[PDF] Top 20 Metabolomics based profiling of Dexamethasone side effects in rats

... immunosuppressant effects and is used in several conditions such as asthma and severe ...several side effects such as hyperglycemia, weight change, or osteoporosis due to its in vivo ...metabolomic ... See full document

... the effects of separate and combined intraperitoneal (IP) injections of histidine and dexamethasone were investigated on local inflammation in ...and dexamethasone at a dose of 1 mg kg -1 ... See full document

... anti-oxidant effects of curcumin in dexamethasone-induced dyslipidemia in ...rats. Rats classified into five groups, contained six animals ...group: rats were injected subcutaneously ... See full document

... significant effects on bone metabolism in inflammatory ...real effects induced by the drugs or even reverse their original effects on bone, and vice ...potential effects of antiarthritics on ... See full document

... and dexamethasone (D) treatment increase plasma insulin and glucose levels and induce insulin ...treated rats without affecting mean daily food ...Wistar rats were divided into 4 ...of rats ... See full document

... Abstract: Glucocorticoids therapy is the most common cause of secondary iatrogenic osteoporosis.The bone loss occurs predominantly due to a decrease in bone formation, although increased bone resorption also occurs. ... See full document

... of dexamethasone in ascites formation may be attributed to its anti-inflammatory effect and to a decrease in the production of vasoactive substances from inflammatory cells, but not to improve liver functions and ... See full document

... increased side effects of steroids, including systemic adrenal suppression, generalized growth suppres- sion, osteoporosis, obesity, chronic hypertension, im- munosuppression, mood swings, poor sleep, ... See full document

... adverse effects, including insulin resistance, hyperinsulinemia and ...of dexamethasone to induce hyperinsulinemia in wistar ...of dexamethasone were administered intraperitoneal ...wistar ... See full document

... increased side effects of steroids, including systemic adrenal suppression, generalized growth suppres- sion, osteoporosis, obesity, chronic hypertension, im- munosuppression, mood swings, poor sleep, ... See full document

... in rats during the prenatal period significantly increased the COUP-TFII expression in fetal Leydig cells thus down-regulating Cyp17a1 expression and inhibiting testosterone production ...DEX-mediated ... See full document

... Since the purpose of this study was to determine the efficacy of oral dexamethasone in reducing headache and the gastrointestinal side effects associated with metriz[r] ... See full document

... An important limitation so far has been that pharmacometabolomic studies are often performed at single time points while many biological processes change with time. A single time point evaluation thus limits the ability ... See full document

... Keywords: GC-MS, abuse, biomarker, metabolite Introduction Ketamine (2-(2-chlorophenyl)-2-methylamino-cyclohexan-1-one) was first synthesized in 1962 as an anesthetic for human and animal therapeutic use. 1,2 It is a ... See full document

... neurological side effects has been said to be caused by non-competitive inhibition of an archetypal membrane –bound mechanosensitive sodium-hydrogen ion transporter known as NHE-1 by ...earlier side ... See full document

... The results showed that acute anesthesia significantly influenced the composition of serum in a very short period, such as the significant increase in glucose, and decrease in lactate. This indicates that it is better to ... See full document

... primarily dexamethasone, to decrease postsurgical pain after tonsillectomy is popular ...anti-inflammatory effects and might be expected to improve recovery after surgical ... See full document

... untargeted metabolomics to be used as a suitable high-throughput screening tool, however, it is important to obtain strong, reproducible markers, in this case for pathways which are well reported in CuO NP induced ... See full document

... Athletics that includes a group of competitive sports such as running, jumping, throwing, and walking showed higher concentrations of two xenobiotics that have potentially originated from food products and/or ... See full document

... untargeted metabolomics approach to determine the metabolic profile in response to ultramarathon ...the effects of ultramarathon distance running on the metabolic specificities and alterations that may ... See full document