhibition in basal like breast cancer
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Metabolic biomarkers for response to PI3K inhibition in basal like breast cancer
... the PI3K signal- ing inhibitors MK-2206 and BEZ235 inhibited prolifera- tion and inhibited tumor growth in a basal-like xenograft ...The response correlated to the inhibition of Akt ... See full document
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Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-Like Breast Cancer
... growth inhibition under hypoxia or by ...this metabolic switch empowers them to absorb glucose and maintain ATP level under dearth nutrient and hypoxic ...from inhibition by immune response at ... See full document
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Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer
... growth inhibition under hypoxia or by ...this metabolic switch empowers them to absorb glucose and maintain ATP level in a nutrient-poor and hypoxic ...from inhibition by an immune response at ... See full document
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Triple Negative Breast Cancer Characteristics Based on Basal-like and Non-Basal-like Subtypes
... In this study, more than 50% subjects (32 out of 57 subjects) were given adjuvant chemotherapy because it is suggested for TNBC and HER2 + subjects in the early up to locally advanced. The TNBC subjects negative who had ... See full document
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Experimental targeting of basal-like breast cancer in vitro
... protein was only suppressed in one BLBC (MDA-MB-231) and in one reference cell (MCF-7). The phospo-IκB-α was downregulated in all six cells whereas the unphosphorylated form was only inhibited in SKBR-3 and MDA-MB-231 ... See full document
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SRC inhibition prevents P-cadherin mediated signaling and function in basal-like breast cancer cells
... BLBC: Basal-like breast cancer; FAK: Focal adhesion kinase; FDA: USA Food and Drug Administration; p120ctn: p120 catenin; SRC: Src family kinase ...this basal marker affects: 1) ... See full document
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Distinct choline metabolic profiles are associated with differences in gene expression for basal-like and luminal-like breast cancer xenograft models
... relevant metabolic reactions governs the metabo- lite concentrations, and the relative importance of each metabolic reaction is ...in metabolic pat- ... See full document
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Genome remodelling in a basal-like breast cancer metastasis and xenograft.pdf
... Basal-like breast cancer is characterized by the absence of oestrogen receptor (ER) expression, the lack of ERBB2 gene amplification, and a high mitotic ...poor response to standard ... See full document
7
Activating senescence in p16-positive Basal-like breast cancer.
... (HER2)-negative breast cancer (Harding, ...HER2-negative breast cancer when compared to Fulvestrant alone (reviewed in Mayer, ...growth inhibition in HER2-positive breast ... See full document
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Inhibition of super enhancer downregulates the expression of KLF5 in basal-like breast cancers
... in basal-like breast cancer (BLBC), which promotes cell proliferation, survival, migration and stemness, serving as a potential therapeutic ... See full document
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Inhibition of basal like breast cancer growth by FTY720 in combination with epidermal growth factor receptor kinase blockade
... Results: Quantitated by live-cell imaging, the inhibitor combination showed synergistic cytostatic activity in basal- like cell lines across several TNBC molecular subtypes, the synergy being decreased by ... See full document
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Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype.pdf
... Core Basal over 5NP tumors in the adjuvant anthracycline subset) are best considered hypothesis ...Core Basal definition may predict response of anthracycline-based adjuvant chemo- therapies needs ... See full document
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The SOX11 transcription factor is a critical regulator of basal-like breast cancer growth, invasion, and basal-like gene expression.
... that inhibition of 8 of the 33 candidates resulted in reduced growth of at least two of three BLBC cell lines ...growth, inhibition of SOX11 had the most BLBC-specific effect, suppressing growth in all ... See full document
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Identification and evaluation of network modules for the prognosis of basal-like breast cancer
... Interestingly, pathway analysis of the individual BLBC modules suggested that each module was generally representative of a biological program that, depending on expression characteristics, was associated with either ... See full document
12
Integrated Molecular Pathway Analysis Informs a Synergistic Combination Therapy Targeting PTEN/PI3K and EGFR Pathways for Basal-Like Breast Cancer
... of PI3K pathway and EGFR inhibitors in vitro suggest that targeting both PI3K and EGFR pathways may be a rational strategy for the treatment of ...inhibiting PI3K and EGFR in vivo using a mouse ... See full document
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Immunoglobulin free light chains are biomarkers of poor prognosis in basal-like breast cancer and are potential targets in tumor-associated inflammation
... well. Inhibition of FLCs by the antagonist F991, a peptide which binds to FLC [19, 37], greatly reduced melanoma tumor ...slowing cancer growth and improving specific survival ... See full document
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Association between mammographic density and basal like and luminal A breast cancer subtypes
... Many recent studies have emphasized etiologic hetero- geneity by intrinsic subtype. It is important to recognize that intrinsic subtype classification was greatly influenced by clinical needs and is based on ... See full document
10
Proteogenomic analysis of Inhibitor of Differentiation 4 (ID4) in basal-like breast cancer
... ovarian cancer (HGSOC), by combining RIME proteomic analysis, ChIP-seq mapping of genomic binding sites and ...damage response proteins, in particular, mediator of DNA damage checkpoint protein 1 ... See full document
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FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer
... of basal cell carcinoma. Hh inhibition is also in clinical trials for triple-negative breast cancers ...render cancer cells refractory to SMO-tar- geting ... See full document
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The SIRT2 Deacetylase Stabilizes Slug to Control Malignancy of Basal-like Breast Cancer
... aggressive basal subtype of breast cancer, which is most strongly associated with the phe- nomenon of Slug ...pharmacological inhibition of SIRT2 in Slug-stabilizing BLBC cells, the ... See full document
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