• No results found

[PDF] Top 20 Methotrexate resistance in relation to treatment outcome in childhood acute lymphoblastic leukemia

Has 10000 "Methotrexate resistance in relation to treatment outcome in childhood acute lymphoblastic leukemia" found on our website. Below are the top 20 most common "Methotrexate resistance in relation to treatment outcome in childhood acute lymphoblastic leukemia".

Methotrexate resistance in relation to treatment outcome in childhood acute lymphoblastic leukemia

Methotrexate resistance in relation to treatment outcome in childhood acute lymphoblastic leukemia

... AML1 was accompanied by increased MTX resistance as reflected by the TSIA. Precursor B cell ALL carrying either TEL-AML1 or E2A-PBX1 gene fusions was previously shown to accumulate decreased levels of MTX ... See full document

13

Obesity in patients with acute lymphoblastic leukemia in childhood

Obesity in patients with acute lymphoblastic leukemia in childhood

... insulin resistance, elevated plasma glu- cose, dyslipidemia, hypertension and a prothrombotic and proinflammatory ...post-cancer treatment survivors were classified as tier III, which means with an ... See full document

11

Prediction of outcomes by early treatment responses in childhood T-cell acute lymphoblastic leukemia: a retrospective study in China

Prediction of outcomes by early treatment responses in childhood T-cell acute lymphoblastic leukemia: a retrospective study in China

... of treatment outcome in childhood ALL [7 – ...to treatment outcome by the Berlin-Frankfurt-Munster (BFM) study in 1983 [7] and since then the predictive value of PR was confirmed in ... See full document

11

Evaluation of Relationship between Minimal Residual Disease (MRD) and Relapse in Childhood Acute Lymphoblastic Leukemia (ALL) Using Quantitative Fluorescent PCR

Evaluation of Relationship between Minimal Residual Disease (MRD) and Relapse in Childhood Acute Lymphoblastic Leukemia (ALL) Using Quantitative Fluorescent PCR

... Acute leukemia is the most common malignancy in children accounting for approximately one-third of all childhood ...Modern treatment protocols lead to complete remission (CR) in a considerable ... See full document

5

WILMS' TUMOR GENE 1 (WT1) EXPRESSION IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA

WILMS' TUMOR GENE 1 (WT1) EXPRESSION IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA

... the treatment outcome is excellent, with70–80% of patients achieving long-term remission, molecular aberrations that could act as new prognostic factors, MRD markers and therapeutic targets are investigated ... See full document

5

The role of ATP-binding cassette transporter A2 in childhood acute lymphoblastic leukemia multidrug resistance

The role of ATP-binding cassette transporter A2 in childhood acute lymphoblastic leukemia multidrug resistance

... MDR1 is one of the drug resistance genes that produces P-glycoprotein (p-gp). This gene is expressed in some cancers. However, in ALL, there is a controversy regarding the relationship between p- gp and MDR (7, ... See full document

9

Neurocognitive Side Effects of High Dose Methotrexate and Cranial Radiotherapy in Acute Lymphoblastic Leukemia Patients on Bfm 86 Protocol Treatment.

Neurocognitive Side Effects of High Dose Methotrexate and Cranial Radiotherapy in Acute Lymphoblastic Leukemia Patients on Bfm 86 Protocol Treatment.

... of treatment for childhood ALL in a group of patients who received dexamethasone during the intensification and maintenance phases of therapy with those in a historical control group for whom antileukemia ... See full document

78

Stroma supported culture in childhood B lineage acute lymphoblastic leukemia cells predicts treatment outcome

Stroma supported culture in childhood B lineage acute lymphoblastic leukemia cells predicts treatment outcome

... multidrug resistance, and, ultimately, treatment ...its relation with treatment ...of childhood B-lineage ALL treated in a single program of inten- sive ... See full document

7

Influence of Socioeconomic Status on Childhood Acute Lymphoblastic Leukemia Treatment in Indonesia

Influence of Socioeconomic Status on Childhood Acute Lymphoblastic Leukemia Treatment in Indonesia

... of treatment; (2) it is crucial to provide complete paren- tal education at diagnosis about leukemia, the necessity to complete treatment, and the availability of funds to prosperous, as well as ... See full document

9

Original Article CCND1 G870A polymorphism is associated with toxicity of methotrexate in childhood acute lymphoblastic leukemia

Original Article CCND1 G870A polymorphism is associated with toxicity of methotrexate in childhood acute lymphoblastic leukemia

