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[PDF] Top 20 Metformin as a new anti-cancer drug in adrenocortical carcinoma

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Metformin as a new anti-cancer drug in adrenocortical carcinoma

Metformin as a new anti-cancer drug in adrenocortical carcinoma

... In metformin-treated H295R cells, we observed an increased AMPK phosphorylation, associated with a rapid glucose uptake, which is probably an adaptive compensatory mechanism to fuel ATP production through ... See full document

13

New insight for metformin against bladder cancer

New insight for metformin against bladder cancer

... of cancer in diabetic patients [8, ...of metformin significantly reduces the risk of cancers like breast [15], pancreatic [16] and prostate ...of cancer in patients with diabetes taking ... See full document

8

Current and Emerging Therapies for Adrenocortical Carcinoma – Review

Current and Emerging Therapies for Adrenocortical Carcinoma – Review

... Adrenocortical carcinoma (ACC) is a rare malignancy with poor ...option. New adjuvant treatment options, even after complete tumor removal, are desired because postoperative disease-free survival at ... See full document

9

2D-DIGE proteomic analysis identifies new potential therapeutic targets for adrenocortical carcinoma

2D-DIGE proteomic analysis identifies new potential therapeutic targets for adrenocortical carcinoma

... Adrenocortical carcinoma (ACC) is a rare aggressive tumor with poor prognosis when metastatic at ...the anti-cancer drugs currently ...between adrenocortical carcinoma and normal ... See full document

12

The challenge of developmental therapeutics for adrenocortical carcinoma

The challenge of developmental therapeutics for adrenocortical carcinoma

... Adrenocortical carcinoma (ACC) is a rare disease with an estimated incidence of only ...0.7 new cases per million per ...in cancer biology and genomics have fostered the development of ... See full document

16

Synthesis and Anti Tumor Activities of Fluoride Containing Gossypol Derivatives Compounds

Synthesis and Anti Tumor Activities of Fluoride Containing Gossypol Derivatives Compounds

... antifertility drug for a long time, and has been demonstrated to exhibit excellent anti-tumor activity towards multiple cancer types ...exhibit anti-tumor activities towards a wide range of ... See full document

8

Original Article Inflammation and cancer: inhibiting the progression of residual hepatic VX2 carcinoma by anti-inflammatory drug after incomplete radiofrequency ablation

Original Article Inflammation and cancer: inhibiting the progression of residual hepatic VX2 carcinoma by anti-inflammatory drug after incomplete radiofrequency ablation

... spread [25]. Some studies have suggested a major role for MMP-9 (92-kDa gelatinase/type IV collagenase) in the digestion of basement membrane type IV collagen, as an important mechanism for vessel invasion and metastasis ... See full document

12

Synthesis and Anti Cancer Activities of Resveratrol Derivatives

Synthesis and Anti Cancer Activities of Resveratrol Derivatives

... 6 new resveratrol derivatives were successfully ...breast cancer and gastric carcinoma cells ...of new therapeutic drugs for the clinical treat- ment of breast cancer and gastric ... See full document

7

Metformin sensitizes anticancer effect of dasatinib in head and neck squamous cell carcinoma cells through AMPK-dependent ER stress

Metformin sensitizes anticancer effect of dasatinib in head and neck squamous cell carcinoma cells through AMPK-dependent ER stress

... cell carcinoma closely associated with alcohol, betel nut, cigarette, and human papilloma virus (HPV) infection ...oral cancer is higher than that of Western countries because of betel nut ...an ... See full document

11

Original Article Reduction behavior induced by HL010183, a metformin derivative against the growth of cutaneous squamous cell carcinoma

Original Article Reduction behavior induced by HL010183, a metformin derivative against the growth of cutaneous squamous cell carcinoma

... Abstract: Metformin is a biguanide widely prescribed as a first-line antidiabetic drug in type 2 diabetes mellitus pa- ...that metformin has a strong anti-proliferative effect on various ... See full document

