[PDF] Top 20 Metformin: A possible drug for treatment of endometrial cancer

... first-line drug for treat- ment of type 2 diabetes ...of metformin can reduce carcinogenic risk and inhibit proliferation of cancer cells including those from glioma and breast ...by ... See full document

... Endometrial cancer is one of the most common gynaecological cancers in the ...of endometrial cancer are rising, in part because of rising obesity ...rates. Endometrial hyperplasia is a ... See full document

... several cancer cell and mouse tumor models. In cell culture, metformin inhibits the proliferation of a range of cancer cells including breast, prostate, colon, endometrial, ovarian, and glioma ... See full document

... for metformin in anti-cancer ...of metformin including mTOR inhibition, cytotoxic effects, and ...decreased cancer incidence and mortality in patients taking ...of metformin as an ... See full document

... To identify autophagic cells, the volume of the cellular acidic compartment was visualized by AO staining [26]. Cells were seeded in 60-mm culture dishes and treated as described above. After 48 h of treatment ... See full document

... certain cancer cells. However, the behavior and the roles of LSR in endometrial cancer remain ...and endometrial cancer cells in vivo and in ...and endometrial cancer, LSR ... See full document

... of cancer; however, the main methods used in cancer treatment include surgery, radiotherapy, chemotherapy, hormone therapy (eg, androgen derivatives; ADT) and gene ...of cancer; also, ... See full document

... comparing carboplatin plus paclitaxel (six cycles) against carboplatin plus paclitaxel with bevacizu- mab every 3 weeks for 6 cycles, followed by 12 cycles of maintenance bevacizumab. The dose of bevacizumab (7.5 mg/kg) ... See full document

... fertility-preserving treatment is feasible and ...After treatment completion, women who wish to conceive are encouraged to attempt to do so as soon as ...fertility-preserving treatment, repeated ... See full document

... of metformin in preclinical models is obtained by using higher doses than those reached in diabetic patients [49], thus apparently limiting its potential use in cancer ...tissues, metformin can ... See full document

... that endometrial malignancy results from the cancerous transformation of the epithelial cells that line the inner surface of uterus ...in endometrial hyperplasia and EC [110], endometrial stromal ... See full document

... prostate cancer, endpoints for which sample sizes were smaller (Table 3 and data not ...prostate cancer risk was suggested for each current indication for use, arrhythmia ...prostate cancer for ... See full document

... Aggressive endometrial cancer cells express abnormally high levels of USP14 in situ suggesting a higher requirement for proteasome-associated DUB ...in endometrial cancer ...VLX1570 ... See full document

... the possible effects of tumor-stromal interactions on local estro- gen biosynthesis in endometrial ...from endometrial cancer patients to examine local biosynthesis of estrogens and ... See full document

... is possible that the administration of NSAIDs in combination with MEL may elicit additive effects against ...Combined treatment slightly improved the effect of single celecoxib as latency period ... See full document

... that metformin might have activity against several types of neoplastic diseases including breast ...of metformin. The effect of metformin treatment on the growth of multi-drug resistant ... See full document

... of Metformin in in vitro studies was observed in concentrations that are usually seen in diabetic patients treated with Metformin (approximately ...in drug response and the role of ... See full document

... Veljovich et al. performed a similar study and com- pared 118 patients after robotic operations with 131 women undergoing an open abdominal surgery and could demonstrate longer operative times for robotic surgery but ... See full document

... reduced cancer burden in diabetic patients treated with metformin as compared with other diabetic ...of metformin in oncology is appealing because the drug is inexpensive, relatively safe, ... See full document

... of endometrial hyperplasia treatment, whether or not PCOS is a co-morbidity, is to control abnormal vaginal bleed- ing while minimising risk of progression to endometrial carci- ...Historically, ... See full document