... In 1995, Betticher and colleagues identified a single nucleotide polymorphism (G870A) in exon 4 of cyclin D1 gene (CCND1), which increases alternative splicing. The variant nucleotide interferes with splicing from exon 4 ... See full document

7

Childhood B-acute lymphoblastic leukemia: a genetic update

Childhood B-acute lymphoblastic leukemia: a genetic update

... The role of IKZF1 in BCR-ABL1 and BCR-ABL1-like ALL “BCR-ABL1-like” B-ALL, seen in 15% of childhood B- ALL, has recently been defined by gene expression pro- filing (GEP). BCR-ABL1-like B-ALL shows a similar GEP ... See full document

14

A Bayesian multivariate latent t-regression model for assessing the association between corticosteroid and cranial radiation exposures and cardiometabolic complications in survivors of childhood acute lymphoblastic leukemia: a PETALE study

A Bayesian multivariate latent t-regression model for assessing the association between corticosteroid and cranial radiation exposures and cardiometabolic complications in survivors of childhood acute lymphoblastic leukemia: a PETALE study

... Chronic low-grade inflammation is believed to be a major contributing factor for insulin resistance develop- ment [36]. ALL and its intensive treatments constitute a fertile ground for the generation of oxidative ... See full document

11

MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy

MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy

... Abstract: Methotrexate (MTX) is an important component in the therapy used to treat childhood acute lymphoblastic leukemia ...and/or outcome in pediatric ...and/or outcome ... See full document

10

Current Indications of Bone Marrow Transplantation (BMT) in Pediatric Malignant Conditions a Review

Current Indications of Bone Marrow Transplantation (BMT) in Pediatric Malignant Conditions a Review

... intensive induction chemotherapy is another poor prognostic factor. Some of these patients may never enter into CR1 and they do not benefit from HSCT while still having active leukemia. Even if remission is ... See full document

5

Case Report B-acute lymphoblastic leukemia occurring in two pediatric patients with a history of prior Wilms tumors

Case Report B-acute lymphoblastic leukemia occurring in two pediatric patients with a history of prior Wilms tumors

... marrow smear analysis revealed an abnormal increase in the amount of lymphoblast and Immature lymphocytes (60% and 88.5%, respectively) (Figure 3A), which indicated ALL (L2). Flow cytometry showed abnormal B cells ... See full document

10

PHARMACEUTICAL SCIENCE BRINGS GENETICS AND IMMUNOLOGY TOGETHER TO EVOLVE A NEW DIMENSION IN TREATING CHILDHOOD CANCER: A REVIEW

PHARMACEUTICAL SCIENCE BRINGS GENETICS AND IMMUNOLOGY TOGETHER TO EVOLVE A NEW DIMENSION IN TREATING CHILDHOOD CANCER: A REVIEW

... Yet another high rate if incidence is encountered at old age also 3 . The most common symptom of this disease is a reduced production of functional blood cells since leukemia utilizes bone marrow resources that ... See full document

6

Genetic Aberrations In Childhood Acute Lymphoblastic Leukaemia (All): Application Of High-Density Single Nucleotide Polymorphism Array (SNPA)

Genetic Aberrations In Childhood Acute Lymphoblastic Leukaemia (All): Application Of High-Density Single Nucleotide Polymorphism Array (SNPA)

... on childhood ALL by Kuiper et ...of childhood ALL ...in childhood ALL, which indicates the power of SNPA analysis in the study of cancer ...in childhood ALL ...in childhood ALL, which ... See full document

8

Protein kinase inhibitors for acute leukemia

Protein kinase inhibitors for acute leukemia

... Acute leukemia is subdivided into acute myelocytic leukemia (AML) and acute lymphoblastic leukemia (ALL) [1, ...all acute leukemias in adults, and the cure rates ... See full document

7

Expression of the polycomb group gene Bmi1 does not affect the prognosis of pediatric acute lymphoblastic leukemia

Expression of the polycomb group gene Bmi1 does not affect the prognosis of pediatric acute lymphoblastic leukemia

... In acute lymphoblastic leukemia, it was reported that CD90+/CD110+ cells in acute lymphoblastic T-cell leu- kemia, and CD9-overexpressing cells in acute lym- phoblastic B-cell ... See full document

6

Obesity in Pediatric ALL Survivors: A Meta-Analysis

Obesity in Pediatric ALL Survivors: A Meta-Analysis

... We searched MEDLINE from inception through January 29, 2013, to identify studies that investigated obesity in ALL patients or survivors. We used medical subject heading and text words related to obesity ( “ obesity, ” “ ... See full document

14

Show all 10000 documents...