[PDF] Top 20 MicroRNA-137 is downregulated in glioblastoma and inhibits the stemness of glioma stem cells by targeting RTVP-1
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MicroRNA-137 is downregulated in glioblastoma and inhibits the stemness of glioma stem cells by targeting RTVP-1
... After 1 week the transduction efficacy in the neurospheres was determined using real-time PCR analysis (D) and fluorescence microscopy ...the stemness markers, Nanog, Sox2, Oct4 and Shh was determined in ... See full document
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MicroRNA-137 reduces stemness features of pancreatic cancer cells by targeting KLF12
... PANC-1 cells was examined by flow cytometry and ...cancer cells in ...promote stemness maintenance, local tumor invasion, and distant ...PANC-1 cells treated with miR-137 ... See full document
16
miR128-1 inhibits the growth of glioblastoma multiforme and glioma stem-like cells via targeting BMI1 and E2F3
... is downregulated in glioblastoma multiforme (GBM) and closely associated with the progression of ...was downregulated in GBM and glioma stem-like cells ...GBM cells and ... See full document
14
MicroRNA-153/Nrf-2/GPx1 pathway regulates radiosensitivity and stemness of glioma stem cells via reactive oxygen species
... in glioma compared with normal brain tissues and decreases cell proliferation and increases apoptosis by targeting B cell lymphoma 2 (Bcl-2) and myeloid cell leukemia sequence 1 (Mcl-1) genes ... See full document
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Repurposing phenformin for the targeting of glioma stem cells and the treatment of glioblastoma
... of glioma stem cells (GSCs) using both in vitro and in vivo ...of stemness and mesenchymal markers and increased the expression of miR-124, 137 and ... See full document
15
<p>Propofol Inhibits the Migration and Invasion of Glioma Cells by Blocking the PI3K/AKT Pathway Through miR-206/ROCK1 Axis</p>
... in glioma progression, the potential targets of miR-206 were predicted according to the ...LN229 cells (Figure 4B and ...LN229 cells (Figure 4C and ...miR-206-transfected cells (Figure ... See full document
10
RNA nanoparticle as a vector for targeted siRNA delivery into glioblastoma mouse model
... in glioblastoma targeting is folate, a natural member of the B-vitamin ...proliferating cells, many cancer cells, such as those of the brain, ovary, lung, breast, kidney, endometrium, colon ... See full document
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MicroRNA reexpression as differentiation therapy in cancer
... The two major histological types of RMS tumors are alveolar RMS, the more aggres- sive subtype defined by specific translo- cations involving the genes paired box 3 (PAX3) or paired box 7 (PAX7) and forkhead box O1 (FKHR ... See full document
6
miR-1 inhibits the proliferation of breast cancer stem cells by targeting EVI-1
... by flow cytometry. Real-time PCR and Western blotting were used to determine the expres- sion of miRNAs, mRNAs, and epithelial–mesenchymal transition (EMT)-related genes. Cell proliferation and apoptosis were measured ... See full document
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<p>Gold quantum dots impair the tumorigenic potential of glioma stem-like cells via β-catenin downregulation in vitro</p>
... U373 glioblastoma cells, SNU-80 (thyroid cancer), H460 (lung cancer), MRC5 (normal lung fibroblast), and HEK293 (normal embryonic kidney cells) were established from the American Type Culture ... See full document
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<p>miRNAs: A Promising Target in the Chemoresistance of Bladder Cancer</p>
... Abstract: Chemotherapy is an important cancer treatment method. Tumor chemotherapy resistance is one of the main factors leading to tumor progression. Like other malignancies, bladder cancer, especially muscle-invasive ... See full document
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CCAAT/enhancer-binding protein delta regulates the stemness of glioma stem-like cells through activating PDGFA expression upon inflammatory stimulation
... CCAAT/enhancer-binding protein delta belongs to the CCAAT/enhancer-binding protein (C/EBP) family. The expression of CEBPD protein is regulated by a va- riety of extracellular stimuli, such as IL-1β and tumor necrosis ... See full document
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MicroRNA-7 inhibits the stemness of prostate cancer stem-like cells and tumorigenesis by repressing KLF4/PI3K/Akt/p21 pathway
... PCSCs’ stemness by miR-7 restoration is achieved via inhibition of its target KLF4, we established PC3-shKLF4 vs PC3-con subclone cell lines to investigate whether phenotypes observed after KLF4 knock-down was ... See full document
15
Regression/Eradication of gliomas in mice by a systemically- deliverable ATF5 dominant-negative peptide
... of 1 mg/kg at intervals of 1-2 ...tumor cells, and for TUNEL to identify dying ...brain cells (in the contralateral hemisphere from the tumor) showed Flag staining indicative of extensive ... See full document
13
Motility of glioblastoma cells is driven by netrin-1 induced gain of stemness
... of glioma patients has not been ...primary glioma sam- ples [34, ...the stemness of GBM cells and to poor prognosis of glioma pa- tients [37, ...Both glioma-specific and ... See full document
18
Original Article miR-107 promotes hepatocellular carcinoma cell proliferation by targeting Axin2
... Axin2 is a negative regulator of the canonical Wnt/β-catenin signaling pathway, and func- tions as a tumor suppressor in a number of human cancers [20]. Koinuma et al showed that epigenetic silencing of Axin2 is ... See full document
7
Mesenchymal stem cells deliver synthetic microRNA mimics to glioma cells and glioma stem cells and inhibit their cell migration and self-renewal
... of stem cells which exhibits tropism to tumor cells are the adult human mesenchymal stromal stem cells ...These cells can be obtained from autologous bone marrow and adipose ... See full document
16
NADH autofluorescence, a new metabolic biomarker for cancer stem cells : identification of Vitamin C and CAPE as natural products targeting “stemness”
... cancer stem-like cells (CSCs). First, we subjected MCF7 cells to “metabolic fractionation” by flow cytometry, using fluorescent mitochondrial probes to detect PCG1 α activity, as well ROS and ... See full document
13
Targeting of glioblastoma cell lines and glioma stem cells by combined PIM kinase and PI3K-p110 inhibition
... to glioblastoma cell lines, combined treatment with SGI- 1776 and BYL-719 exerted synergistic antineoplastic effects on cell viability (CI = ...for targeting both GBM tumor cells including their GSC ... See full document
10
MicroRNA-346 inhibits the growth of glioma by directly targeting NFIB
... Briefly, cells or tissues were lysed on ice for 30 min in radioimmunoprecipita- tion assay buffer [150 mM NaCl, 100 mM Tris, pH ...(SDS), 1% Triton X-100, 1% sodium deoxycholate, 5 mM EDTA, and 10 mM ... See full document
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