11

Anticancer Effect of Metformin, an anti diabetic drug, on breast Cancer Cells

Anticancer Effect of Metformin, an anti diabetic drug, on breast Cancer Cells

... and cancer are prevalent diseases whose incidence is increasing globally, in 2008 there were an estimated ...million new cancer cases ...of cancer deaths are breast, stomach, and liver ...and ... See full document

6

New Insight into the Mechanisms of the Anti-hyperglycemic Action of Metformin

New Insight into the Mechanisms of the Anti-hyperglycemic Action of Metformin

... with metformin treatment, several metabolic pathways (including those for sphingolipid and fatty acid metabolism) were significantly upregulated in the gut microbiota during metformin treatment ... See full document

9

Cushing Syndrome Revealing an Adrenocortical Carcinoma

Cushing Syndrome Revealing an Adrenocortical Carcinoma

... [1] Ghazizadeh, F., Ebadi, M., Alavi, S., Arzanian, M., Shamsian, B. and Jadali, F. (2013) Adrenocortical Carcinoma Presenting with Heterosexual Pseudoprecocious Puberty Shortly after Birth: Case Report and ... See full document

7

Nomograms to predict overall survival and cancer-specific survival in patients with adrenocortical carcinoma

Nomograms to predict overall survival and cancer-specific survival in patients with adrenocortical carcinoma

... The characteristics analyzed were marital status, sex, age at diagnosis, year at diagnosis, laterality, histologic grade, eth- nicity, primary tumor size, historic stage, treatment modality (surgery, chemotherapy, ... See full document

11

Delayed Diagnosis and False Relapse Due to Paternal Testosterone Use in Adrenocortical Carcinoma

Delayed Diagnosis and False Relapse Due to Paternal Testosterone Use in Adrenocortical Carcinoma

... emphasizing the need for prompt di- agnosis. Historically, surgery has been the mainstay of treatment. Now, clinical trials are investigating the role of in- tensive, multiagent chemotherapy, in- cluding mitotane, in ... See full document

7

Analysis of HAX-1 gene expression in esophageal squamous cell carcinoma

Analysis of HAX-1 gene expression in esophageal squamous cell carcinoma

... 112 ESCC samples and 112 non-neoplastic samples were fixed with 10% neutral buffered formalin, embedded in paraffin, and then sectioned. UltraSensitive ™ SP kit (Maxim-Bio, China) was employed for immunochemical staining ... See full document

5

Characterization of a transcriptional promoter of human papillomavirus 18 and modulation of its expression by simian virus 40 and adenovirus early antigens.

Characterization of a transcriptional promoter of human papillomavirus 18 and modulation of its expression by simian virus 40 and adenovirus early antigens.

... Cell lines used in this study Cells Human HeLa SW13 HepG2 293 Monkey CV1 COSi Origin Genital carcinoma Adrenocortical carcinoma Liver carcinoma Embryonic fibroblasts transformed with ade[r] ... See full document

9

A new era of cancer treatment: carbon nanotubes as drug delivery tools

A new era of cancer treatment: carbon nanotubes as drug delivery tools

... of drug loaded onto CNTs increases at higher temperatures, and that when the temperature exceeded 70 ° C, the concentration of anticancer drug inside the CNT increased dramatically (Figure ...the ... See full document

17

Current management options for recurrent adrenocortical carcinoma

Current management options for recurrent adrenocortical carcinoma

... Abstract: Adrenal cortical carcinoma (ACC) is a rare cancer that poses a number of manage- ment challenges due to the limited number of effective systemic treatments. Complete surgical resection offers the ... See full document

9

Retrospective Study on Diabetes Patients in two different regions in Oman

Retrospective Study on Diabetes Patients in two different regions in Oman

... diabetes. Metformin is the most prescribed drug followed by gliclazide as monotherapy, because is the most effective drug in controlling blood ... See full document

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